PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D4	0	RNF43	5	two hybrid	van Wijk SJ (2009)	1
LRSAM1	2	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF14	2	PHF7	5	two hybrid	Woodsmith J (2012)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
UBE2D4	0	RCHY1	0	two hybrid	Markson G (2009)	1
MYLIP	1	UBE2D4	0	pull down	Zhang L (2011)	1
UBE2D4	0	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
UBE2D4	0	F3	0	enzymatic study	Ettelaie C (2016)	1
UBE2D4	0	TRIM35	1	two hybrid	Markson G (2009)	1
MCM2	3	CNOT4	4	affinity chromatography technology	Drissi R (2015)	1
UBE2D4	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
UBE2D4	0	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014), Yu H (2011)	5
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
MCM2	3	MAP3K1	4	affinity chromatography technology	Drissi R (2015)	1
UBE2D4	0	DTX2	3	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Rual JF (2005), Markson G (2009), Rolland T (2014)	4
TRIM38	3	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
TRIM25	5	DAZAP2	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D4	0	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM5	4	two hybrid	Markson G (2009)	1
AMFR	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
UBE2D4	0	RNF130	0	two hybrid	van Wijk SJ (2009)	1
UBE2D4	0	ZNRF4	1	two hybrid	van Wijk SJ (2009)	1
TRIM43	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
RNF166	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
UBE2D4	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
MAP3K1	4	RNF114	0	enzymatic study	Charlaftis N (2014)	1
TRIM50	1	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
UBE2D4	0	RFWD3	5	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
PHF7	5	ARIH2	4	two hybrid	Woodsmith J (2012)	1
ARIH2	4	TRIM27	2	two hybrid	Woodsmith J (2012)	1
MKRN3	2	RNF7	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
RNF13	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RLIM	1	two hybrid	Markson G (2009)	1
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
RNF38	4	DTX3	4	two hybrid	Woodsmith J (2012)	1
TRIM5	4	MAP3K1	4	affinity chromatography technology	Pertel T (2011)	1
DAZAP2	1	RNF115	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
UBA1	1	UBE2D4	0	enzymatic study, enzymatic study	Wauer T (2015), Huguenin-Dezot N (2016)	2
RNF181	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM25	5	DTX2	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
TRIM45	1	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	TRIM25	5	two hybrid	Markson G (2009)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
UBE2D4	0	ZNRF1	1	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
DTX3	4	CHFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D4	0	DTX3	4	two hybrid	Markson G (2009)	1
PHF7	5	UBE2D4	0	two hybrid	Rolland T (2014)	1
SIAH1	2	RLIM	1	affinity chromatography technology	Kraemer OH (2008)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
UBE2D4	0	RNF115	1	two hybrid, two hybrid	van Wijk SJ (2009), Rolland T (2014)	2
UBE2D4	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
MID1	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBE2D4	0	XIAP	0	two hybrid	Markson G (2009)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	TRAF7	11	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
MAP3K1	4	RBCK1	0	enzymatic study	Charlaftis N (2014)	1
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
RNF126	2	MCM2	3	affinity chromatography technology	OConnor HF (2015)	1
OTUB1	0	RNF126	2	two hybrid	Hayes SD (2012)	1
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
PHF7	5	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Colland F (2004), Yu H (2011)	4
MCM2	3	DTX2	3	affinity chromatography technology	Drissi R (2015)	1
UBE2D4	0	UHRF2	1	two hybrid	van Wijk SJ (2009)	1
TRIM27	2	UHRF2	1	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	TRIM2	1	two hybrid	Markson G (2009)	1
TRIM25	5	CHFR	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM38	3	TRAF6	0	affinity chromatography technology	Zhao W (2012)	1
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
UBE2D4	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
TRIM8	6	RNF7	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
PHF7	5	DTX3L	1	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RMND5B	0	two hybrid	van Wijk SJ (2009)	1
MAGEA11	1	UBE2D4	0	two hybrid	Rual JF (2005)	1
UBE2D4	0	SIAH1	2	two hybrid	van Wijk SJ (2009)	1
RNF2	1	RCHY1	0	affinity chromatography technology	Cao Q (2014)	1
MKRN2	2	UBE2D4	0	two hybrid	Rolland T (2014)	1
DZIP3	6	RNF38	4	two hybrid	Woodsmith J (2012)	1
ZNRF2	0	ZNRF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012)	4
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
TRIM8	6	MKRN3	2	two hybrid	Woodsmith J (2012)	1
TRIM23	3	SIAH1	2	two hybrid	Rolland T (2014)	1
TRIM3	2	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
UBE2D4	0	TRAF7	11	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF38	4	two hybrid	Markson G (2009)	1
RBCK1	0	UHRF2	1	two hybrid	Woodsmith J (2012)	1
RBCK1	0	MKRN2	2	two hybrid	Woodsmith J (2012)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
UBE2D4	0	UBOX5	4	two hybrid	Markson G (2009)	1
OTUB1	0	UBTD1	0	affinity chromatography technology	Scholz CC (2016)	1
UBE2D4	0	UBE4A	2	two hybrid	van Wijk SJ (2009)	1
UBE2D4	0	RBCK1	0	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF4	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013)	3
UBE2D4	0	DTX3L	1	two hybrid	Markson G (2009)	1
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
TRIM35	1	TRIM5	4	pull down	Li X (2006)	1
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
UBE2D4	0	TRIM17	5	two hybrid	Markson G (2009)	1
TRIM5	4	MKRN3	2	two hybrid	Woodsmith J (2012)	1
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF114	0	two hybrid	Markson G (2009)	1
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
UBE2D4	0	TRIM43	0	two hybrid	Markson G (2009)	1
TRIM25	5	RNF38	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RMND5B	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D4	0	RNF103	1	two hybrid	van Wijk SJ (2009)	1
RNF138	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	TRIM31	0	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2D4	0	RNF150	2	two hybrid	van Wijk SJ (2009)	1
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
UBE2D4	0	CADPS2	0	two hybrid	van Wijk SJ (2009)	1
TRIM23	3	RNF126	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	MKRN3	2	two hybrid	Markson G (2009)	1
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
UBE2D4	0	MARCH3	0	two hybrid	Markson G (2009)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
MAGEA11	1	TRIM27	2	two hybrid	Rual JF (2005)	1
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
DTX1	2	DTX3L	1	affinity chromatography technology	Takeyama K (2003)	1
TRIM8	6	UHRF2	1	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF2	1	two hybrid	Markson G (2009)	1
UBTD1	0	UBE2D4	0	two hybrid	Uhler JP (2013)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
UBE2D4	0	RING1	2	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF7	0	two hybrid	Markson G (2009)	1
UBE2D4	0	BIRC8	0	two hybrid	Markson G (2009)	1
RBCK1	0	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	BFAR	0	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF26	2	two hybrid	Markson G (2009)	1
MAP3K1	4	RNF126	2	enzymatic study	Charlaftis N (2014)	1
UBE2D4	0	INCA1	1	two hybrid	Rolland T (2014)	1
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF13	0	two hybrid	van Wijk SJ (2009)	1
TRIM43	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
MYBL2	2	UBE2D4	0	two hybrid	Wang J (2011)	1
CHFR	5	MCM2	3	affinity chromatography technology	Oh YM (2009)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
RNF7	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF166	0	two hybrid	Markson G (2009)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
UBE2D4	0	OTUB1	0	two hybrid	Rolland T (2014)	1
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
MCM2	3	UBE2D4	0	affinity chromatography technology	Drissi R (2015)	1
UBE2D4	0	ZNRF2	0	two hybrid	van Wijk SJ (2009)	1
TRIM2	1	TRIM3	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF138	0	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF14	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
DTX1	2	MAP3K1	4	affinity chromatography technology, pull down	Liu WH (2005), Liu WH (2005)	2
MID2	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBE2D4	0	RNF25	1	two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Huttlin EL (2017)	3
UBE2D4	0	MGRN1	4	two hybrid	Markson G (2009)	1
TRIM8	6	TRIM2	1	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	CHFR	5	two hybrid	Markson G (2009)	1
XIAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	MUL1	1	two hybrid, pull down	van Wijk SJ (2009), Ni G (2017)	2
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	CNOT4	4	two hybrid	van Wijk SJ (2009)	1
RNF125	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF126	2	two hybrid, two hybrid	Rual JF (2005), Markson G (2009)	2
UBE2D4	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
TRIM17	5	TRAF6	0	two hybrid	Woodsmith J (2012)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
UBE2D4	0	DZIP3	6	two hybrid	Markson G (2009)	1
UBE2D4	0	MID1	1	two hybrid, two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011)	3
UBE2D4	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
TRIM31	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
TRIM39	0	UBTD1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
SIAH1	2	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM10	3	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
MCM2	3	SIAH1	2	affinity chromatography technology	Drissi R (2015)	1
UBE2D4	0	RNF185	1	two hybrid	Markson G (2009)	1
UBE2D4	0	ARIH2	4	two hybrid	Markson G (2009)	1
STUB1	4	UBE2D4	0	pull down	Blessing NA (2017)	1
RCHY1	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF10	0	two hybrid	Markson G (2009)	1
TRIM10	3	TRIM35	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	UBE2D4	0	enzymatic study	David Y (2010)	1
DAZAP2	1	UBE2D4	0	two hybrid	Rolland T (2014)	1
UBE2D4	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
UBE2D4	0	RNF125	0	two hybrid	Markson G (2009)	1
TRIM23	3	UBE2D4	0	pull down	Dawidziak DM (2017)	1
UBE2D4	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2D4	0	UFM1	0	two hybrid	van Wijk SJ (2009)	1
ZNRF4	1	AMFR	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2D4	0	MIB1	5	two hybrid	van Wijk SJ (2009)	1
UBTD1	0	RNF10	0	two hybrid	Uhler JP (2013)	1
PRKN	1	UBE2D4	0	pull down	Kazlauskaite A (2014)	1