PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PGC	4	CCNT1	3	affinity chromatography technology	Hanyu-Nakamura K (2008)	1
CCNT1	3	CDK9	3	pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, genetic interference, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, biochemical, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cabart P (2004), Young TM (2003), Michels AA (2003), Michels AA (2003), Michels AA (2003), Hoque M (2003), Kiernan RE (2001), De Falco G (2000), Fu TJ (1999), Fu TJ (1999), Peng J (1998), Peng J (1998), Peng J (1998), Garber ME (2000), Garber ME (2000), Garber ME (2000), He N (2006), Jeronimo C (2007), Bres V (2009), Gargano B (2007), Yokoyama A (2010), Fryer CJ (2004), Yik JH (2003), Mak AB (2010), Mak AB (2010), Liu M (2012), Shan B (2005), Baumli S (2008), Baumli S (2008), Havugimana PC (2012), Herrmann CH (2001), Herrmann CH (2001), Herrmann CH (2001), Napolitano G (2003), Chen R (2004), Chen R (2004), Chen R (2004), Larochelle S (2012), Yik JH (2005), Napolitano G (1999), Garriga J (1998), Napolitano G (2002), Nguyen VT (2001), Takahashi H (2011), Yang Z (2005), Yang Z (2001), Yang Z (2001), Pinhero R (2004), Byers SA (2005), Wei P (1998), Wei P (1998), Wei P (1998), Wei P (1998), Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Lin PH (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	64
CCNT1	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Wittmann BM (2005), Wittmann BM (2005), Wittmann BM (2005), Wittmann BM (2005)	4
ATP4A	6	PGC	4	affinity chromatography technology	Lapierre LA (2007)	1
PGC	4	CDK9	3	affinity chromatography technology	Hanyu-Nakamura K (2008)	1
PGC	4	ESR1	0	pull down	Bourdoncle A (2005)	1