PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC27	2	CDC26	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Gmachl M (2000), Kraft C (2003), Dube P (2005), Holzmann J (2011), Gmachl M (2000), Vodermaier HC (2003), Vodermaier HC (2003), Masuda K (2015)	8
CDC23	3	ANAPC16	0	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
ANAPC4	0	ANAPC5	2	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	8
ANAPC1	1	ANAPC5	2	biochemical, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015)	4
CDC27	2	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Hein MY (2015), Qiao R (2016), Qiao R (2016), Boldt K (2016)	18
CDC27	2	ANAPC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Koloteva-Levine N (2004), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Havugimana PC (2012), Song MS (2011), Vodermaier HC (2003), Tran K (2010), Kelly A (2014), Craney A (2016), Qiao R (2016)	15
PENK	1	ANAPC5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANAPC5	2	ANAPC16	0	biochemical	Wan C (2015)	1
ANAPC4	0	CDC26	0	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Masuda K (2015)	6
PENK	1	CDC23	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC27	2	ANAPC1	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Sumara I (2000), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Holzmann J (2011), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Qiao R (2016), Qiao R (2016)	12
ANAPC1	1	ANAPC16	0	biochemical	Wan C (2015)	1
ANAPC1	1	CDC26	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ANAPC1	1	CDC23	3	biochemical, biochemical, affinity chromatography technology	Sumara I (2000), Havugimana PC (2012), Hein MY (2015)	3
CDC23	3	CDC26	0	affinity chromatography technology	Hein MY (2015)	1
PENK	1	ANAPC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PENK	1	PDYN	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC27	2	ANAPC16	0	affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical	Lara-Gonzalez P (2011), Holzmann J (2011), Yamaguchi M (2015), Yamaguchi M (2015), Yamaguchi M (2015), Wan C (2015)	6
PENK	1	CDC26	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANAPC4	0	CDC23	3	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015)	8
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
ANAPC1	1	ANAPC4	0	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	9
PENK	1	CDC27	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANAPC16	0	CDC26	0	biochemical	Wan C (2015)	1
ANAPC5	2	CDC23	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
PENK	1	ANAPC4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANAPC4	0	ANAPC16	0	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical	Zhang Z (2012), Chang L (2014), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	5
PENK	1	ANAPC16	0	affinity chromatography technology	Huttlin EL (2015)	1