PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VCAN	9	CXCL12	0	pull down	Hirose J (2001)	1
PF4	0	PROC	1	pull down	Dudek AZ (1997)	1
PF4	0	CXCL12	0	pull down	Salcedo R (1999)	1
PF4	0	THBD	0	pull down	Dudek AZ (1997)	1
CXCR3	0	PF4	0	pull down	Lasagni L (2003)	1
VCAN	9	PF4	0	pull down	Hirose J (2001)	1
PF4	0	LDLR	4	pull down	Sachais BS (2002)	1
PF4	0	PF4	0	x-ray crystallography, x-ray crystallography, pull down	Zhang X (1994), Mayo KH (1995), Barker S (1995)	3