PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PEG3	2	SIAH2	0	affinity chromatography technology, two hybrid	Relaix F (2000), Relaix F (2000)	2
TRAF2	1	SIAH2	0	pull down	Habelhah H (2002)	1
PEG3	2	PEG3	2	x-ray crystallography	Rimsa V (2013)	1
PEG3	2	SIAH1	2	affinity chromatography technology, two hybrid	Relaix F (2000), Relaix F (2000)	2
BRCA1	7	PEG3	2	far western blotting	Yarden RI (2001)	1
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
TRAF2	1	PEG3	2	affinity chromatography technology, two hybrid	Relaix F (1998), Relaix F (1998)	2
ALB	1	PEG3	2	affinity chromatography technology	Zhou M (2004)	1
USP7	14	PEG3	2	two hybrid	Lim J (2006)	1
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5