PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL5	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	3
CUL5	1	TUBB4A	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
HIF1AN	0	TUBB4A	3	affinity chromatography technology	Rodriguez J (2016)	1
ASB7	1	RNF7	0	affinity chromatography technology, affinity chromatography technology	Kohroki J (2005), Andresen CA (2014)	2
ASB4	2	TUBB2A	2	affinity chromatography technology	Andresen CA (2014)	1
ASB4	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferguson JE (2007), Andresen CA (2014), Andresen CA (2014)	3
UBE2D1	0	RNF7	0	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Yasukawa T (2008), Zakaria R (2013), Kuang Z (2010), Lamsoul I (2011), Heuze ML (2008), Kershaw NJ (2014), Uematsu K (2016), Lo JY (2017)	9
ASB4	2	GPS1	1	affinity chromatography technology, affinity chromatography technology	Li JY (2007), Li JY (2007)	2
CUL5	1	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
ASB4	2	DNAJB5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2015), Huttlin EL (2017)	3
HIF1AN	0	ELOB	1	affinity chromatography technology	Rodriguez J (2016)	1
ID2	0	ASB4	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Townley-Tilson WH (2014), Townley-Tilson WH (2014), Townley-Tilson WH (2014)	3
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
ASB4	2	HSPB1	2	affinity chromatography technology	Andresen CA (2014)	1
ASB4	2	RIT1	1	affinity chromatography technology	Ferguson JE (2007)	1
HSPB1	2	STUB1	4	two hybrid	Katsogiannou M (2014)	1
CUL2	3	TUBB2A	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	GPS1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001)	2
CUL5	1	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	UBE2D1	0	pull down, affinity chromatography technology, pull down	Sufan RI (2006), Sufan RI (2006), Maine GN (2007)	3
HSP90AA1	7	ASB4	2	affinity chromatography technology	Taipale M (2012)	1
CUL2	3	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
ASB4	2	FARSA	6	affinity chromatography technology	Andresen CA (2014)	1
HSPB8	0	HSPB1	2	two hybrid, affinity chromatography technology	Sun X (2004), Irobi J (2004)	2
ASB4	2	HSPD1	0	affinity chromatography technology	Andresen CA (2014)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
ASB4	2	TUBB4A	3	affinity chromatography technology	Andresen CA (2014)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
HSPB1	2	HSP90AA1	7	two hybrid	Katsogiannou M (2014)	1
DDB1	6	GPS1	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Jin J (2006), Emberley ED (2012), Cavadini S (2016)	3
ASB4	2	HSPB8	0	affinity chromatography technology	Andresen CA (2014)	1
ASB4	2	STUB1	4	affinity chromatography technology	Andresen CA (2014)	1
ASB4	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Andresen CA (2014)	2
CUL4A	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Bennett EJ (2010), Taipale M (2012)	3
CUL2	3	ELOB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kamura T (2001), Menon S (2008), Megumi Y (2005), Kamura T (2002), Brower CS (2002), Bennett EJ (2010), Pause A (1997), Kamura T (2004), Kelsall IR (2013)	9
TUBB2A	2	TUBB3	3	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
ASB7	1	ASB4	2	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Andresen CA (2014)	2
ASB4	2	ELOB	1	affinity chromatography technology	Ferguson JE (2007)	1
ASB7	1	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2017)	2
ASB4	2	RPS27L	0	affinity chromatography technology	Andresen CA (2014)	1
ASB4	2	DDB1	6	affinity chromatography technology	Andresen CA (2014)	1
ASB4	2	TUBB8	2	affinity chromatography technology	Andresen CA (2014)	1
RNF7	0	ELOB	1	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
CUL2	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
TUBB8	2	TUBB2A	2	biochemical	Kristensen AR (2012)	1
ASB4	2	TUBB3	3	affinity chromatography technology	Andresen CA (2014)	1
STUB1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Xu Z (2008), Xia T (2007), Jiang J (2001), Graf C (2010), Soss SE (2011), Pabarcus MK (2009), Wang Y (2011), Summers DW (2009), Clapp KM (2010), Wang L (2011), Ren HY (2011), Urushitani M (2004), Plechanovova A (2012), Al-Ramahi I (2006), Germano S (2006), Alberti S (2004), Peng HM (2004), Qian SB (2009), Yang M (2011), Lee H (2006), Windheim M (2008), Tsukahara F (2010), Zhou P (2003), Chymkowitch P (2011), Shimamoto S (2013), Spooner RA (2008), Zhang M (2005), Uchiki T (2009), Wang Y (2011), Wang Y (2015), Narayan V (2015), Clapp KM (2012), Kim HT (2007), McClurg UL (2016), Blessing NA (2017), Landre V (2017), Kopp Y (2017)	37
RNF7	0	CUL4A	2	two hybrid, enzymatic study	Ohta T (1999), Huang DT (2009)	2
ASB4	2	CUL2	3	affinity chromatography technology	Ferguson JE (2007)	1
ASB4	2	HIF1AN	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ferguson JE (2007), Ferguson JE (2007), Huttlin EL (2015), Huttlin EL (2017)	4
GPS1	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stotland A (2012), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Scherer PC (2016)	5
ASB4	2	TFRC	1	affinity chromatography technology	Andresen CA (2014)	1
HIF1AN	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
DNAJB4	0	DNAJB5	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASB7	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohroki J (2005), Bennett EJ (2010), Andresen CA (2014), Uematsu K (2016), Huttlin EL (2017)	5
RNF7	0	CUL2	3	two hybrid, enzymatic study	Ohta T (1999), Huang DT (2009)	2
ASB4	2	RNF7	0	affinity chromatography technology	Andresen CA (2014)	1
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
ASB4	2	UBE2D1	0	pull down	Townley-Tilson WH (2014)	1
ASB7	1	ELOB	1	affinity chromatography technology	Andresen CA (2014)	1
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
ASB4	2	DNAJB4	0	affinity chromatography technology	Andresen CA (2014)	1