PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPUL1	1	TGM2	2	two hybrid	Wang J (2011)	1
BARD1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dong Y (2003), Dong Y (2003), Feki A (2005), Jiang J (2011), Tembe V (2015), Tembe V (2015), Tembe V (2015)	7
CALCOCO2	0	MAP1LC3A	0	affinity chromatography technology, affinity chromatography technology	Thurston TL (2009), Verlhac P (2015)	2
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
VHL	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai Y (2011), Yao P (2013), Yao P (2013)	3
SMAD1	0	SKIL	3	affinity chromatography technology	Mizuide M (2003)	1
SMAD4	9	HNF4A	2	pull down	Kardassis D (2000)	1
SMAD1	0	PIAS4	5	two hybrid, affinity chromatography technology, two hybrid	Long J (2003), Long J (2003), Colland F (2004)	3
PIAS4	5	SMAD7	1	two hybrid, affinity chromatography technology, two hybrid	Imoto S (2003), Imoto S (2003), Colland F (2004)	3
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
MAP1LC3A	0	SERBP1	2	affinity chromatography technology	Wang BS (2013)	1
IRF3	4	IRF7	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Au WC (2001), Au WC (2001), Higgs R (2008), Higgs R (2008)	4
FANCI	1	REV1	1	affinity chromatography technology	Yang Y (2015)	1
BARD1	4	LRIF1	3	two hybrid	Goehler H (2004)	1
SERBP1	2	PIAS4	5	two hybrid	Lemos TA (2006)	1
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
SUMO2	0	TP53BP1	3	pull down	Ouyang J (2009)	1
TOP2A	2	VHL	0	affinity chromatography technology	Yun J (2009)	1
ETS1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee S (2008), Lee S (2008), Kim E (2003), Zhu M (2014)	4
CHD3	19	ZHX1	1	two hybrid	Goehler H (2004)	1
CLK1	1	REV1	1	enzymatic study	Lipp JJ (2015)	1
SATB1	1	UBE2I	0	two hybrid, two hybrid, two hybrid, enzymatic study	Rual JF (2005), Tan JA (2010), Tan JA (2008), Gocke CB (2005)	4
CEBPD	0	PIAS4	5	pull down	Zhou S (2008)	1
BRCA1	7	PHGDH	4	affinity chromatography technology	Ertych N (2016)	1
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
HDAC1	4	TOP2A	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid	Tsai SC (2000), Johnson CA (2001), Johnson CA (2001), Johnson CA (2001), Johnson CA (2001)	5
ALDOA	0	PIAS4	5	two hybrid	Wang J (2011)	1
HNRNPL	3	CHD3	19	affinity chromatography technology	Fei T (2017)	1
NEFL	1	PDE4DIP	10	two hybrid	Rolland T (2014)	1
PIAS4	5	ZW10	2	affinity chromatography technology, pull down	Ryu H (2010), Ryu H (2010)	2
SUMO2	0	ZHX1	1	two hybrid	Hecker CM (2006)	1
LEF1	3	SMAD3	1	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005), Cui Q (2005), Cui Q (2005)	5
ZMIZ2	1	TP53	0	two hybrid	Lee J (2007)	1
ERBB4	5	TP53	0	affinity chromatography technology	Gilmore-Hebert M (2010)	1
SATB1	1	HDAC2	1	biochemical	Yasui D (2002)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
PHGDH	4	PIAS4	5	two hybrid	Wang J (2011)	1
ZHX1	1	PIAS4	5	two hybrid	Goehler H (2004)	1
ZNF512B	2	PIAS4	5	two hybrid	Colland F (2004)	1
PIAS2	2	HIC1	1	enzymatic study, imaging technique	Stankovic-Valentin N (2007), Sun L (2013)	2
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
UBE2I	0	MECOM	4	enzymatic study	Singh S (2013)	1
BRCA1	7	KPNB1	3	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	HDAC2	1	pull down, affinity chromatography technology, genetic interference	Yarden RI (1999), Chang S (2011), Shen JP (2017)	3
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
VHL	0	AR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen S (2013), Chen S (2013), Wang J (2014), Wang J (2014)	4
MDC1	8	KPNB1	3	affinity chromatography technology	Woods NT (2012)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
PARP1	3	UBE2I	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, enzymatic study	Masson M (1997), Masson M (1997), Masson M (1997), Zilio N (2013), Matafora V (2009), Zilio N (2013), Gocke CB (2005)	7
AR	3	NEFL	1	bioid	Lempiaeinen JK (2017)	1
MPRIP	2	PIAS4	5	two hybrid	Wang J (2011)	1
PIAS4	5	SERPINA5	3	two hybrid	Wang J (2011)	1
SUMO2	0	ALDOA	0	biochemical	Wan C (2015)	1
MDC1	8	SERBP1	2	affinity chromatography technology	Woods NT (2012)	1
KPNB1	3	SMAD3	1	pull down, affinity chromatography technology	Xiao Z (2000), Xiao Z (2000)	2
SH3GL3	1	PIAS4	5	two hybrid	Goehler H (2004)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
ERBB4	5	PIAS4	5	affinity chromatography technology	Sundvall M (2012)	1
TRIM27	2	PIAS2	2	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
PARP1	3	PIAS4	5	affinity chromatography technology, pull down, pull down, enzymatic study	Martin N (2009), Martin N (2009), Martin N (2009), Ryu H (2010)	4
BRCA1	7	UBE2K	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Shabbeer S (2013)	6
HNF4A	2	TP53	0	pull down, affinity chromatography technology	Maeda Y (2002), Huttlin EL (2017)	2
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
SUMO1	0	PIAS2	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid	Lee BH (2003), Stehmeier P (2009), Wang J (2011), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	6
TRIM27	2	PIAS4	5	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
HNRNPL	3	PDE4D	4	affinity chromatography technology	Fei T (2017)	1
PIAS4	5	SMAD6	9	two hybrid, affinity chromatography technology	Imoto S (2003), Imoto S (2003)	2
ELAVL1	0	MDC1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	HERC2	9	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wu W (2010), Wu W (2010), Wu W (2010), Peng Y (2015)	4
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
HDAC1	4	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Simonsson M (2005), Simonsson M (2005), Laganiere J (2005)	4
PIAS4	5	KNTC1	4	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Ryu H (2010), Ryu H (2010), Ryu H (2010), Ryu H (2010)	4
OPTN	1	IKBKG	0	affinity chromatography technology	Nakazawa S (2016)	1
CHD3	19	SUMO1	0	two hybrid, pull down	Minty A (2000), Goodarzi AA (2011)	2
SUMO2	0	PIAS4	5	pull down, two hybrid, two hybrid, pull down, pull down	Goehler H (2004), Goehler H (2004), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
VHL	0	IMPDH2	3	affinity chromatography technology	Ewing RM (2007)	1
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
ELAVL1	0	ZHX1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
KPNB1	3	PTN	0	two hybrid	Goehler H (2004)	1
PIAS4	5	FANCA	5	affinity chromatography technology	Karras GI (2017)	1
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
SKIL	3	CHD3	19	two hybrid	Colland F (2004)	1
GADD45G	0	PDE4DIP	10	two hybrid	Vinayagam A (2011)	1
PDE4DIP	10	PDE4D	4	two hybrid, affinity chromatography technology	Verde I (2001), Verde I (2001)	2
HNRNPUL1	1	PIAS4	5	two hybrid	Wang J (2011)	1
PRKCZ	5	PIAS4	5	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Heo KS (2011), Heo KS (2011), Lear T (2016), Lear T (2016)	4
KPNB1	3	SUMO1	0	affinity chromatography technology	Hein MY (2015)	1
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
IMMT	0	PIAS4	5	two hybrid	Goehler H (2004)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
SMAD1	0	OAZ1	2	two hybrid	Gruendler C (2001)	1
PIAS2	2	SMAD4	9	pull down	Li X (2006)	1
SMAD2	5	TGM2	2	two hybrid	Colland F (2004)	1
KRT18	2	PDE4DIP	10	two hybrid	Wang J (2011)	1
ELAVL1	0	KPNB1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD2	5	KPNB1	3	two hybrid	Colland F (2004)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
FANCA	5	FANCD2	3	affinity chromatography technology, affinity chromatography technology	Huard CC (2013), Huard CC (2013)	2
CHD3	19	PRPF40A	5	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
VIM	0	ZHX1	1	two hybrid	Goehler H (2004)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
IMMT	0	PDE4DIP	10	two hybrid	Vinayagam A (2011)	1
SMAD4	9	IRF3	4	affinity chromatography technology	Qing J (2004)	1
TRIM32	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
SERBP1	2	CHD3	19	two hybrid, pull down, pull down, two hybrid	Lemos TA (2003), Lemos TA (2003), Lemos TA (2003), Stelzl U (2005)	4
MECOM	4	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kurokawa M (1998), Kurokawa M (1998), Alliston T (2005), Alliston T (2005)	4
PIAS4	5	PDE4A	1	enzymatic study	Li X (2010)	1
SMAD7	1	LEF1	3	affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Cui Q (2005)	2
UBE2I	0	TCF4	26	enzymatic study	Brandt M (2013)	1
CHD3	19	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
BARD1	4	UBE2K	0	pull down	David Y (2011)	1
TP53BP1	3	KPNB1	3	affinity chromatography technology	Woods NT (2012)	1
BARD1	4	KPNB1	3	affinity chromatography technology	Woods NT (2012)	1
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
ELAVL1	0	LAMP2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SUMO2	0	TOP2A	2	pull down	Ouyang J (2009)	1
HTT	14	UBE2K	0	two hybrid, two hybrid, pull down, two hybrid	Faber PW (1998), Kalchman MA (1996), Kalchman MA (1996), Suter B (2013)	4
SMAD3	1	IRF7	2	pull down, affinity chromatography technology, imaging technique	Qing J (2004), Qing J (2004), Qing J (2004)	3
SUMO2	0	VIM	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
TADA3	0	PIAS4	5	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
ELAVL1	0	PARP1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	CEBPD	0	enzymatic study	Wang JM (2006)	1
PHGDH	4	TCERG1	3	biochemical	Havugimana PC (2012)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
LEF1	3	HDAC1	4	affinity chromatography technology	Billin AN (2000)	1
MECOM	4	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Vinatzer U (2001), Vinatzer U (2001), Chakraborty S (2001)	3
TP53	0	PIAS2	2	pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique	Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014)	6
SMAD4	9	MECOM	4	pull down	Alliston T (2005)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
VHL	0	PARP1	3	affinity chromatography technology	Lai Y (2011)	1
BARD1	4	CHD3	19	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
ELAVL1	0	MECOM	4	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC2	1	TOP2A	2	affinity chromatography technology	Tsai SC (2000)	1
TP53BP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Matsuoka S (2007), Wang B (2002), Bohgaki T (2011), Ertych N (2016)	4
FANCI	1	IMPDH2	3	biochemical	Wan C (2015)	1
SMAD4	9	UBE2I	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Chang CC (2005), Lin X (2003), Colland F (2004), Wang J (2011), Wang J (2011)	6
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
IKBKG	0	PIAS4	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mabb AM (2006), Mabb AM (2006), Wu ZH (2008), Mohanty S (2014), Wu Z (2015)	5
TCF4	26	PIAS4	5	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ravasi T (2010), Ihara M (2005), Ihara M (2005), Yamamoto H (2003)	4
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
ETS1	4	SMAD3	1	imaging technique	Chen TC (2014)	1
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
SUMO2	0	HDAC2	1	pull down	Ouyang J (2009)	1
BARD1	4	PRPF40A	5	affinity chromatography technology	Woods NT (2012)	1
TP53BP1	3	UBE2I	0	imaging technique	Galanty Y (2009)	1
PIAS4	5	PDE4D	4	enzymatic study	Li X (2010)	1
HNF4A	2	SMAD3	1	affinity chromatography technology, pull down	Kardassis D (2000), Kardassis D (2000)	2
CHD3	19	NEFL	1	two hybrid	Goehler H (2004)	1
REV1	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
BRCA1	7	PIAS4	5	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
PIAS4	5	TICAM1	3	affinity chromatography technology	Zhang J (2004)	1
HDAC1	4	TRIM27	2	imaging technique, affinity chromatography technology	Kato T (2009), Shimono Y (2003)	2
PIAS4	5	HDAC2	1	pull down	Gross M (2004)	1
BRCA1	7	SUMO1	0	fluorescent resonance energy transfe, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Park MA (2008), Park MA (2008), Park MA (2008), Ertych N (2016)	5
UBE2K	0	PIAS4	5	two hybrid	Goehler H (2004)	1
PIAS4	5	IRF3	4	affinity chromatography technology	Zhang J (2004)	1
IL15RA	2	PIAS4	5	two hybrid	Wang J (2011)	1
SMAD4	9	PRPF40A	5	two hybrid	Colland F (2004)	1
CALCOCO2	0	IKBKG	0	two hybrid	Wang J (2011)	1
IMPDH2	3	PIAS4	5	two hybrid	Goehler H (2004)	1
CALCOCO2	0	PIAS4	5	two hybrid	Rual JF (2005)	1
TADA3	0	MAGEH1	0	two hybrid	Goehler H (2004)	1
PIAS4	5	FANCI	1	affinity chromatography technology	Gibbs-Seymour I (2015)	1
HTT	14	MAP1LC3A	0	affinity chromatography technology	Filimonenko M (2010)	1
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
ZNF512B	2	VHL	0	two hybrid	Colland F (2004)	1
PIAS4	5	HERC2	9	affinity chromatography technology	Rendtlew Danielsen J (2012)	1
ETS1	4	AR	3	imaging technique	Chen TC (2014)	1
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
HNRNPL	3	BARD1	4	affinity chromatography technology	Fei T (2017)	1
BRCA1	7	EIF5B	2	two hybrid, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
UBE2I	0	ZHX1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Chen S (2013), Chen S (2013), Chen S (2013)	4
VHL	0	KNTC1	4	affinity chromatography technology	Ewing RM (2007)	1
ZNF512B	2	TGM2	2	two hybrid	Colland F (2004)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
SATB1	1	SUMO1	0	two hybrid	Tan JA (2008)	1
PIAS4	5	HIC1	1	imaging technique	Sun L (2013)	1
MDC1	8	TP53BP1	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, imaging technique, affinity chromatography technology	Eliezer Y (2009), Eliezer Y (2009), Eliezer Y (2009), Wood JL (2007), Stewart GS (2003), Stewart GS (2003)	6
SUMO2	0	HDAC1	4	pull down	Ouyang J (2009)	1
PIAS4	5	FANCD2	3	affinity chromatography technology	Gibbs-Seymour I (2015)	1
CHD3	19	IMMT	0	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
ZHX1	1	PRPF40A	5	two hybrid	Goehler H (2004)	1
SATB1	1	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yasui D (2002), Yasui D (2002), Yasui D (2002), Pavan Kumar P (2006), Pavan Kumar P (2006), Kumar PP (2005)	6
LEF1	3	SMAD4	9	pull down	Labbe E (2000)	1
MAP1LC3A	0	OPTN	1	two hybrid, affinity chromatography technology, pull down, pull down	Wild P (2011), Wild P (2011), Liu Z (2014), Wild P (2011)	4
PARP1	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hassa PO (2005), Hassa PO (2005), Hang CT (2010), Rajamohan SB (2009)	4
SUMO2	0	IRF7	2	imaging technique	Chang PC (2013)	1
PIAS4	5	PRPF40A	5	two hybrid	Goehler H (2004)	1
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
KRT18	2	PIAS4	5	two hybrid	Wang J (2011)	1
TP53	0	EIF5B	2	affinity chromatography technology	Horikawa I (2014)	1
PIAS4	5	MECOM	4	affinity chromatography technology, affinity chromatography technology	Singh S (2013), Singh S (2013)	2
LAMP2	0	PIAS4	5	two hybrid	Wang J (2011)	1
PIAS4	5	TOP2A	2	enzymatic study	Ryu H (2010)	1
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
UBE2K	0	PRPF40A	5	two hybrid	Vinayagam A (2011)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
PIAS4	5	IRF7	2	affinity chromatography technology	Zhang J (2004)	1
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
TP53	0	TGM2	2	affinity chromatography technology, affinity chromatography technology	Kang JH (2016), Kang JH (2016)	2
ZMIZ2	1	AR	3	affinity chromatography technology, two hybrid	Huang CY (2005), Huang CY (2005)	2
SMAD2	5	MECOM	4	pull down	Alliston T (2005)	1
FTH1	0	PIAS4	5	two hybrid	Wang J (2011)	1
PIAS4	5	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
FANCI	1	FANCD2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid	Yuan F (2009), Ishiai M (2008), Sims AE (2007), Rego MA (2012), Longerich S (2014), Polito D (2014), Wang D (2016), Oka Y (2015), Oka Y (2015), Oka Y (2015), Oka Y (2015), Unno J (2014), Long DT (2011), Sato K (2014), Sato K (2014), Takahashi D (2014), Gwon GH (2014), Lossaint G (2013), Siddiqui MQ (2017), Inano S (2017)	20
UBE2K	0	TRIM27	2	two hybrid	Markson G (2009)	1
ELAVL1	0	FANCD2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ETS1	4	EIF5B	2	pull down	Miyamoto-Sato E (2010)	1
KPNB1	3	PIAS4	5	two hybrid	Goehler H (2004)	1
MDC1	8	HERC2	9	affinity chromatography technology	Bekker-Jensen S (2010)	1
SMAD4	9	CEBPD	0	pull down, affinity chromatography technology	Choy L (2003), Choy L (2003)	2
ELAVL1	0	SERBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
HNRNPL	3	UBE2K	0	affinity chromatography technology	Fei T (2017)	1
PRPF40A	5	MAP1LC3A	0	two hybrid	Goehler H (2004)	1
IMMT	0	LRIF1	3	two hybrid	Goehler H (2004)	1
SMAD1	0	MECOM	4	pull down	Alliston T (2005)	1
TADA3	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang T (2001), Gamper AM (2008), Sekaric P (2007), Fogeron ML (2013), Nag A (2007), Nag A (2007)	6
PTN	0	PIAS4	5	two hybrid	Goehler H (2004)	1
HTT	14	IKBKG	0	pull down	Khoshnan A (2004)	1
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
TADA3	0	AR	3	pull down	Li CW (2010)	1
PDE4DIP	10	PIAS4	5	two hybrid	Wang J (2011)	1
SUMO2	0	CHD3	19	two hybrid, two hybrid, two hybrid, unspecified method	Stelzl U (2005), Vinayagam A (2011), Goehler H (2004), Garvin AJ (2013)	4
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
HDAC2	1	VHL	0	pull down, affinity chromatography technology, genetic interference	Mahon PC (2001), Hwang IY (2012), Shen JP (2017)	3
ESRRA	2	PIAS4	5	two hybrid	Wang J (2011)	1
HNRNPUL1	1	PRPF40A	5	two hybrid, two hybrid	Stelzl U (2005), Colland F (2004)	2
ELAVL1	0	ETS1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	LEF1	3	affinity chromatography technology	Cui Q (2005)	1
FANCA	5	ALDOA	0	two hybrid	Reuter TY (2003)	1
OAZ1	2	PIAS4	5	two hybrid	Wang J (2011)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
HNRNPL	3	PIAS4	5	affinity chromatography technology	Fei T (2017)	1
SMAD2	5	IRF3	4	affinity chromatography technology	Qing J (2004)	1
PIAS2	2	PIAS4	5	two hybrid	Wang J (2011)	1
TP53	0	TP53BP1	3	x-ray crystallography, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Derbyshire DJ (2002), Sengupta S (2004), Sengupta S (2004), Ekblad CM (2004), Lo KW (2005), Joo WS (2002), Derbyshire DJ (2002), Iwabuchi K (1994), Iwabuchi K (1994), Iwabuchi K (1994), Roy S (2010), Dai C (2011), Tembe V (2015), Cuella-Martin R (2016), Cuella-Martin R (2016), Tong Q (2015), Tong Q (2015)	17
KNTC1	4	ZW10	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Chan GK (2000), Ryu H (2010), Havugimana PC (2012), Kops GJ (2005), Wan C (2015)	5
PIAS2	2	PLAG1	2	pull down	Van Dyck F (2004)	1
MDC1	8	TP53	0	affinity chromatography technology	Xu X (2003)	1
PIAS4	5	MDC1	8	enzymatic study	Yin Y (2012)	1
HERC2	9	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Bai B (2016)	4
NEFL	1	VIM	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Goehler H (2004), Huttlin EL (2017), Boldt K (2016)	3
TP53	0	FTH1	0	affinity chromatography technology	Fogeron ML (2013)	1
CHD3	19	KPNB1	3	two hybrid	Goehler H (2004)	1
SMAD3	1	CEBPD	0	pull down, affinity chromatography technology	Choy L (2003), Choy L (2003)	2
IKBKG	0	GADD45G	0	pull down	Fenner BJ (2010)	1
VIM	0	PIAS4	5	two hybrid	Goehler H (2004)	1
PIAS4	5	MAP1LC3A	0	two hybrid	Goehler H (2004)	1
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
CHD3	19	TCERG1	3	two hybrid	Goehler H (2004)	1
BTAF1	6	PIAS4	5	two hybrid	Wang J (2011)	1
TP53	0	TCF4	26	pull down, affinity chromatography technology	Kotlyar M (2015), Li X (2015)	2
PIAS4	5	LEF1	3	two hybrid, pull down, affinity chromatography technology	Sachdev S (2001), Sachdev S (2001), Sachdev S (2001)	3
FANCD2	3	REV1	1	affinity chromatography technology	Yang Y (2015)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SUMO2	0	PIAS2	2	two hybrid, two hybrid, pull down, pull down, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
ELAVL1	0	SUMO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
TGM2	2	PIAS4	5	affinity chromatography technology, affinity chromatography technology	Luciani A (2009), Luciani A (2009)	2
TP53	0	KPNB1	3	affinity chromatography technology, pull down	Akakura S (2001), Akakura S (2001)	2
UBE2I	0	TOP2A	2	pull down, affinity chromatography technology, enzymatic study	Mao Y (2000), Mao Y (2000), Matafora V (2009)	3
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
REV1	1	TP53	0	affinity chromatography technology	Shim HS (2015)	1
BARD1	4	PTN	0	two hybrid	Goehler H (2004)	1
PARP1	3	IMMT	0	affinity chromatography technology, affinity chromatography technology	Rossi MN (2009), Rossi MN (2009)	2
KPNB1	3	SMAD4	9	affinity chromatography technology	Xiao Z (2000)	1
MAGEH1	0	PIAS4	5	two hybrid	Goehler H (2004)	1
BARD1	4	TCERG1	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
HIC1	1	MECOM	4	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Pradhan AK (2014), Pradhan AK (2014), Pradhan AK (2014)	3
PIAS4	5	AREL1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, unspecified method	Lear T (2016), Lear T (2016), Lear T (2016), Lear T (2016), Lear T (2016)	5
SMAD4	9	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
ELAVL1	0	HNRNPUL1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GADD45G	0	LRIF1	3	two hybrid	Goehler H (2004)	1
ACTN1	5	PIAS4	5	two hybrid	Wang J (2011)	1
CLK1	1	IMPDH2	3	enzymatic study	Lipp JJ (2015)	1
SUMO1	0	ZHX1	1	two hybrid	Hecker CM (2006)	1
TCERG1	3	PIAS4	5	two hybrid	Goehler H (2004)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
HNRNPL	3	PRKCZ	5	affinity chromatography technology	Fei T (2017)	1
LEF1	3	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005)	3
HTT	14	PRPF40A	5	two hybrid, pull down, two hybrid	Faber PW (1998), Faber PW (1998), Goehler H (2004)	3
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
CHD3	19	LRIF1	3	two hybrid	Goehler H (2004)	1
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
HTT	14	OPTN	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid	Faber PW (1998), Hattula K (2001), Hattula K (2001), Hattula K (2001), Suter B (2013)	5
MDC1	8	IMMT	0	affinity chromatography technology	Woods NT (2012)	1
TP53	0	TOP2A	2	affinity chromatography technology, pull down, genetic interference	Cowell IG (2000), Cowell IG (2000), Xie L (2013)	3
SMAD4	9	SUMO1	0	affinity chromatography technology	Lee PS (2003)	1
HNRNPL	3	BTAF1	6	affinity chromatography technology	Fei T (2017)	1
BRCA1	7	TOP2A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lou Z (2005), Lou Z (2005), Lou Z (2005), Hill SJ (2014)	4
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
HNRNPL	3	AR	3	affinity chromatography technology	Fei T (2017)	1
FANCA	5	TCERG1	3	two hybrid	Reuter TY (2003)	1
BARD1	4	ZHX1	1	two hybrid	Goehler H (2004)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
UBE2I	0	TCERG1	3	enzymatic study	Gocke CB (2005)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
MDC1	8	BARD1	4	affinity chromatography technology	Lou Z (2003)	1
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
PTN	0	CHD3	19	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
BRCA1	7	HNRNPUL1	1	affinity chromatography technology	Ertych N (2016)	1
PHF11	0	PIAS4	5	two hybrid	Wang J (2011)	1
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
ELAVL1	0	PDE4DIP	10	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	PIAS4	5	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	ALDOA	0	affinity chromatography technology	Ertych N (2016)	1
PIAS4	5	LRIF1	3	two hybrid	Goehler H (2004)	1
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
PIAS4	5	VHL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Cai Q (2010), Cai Q (2010), Chien W (2013), Chien W (2013), Cai Q (2010)	5
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
PRPF40A	5	UBE2I	0	two hybrid	Colland F (2004)	1
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
SATB1	1	PIAS4	5	two hybrid, two hybrid	Tan JA (2010), Tan JA (2008)	2
SKIL	3	PIAS4	5	two hybrid	Colland F (2004)	1
SATB1	1	CHD3	19	affinity chromatography technology, biochemical	Yasui D (2002), Yasui D (2002)	2
SMAD2	5	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
MDC1	8	FANCD2	3	affinity chromatography technology	Stewart GS (2003)	1
HDAC1	4	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong JK (1998), Tong JK (1998), Kuzmichev A (2002), Sun JM (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Xue Y (1998), Havugimana PC (2012), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	12
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
BARD1	4	HNRNPUL1	1	affinity chromatography technology	Woods NT (2012)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
HDAC2	1	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Hakimi MA (2003), Tong JK (1998), Tong JK (1998), Hakimi MA (2002), Sun JM (2007), Xue Y (1998), Xue Y (1998), Xue Y (1998), Havugimana PC (2012), Joshi P (2013)	10
SERBP1	2	VIM	0	two hybrid	Stelzl U (2005)	1
PARP1	3	HDAC2	1	affinity chromatography technology, pull down, affinity chromatography technology	Hassa PO (2005), Hassa PO (2005), Hang CT (2010)	3
BRCA1	7	IMPDH2	3	affinity chromatography technology	Ertych N (2016)	1
ETS1	4	UBE2I	0	two hybrid, pull down	Hahn SL (1997), Hahn SL (1997)	2
TP53BP1	3	PIAS4	5	imaging technique	Galanty Y (2009)	1
ELAVL1	0	SMAD6	9	affinity chromatography technology	Abdelmohsen K (2009)	1
PRPF40A	5	TCERG1	3	biochemical	Havugimana PC (2012)	1
PIAS4	5	ZMIZ2	1	affinity chromatography technology	Peng Y (2010)	1
HDAC1	4	VHL	0	pull down, affinity chromatography technology	Mahon PC (2001), Hwang IY (2012)	2
CHD3	19	PIAS4	5	two hybrid	Goehler H (2004)	1
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
PIAS4	5	PLAG1	2	pull down	Van Dyck F (2004)	1
SUMO2	0	BRCA1	7	affinity chromatography technology	Hu X (2012)	1
FANCD2	3	PARP1	3	genetic interference	Ward TA (2017)	1
HERC2	9	FTH1	0	affinity chromatography technology, affinity chromatography technology	Galligan JT (2015), Galligan JT (2015)	2
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
BARD1	4	PIAS4	5	two hybrid	Goehler H (2004)	1
SMAD2	5	HDAC2	1	pull down	Miyamoto-Sato E (2010)	1
CA10	5	PIAS4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
AR	3	PIAS2	2	two hybrid, two hybrid, pull down, pull down	Kotaja N (2000), Moilanen AM (1999), Moilanen AM (1999), Kotaja N (2000)	4
TCERG1	3	HTT	14	pull down, two hybrid	Holbert S (2001), Goehler H (2004)	2
IKBKG	0	KRT18	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TP53	0	IRF7	2	two hybrid	Chen J (2008)	1
UBE2I	0	TRIM27	2	two hybrid, affinity chromatography technology	Markson G (2009), Chu Y (2011)	2
CLK1	1	PIAS4	5	two hybrid	Goehler H (2004)	1
BARD1	4	PARP1	3	affinity chromatography technology	Hu Y (2014)	1
PTN	0	GADD45G	0	two hybrid	Goehler H (2004)	1
ELAVL1	0	BTAF1	6	affinity chromatography technology	Abdelmohsen K (2009)	1
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
HDAC1	4	ZNF512B	2	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
SERBP1	2	TP53	0	affinity chromatography technology	Nery FC (2006)	1
REV1	1	PIAS4	5	affinity chromatography technology	Shim HS (2015)	1
IKBKG	0	MPRIP	2	two hybrid	Wang J (2011)	1
CEBPD	0	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lai PH (2008), Turgeon N (2008), Turgeon N (2008), Turgeon N (2008)	4
PIAS2	2	SMAD3	1	pull down	Li X (2006)	1
UBE2I	0	HIC1	1	enzymatic study, affinity chromatography technology	Stankovic-Valentin N (2007), Dehennaut V (2013)	2
VHL	0	TGM2	2	affinity chromatography technology, affinity chromatography technology	Kim DS (2011), Kim DS (2011)	2
SUMO1	0	PIAS4	5	two hybrid	Hecker CM (2006)	1
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
PIAS4	5	EIF5B	2	biochemical	Wan C (2015)	1
TRIM32	2	PIAS4	5	imaging technique, enzymatic study	Albor A (2006), Albor A (2006)	2
ZNF512B	2	SMAD1	0	two hybrid	Colland F (2004)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
VIM	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
NEFL	1	PIAS4	5	two hybrid	Goehler H (2004)	1
SMAD3	1	TGM2	2	two hybrid	Colland F (2004)	1
VHL	0	PRKCZ	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okuda H (1999), Okuda H (1999), Schermer B (2006)	3
HDAC2	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
ETS1	4	PIAS4	5	affinity chromatography technology, affinity chromatography technology	Nishida T (2007), Ji Z (2007)	2
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
PIAS4	5	HNF4A	2	enzymatic study	Yamamoto H (2003)	1
SKIL	3	HDAC1	4	affinity chromatography technology	Nomura T (1999)	1
GADD45G	0	PIAS4	5	two hybrid	Goehler H (2004)	1
BRCA1	7	FANCA	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Folias A (2002), Folias A (2002), Folias A (2002), Suhasini AN (2011)	4
BRCA1	7	ETS1	4	pull down	Chai Y (2001)	1
PARP1	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015)	3
HIC1	1	CHD3	19	affinity chromatography technology	Van Rechem C (2010)	1
HTT	14	SH3GL3	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Sittler A (1998), Sittler A (1998), Sittler A (1998), Goehler H (2004)	4
HDAC1	4	VIM	0	affinity chromatography technology	Terhune SS (2010)	1
AR	3	HNF4A	2	imaging technique	Mulholland DJ (2003)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
ZNF512B	2	PDE4DIP	10	two hybrid	Colland F (2004)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
MDC1	8	PHGDH	4	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	KRT18	2	affinity chromatography technology	Ertych N (2016)	1
CEBPD	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2010), Wang J (2010), Wang J (2010), Wang J (2010)	4
MDC1	8	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Matsuoka S (2007), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Lou Z (2003), Mok MT (2010), Au WW (2005)	7
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
IRF3	4	TICAM1	3	affinity chromatography technology	Liu S (2015)	1
HNF4A	2	UBE2I	0	two hybrid, enzymatic study	Albers M (2005), Zhou W (2012)	2
UBE2I	0	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
SH3GL3	1	VIM	0	two hybrid	Goehler H (2004)	1
OPTN	1	PIAS4	5	two hybrid	Wang J (2011)	1
SMAD3	1	PLAG1	2	two hybrid	Colland F (2004)	1