PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TSC22D1	1	ZC3HC1	1	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	PLK1	0	two hybrid	Vinayagam A (2011)	1
FAM19A3	0	ZC3HC1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIP13	0	ZC3HC1	1	biochemical	Kristensen AR (2012)	1
CDC5L	2	PLK1	0	affinity chromatography technology	Lleres D (2010)	1
ZC3HC1	1	APP	1	pull down	Olah J (2011)	1
CUL1	7	RPL38	0	affinity chromatography technology	Bennett EJ (2010)	1
RPL38	0	ZC3HC1	1	biochemical	Kristensen AR (2012)	1
GTF3C4	0	PLK1	0	affinity chromatography technology	Boldt K (2016)	1
MAPK1	1	TPR	5	enzymatic study	Eblen ST (2003)	1
ZC3HC1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005)	3
FZR1	1	ZC3HC1	1	enzymatic study, affinity chromatography technology	von Klitzing C (2011), von Klitzing C (2011)	2
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
RBX1	2	APP	1	pull down	Olah J (2011)	1
HNRNPA1	1	APP	1	pull down	Olah J (2011)	1
ZC3HC1	1	EHD4	1	biochemical	Kristensen AR (2012)	1
CDC5L	2	TRIP13	0	affinity chromatography technology	Lleres D (2010)	1
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
8339	0	ZC3HC1	1	bioid	Lambert JP (2015)	1
ZC3HC1	1	TPR	5	affinity chromatography technology	Huttlin EL (2017)	1
TNFSF11	0	ZC3HC1	1	two hybrid	Vinayagam A (2011)	1
FAM19A3	0	GRN	2	affinity chromatography technology	Huttlin EL (2017)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
YWHAE	0	ZC3HC1	1	pull down	Satoh J (2006)	1
CUL1	7	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
RPL38	0	EHD4	1	biochemical	Kristensen AR (2012)	1
ZC3HC1	1	SRBD1	5	affinity chromatography technology	Huttlin EL (2017)	1
PFKL	6	ZC3HC1	1	biochemical	Kristensen AR (2012)	1
CDC5L	2	CCNB1	3	affinity chromatography technology	Lleres D (2010)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
GPX7	0	ZC3HC1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	FZR1	1	affinity chromatography technology, affinity chromatography technology	Fukushima H (2013), Fukushima H (2013)	2
GRN	2	ZC3HC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPL38	0	HNRNPA1	1	biochemical	Kristensen AR (2012)	1
PDPK1	0	APP	1	pull down	Olah J (2011)	1
ZC3HC1	1	NXF2B	0	affinity chromatography technology	Huttlin EL (2017)	1
ETNPPL	1	APP	1	pull down	Olah J (2011)	1
AASDHPPT	0	EHD4	1	biochemical	Kristensen AR (2012)	1
ATP6V1C2	1	ZC3HC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZC3HC1	1	CCNB1	3	pull down, affinity chromatography technology, enzymatic study, enzymatic study	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005), Liu YQ (2015)	4
CDC5L	2	ZC3HC1	1	affinity chromatography technology	Lleres D (2010)	1
ALK	8	MAPK1	1	affinity chromatography technology	Crockett DK (2004)	1
YWHAE	0	HNRNPA1	1	affinity chromatography technology	Roy R (2014)	1
CUL1	7	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
8339	0	SRBD1	5	bioid	Lambert JP (2015)	1
ZC3HC1	1	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005), Bassermann F (2005), von Klitzing C (2011), Liu YQ (2015), Liu YQ (2015)	7
HNRNPA1	1	AASDHPPT	0	biochemical	Wan C (2015)	1
MAPK3	4	ZC3HC1	1	enzymatic study	Illert AL (2012)	1
TRIP13	0	AASDHPPT	0	biochemical	Kristensen AR (2012)	1
PFKL	6	APP	1	pull down	Olah J (2011)	1
ZC3HC1	1	RBX1	2	affinity chromatography technology	Bassermann F (2005)	1
CDC5L	2	EHD4	1	affinity chromatography technology	Lleres D (2010)	1
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
ZC3HC1	1	PLK1	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPA1	1	ZC3HC1	1	biochemical	Kristensen AR (2012)	1
PDPK1	0	ZC3HC1	1	two hybrid	Vinayagam A (2011)	1
CDC5L	2	YWHAE	0	affinity chromatography technology	Lleres D (2010)	1
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HNRNPA1	1	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Huttlin EL (2015)	2
ZC3HC1	1	GTF3C4	0	biochemical	Kristensen AR (2012)	1
MINDY3	3	ZC3HC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK1	1	ZC3HC1	1	enzymatic study	Illert AL (2012)	1
ETNPPL	1	ZC3HC1	1	affinity chromatography technology	Huttlin EL (2017)	1
ALK	8	ZC3HC1	1	pull down, affinity chromatography technology, enzymatic study	Ouyang T (2003), Ouyang T (2003), Ouyang T (2003)	3
CDC5L	2	TPR	5	affinity chromatography technology	Lleres D (2010)	1
AASDHPPT	0	ZC3HC1	1	biochemical	Kristensen AR (2012)	1
GTF3C4	0	EHD4	1	biochemical	Kristensen AR (2012)	1
ZC3HC1	1	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lleres D (2010)	2
SASS6	1	ZC3HC1	1	affinity chromatography technology	Huttlin EL (2017)	1