PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIRA	5	PFKFB3	2	affinity chromatography technology	Lee JS (2016)	1
HIF1A	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chew EH (2007), Sufan RI (2006), Luo W (2010), Heir P (2013), Russell RC (2008)	5
CYLD	2	ELAVL1	0	affinity chromatography technology	Elliott PR (2016)	1
MAGOH	0	PFKFB3	2	affinity chromatography technology	Singh G (2012)	1
GCK	2	PFKFB2	4	two hybrid	Baltrusch S (2001)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CYLD	2	PFKFB3	2	affinity chromatography technology	Elliott PR (2016)	1
ARNT	1	CUL2	3	affinity chromatography technology	Sufan RI (2009)	1
HIST1H3E	0	PFKFB3	2	affinity chromatography technology	Campos EI (2015)	1
ELAVL1	0	PFKFB3	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CYLD	2	PFKFB2	4	affinity chromatography technology	Elliott PR (2016)	1
TRIM25	5	PFKFB2	4	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	HIRA	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ELAVL1	0	ARNT	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HIF1A	1	PFKFB4	0	imaging technique	Kumar P (2015)	1
GCK	2	PFKFB3	2	protein complementation assay	Cullen KS (2011)	1
ARRB1	2	PFKFB3	2	affinity chromatography technology	Xiao K (2007)	1
ARNT	1	PFKFB3	2	imaging technique	Kumar P (2015)	1
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PES1	3	PFKFB3	2	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	PFKFB2	4	affinity chromatography technology	Campos EI (2015)	1
PFKFB3	2	PFKFB2	4	affinity chromatography technology	Huttlin EL (2017)	1
PFKFB3	2	PFKFB4	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	HIRA	5	affinity chromatography technology	Choudhury NR (2017)	1
ARNT	1	PFKFB4	0	imaging technique	Kumar P (2015)	1
ELAVL1	0	HIF1A	1	affinity chromatography technology, unspecified method	Galban S (2008), Galban S (2008)	2
ARRB1	2	PES1	3	affinity chromatography technology	Ewing RM (2007)	1
HIF1A	1	PFKFB3	2	imaging technique	Kumar P (2015)	1
HIF1A	1	CBFA2T3	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kumar P (2015), Kumar P (2015), Kumar P (2015), Kumar P (2015)	4
ARNT	1	HIF1A	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid	Woods SL (2002), Hogenesch JB (1997), Hogenesch JB (1997), Behrends C (2010), Wang F (2004), Lim W (2011), Sufan RI (2009), Sufan RI (2009), Katschinski DM (2004), Katschinski DM (2004), Chun YS (2002), Hein MY (2015), Huttlin EL (2017), Kalousi A (2010), Kalousi A (2010), Isaacs JS (2004), Chilov D (1999), Chilov D (1999), Chilov D (1999), Kallio PJ (1997), Amir S (2009), Yang L (2008), Hur E (2002), Lando D (2000), Sadek CM (2000), Chapman-Smith A (2006), Suzuki H (2001), Suzuki H (2001), Li YM (2005), Jiang BH (1996), Jiang BH (1996), Jiang BH (1996), Jiang BH (1996), Park EJ (2006), Park EJ (2006), Ruas JL (2005), Wotzlaw C (2007), Ivanov AA (2017), Depping R (2004), Depping R (2004), Depping R (2004)	41
ARRB2	5	PES1	3	affinity chromatography technology	Ewing RM (2007)	1
ARRB2	5	PFKFB3	2	affinity chromatography technology	Xiao K (2007)	1
CUL2	3	PFKFB3	2	affinity chromatography technology	Ewing RM (2007)	1
TRIM25	5	PFKFB3	2	affinity chromatography technology	Choudhury NR (2017)	1
CUL2	3	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
HIF1A	1	ARRB1	2	affinity chromatography technology	Shenoy SK (2012)	1
ASB12	0	PFKFB3	2	affinity chromatography technology	Andresen CA (2014)	1
CBFA2T3	3	PFKFB3	2	imaging technique	Kumar P (2015)	1
CBFA2T3	3	PFKFB4	0	imaging technique	Kumar P (2015)	1
PFKFB3	2	CLUH	8	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	PFKFB3	2	affinity chromatography technology	Tong J (2014)	1
EIF4A3	1	PFKFB3	2	affinity chromatography technology	Singh G (2012)	1
MAGOH	0	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Singh G (2012), Singh G (2012), Barbosa I (2012)	7