PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	UBE2C	1	affinity chromatography technology	Matsumoto M (2005)	1
ANAPC11	0	UBE2S	2	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Huang NJ (2012), Wang W (2013), Frye JJ (2013), Chang L (2014), Brown NG (2014), Wu T (2010), Sedgwick GG (2013), Fukushima H (2013), Yamaguchi M (2015), Brown NG (2015), Brown NG (2014), Kelly A (2014), Kelly A (2014), Craney A (2016), Zhang S (2016), Williamson A (2011), Qiao R (2016), Brown NG (2016), Li Q (2016)	19
ANAPC2	0	ANAPC10	0	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015)	3
UBE2U	0	TRIM65	1	two hybrid	van Wijk SJ (2009)	1
UBE2S	2	CDC16	2	pull down	Brown NG (2014)	1
UBE2S	2	CDC20	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Williamson A (2009), Williamson A (2009), Brown NG (2014), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016)	7
FZR1	1	UBE2D3	1	pull down	Jin L (2008)	1
ANAPC11	0	E2F1	0	affinity chromatography technology	Nath S (2014)	1
FBXO5	2	ANAPC4	0	pull down, biochemical, affinity chromatography technology	Miller JJ (2006), Chang L (2015), Voets E (2015)	3
CDC27	2	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Hein MY (2015), Qiao R (2016), Qiao R (2016), Boldt K (2016)	18
ANAPC11	0	UBE2D2	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Chang TS (2004), Townsend K (2009), Van Voorhis VA (2014), ODonovan KJ (2010), Tang Z (2001), Tang Z (2001), Vodermaier HC (2003), Shoji S (2014), Brown NG (2014), Brown NG (2015)	10
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
FZR1	1	UBE2K	0	pull down	Jin L (2008)	1
BIRC6	15	ANAPC11	0	affinity chromatography technology	Kikuchi R (2014)	1
NKD2	1	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FZR1	1	UBE2D1	0	pull down	Jin L (2008)	1
CDC16	2	CCNB1	3	affinity chromatography technology	van Zon W (2010)	1
CCNB1	3	ANAPC10	0	affinity chromatography technology	Voets E (2015)	1
CDC27	2	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Dube P (2005), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Gmachl M (2000), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Gmachl M (2000), Kelly A (2014), Craney A (2016), Qiao R (2016)	17
CDC27	2	E2F1	0	affinity chromatography technology	Nath S (2014)	1
ANAPC4	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Izawa D (2011), Di Fiore B (2015), Voets E (2015)	3
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
ANAPC2	0	UBE2D2	0	pull down	Vodermaier HC (2003)	1
MAK	3	FZR1	1	affinity chromatography technology, enzymatic study	Wang LY (2012), Wang LY (2012)	2
FBXO5	2	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Moshe Y (2011), Miller JJ (2006), Miller JJ (2006), Miller JJ (2006), Miller JJ (2006), Huttlin EL (2017)	6
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
CDC20	1	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stewart S (2005), Jia L (2011), Zhang Y (2001), Fogeron ML (2013), Lee SB (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	9
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
BIRC6	15	UBE2D1	0	pull down	Hao Y (2004)	1
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
CDC20	1	ANAPC10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Voets E (2015), Kelly A (2014), Craney A (2016)	4
CDC20	1	CDC16	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kallio MJ (2002), Kallio M (1998), Nilsson J (2008), Hutchins JR (2010), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Listovsky T (2013), Qiao R (2016), Izawa D (2012)	12
ANAPC10	0	ANAPC4	0	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Voets E (2015)	8
ANAPC11	0	UBE2K	0	pull down, pull down, pull down	Bassermann F (2008), Rodrigo-Brenni MC (2007), Van Voorhis VA (2014)	3
FBXO5	2	CDC16	2	affinity chromatography technology, pull down, affinity chromatography technology	Miller JJ (2006), Miller JJ (2006), Hein MY (2015)	3
ANAPC11	0	MLKL	1	two hybrid	Wang J (2011)	1
FZR1	1	PTTG1	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Pfleger CM (2001), Jin L (2008), Tian W (2012), He J (2013), Wang W (2013), Van Voorhis VA (2014), Gmachl M (2000), Wu T (2010), Vodermaier HC (2003), Jeganathan KB (2006), Yamaguchi M (2015), Brown NG (2015), Williamson A (2011), Qiao R (2016), Brown NG (2016)	15
E2F1	0	CCNA2	1	affinity chromatography technology, pull down, affinity chromatography technology	Xu M (1994), Xu M (1994), Schulman BA (1998)	3
ANAPC2	0	ANAPC4	0	biochemical, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Gmachl M (2000), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Boekhout M (2015)	11
CDC20	1	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mansfeld J (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Wolthuis R (2008), Sedgwick GG (2012), Zhang Z (2012), Chang L (2014), Fogeron ML (2013), Hein JB (2014), Hein JB (2014), Voets E (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Izawa D (2012), Izawa D (2012), Izawa D (2012), Izawa D (2012), Salsi V (2016)	25
FZR1	1	ANAPC10	0	unspecified method	Vodermaier HC (2003)	1
CDC16	2	CDC23	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
UBE2D3	1	UBE2C	1	biochemical	Wan C (2015)	1
FBXO5	2	CDC23	3	pull down, affinity chromatography technology	Miller JJ (2006), Hein MY (2015)	2
CCNA2	1	CDC20	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Di Fiore B (2010), Di Fiore B (2010), Di Fiore B (2010), Wolthuis R (2008), Wolthuis R (2008), Ge S (2009), Townsend K (2009), Di Fiore B (2010), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Huttlin EL (2017), Izawa D (2012), Hein JB (2016)	25
UBE2D3	1	RNF111	2	two hybrid, two hybrid, pull down, two hybrid	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Rolland T (2014)	4
CDC27	2	ANAPC10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Kurasawa Y (1999), Kurasawa Y (1999), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015), Hein MY (2015)	13
FBXO5	2	ANAPC11	0	pull down	Miller JJ (2006)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
ANAPC11	0	MAK	3	two hybrid	Wang J (2011)	1
UBE2K	0	CCNB1	3	affinity chromatography technology	Bae Y (2010)	1
CDC20	1	UBC	7	enzymatic study, enzymatic study	Kelly A (2014), Craney A (2016)	2
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2K	0	RNF111	2	two hybrid	Markson G (2009)	1
ANAPC11	0	UBE2D3	1	pull down	Choudhury R (2016)	1
ANAPC11	0	NKD2	1	two hybrid	Wang J (2011)	1
ANAPC11	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
ANAPC11	0	TRIM65	1	two hybrid	Woodsmith J (2012)	1
PTTG1	0	CDC27	2	affinity chromatography technology, pull down, pull down	Jeganathan KB (2006), Miller JJ (2006), Qiao R (2016)	3
UBE2D2	0	CCNB1	3	enzymatic study	Tang Z (2001)	1
ANAPC4	0	CDC16	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Masuda K (2015), Boekhout M (2015), Huttlin EL (2017)	14
ANAPC2	0	CDC23	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003), Hein MY (2015)	4
BIRC6	15	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Kikuchi R (2014), Kikuchi R (2014)	2
ANAPC11	0	ANAPC2	0	pull down, pull down, two hybrid, biochemical, affinity chromatography technology	Tang Z (2001), Tang Z (2001), Ohta T (1999), Lu L (2013), Vodermaier HC (2003)	5
UBE2S	2	UBE2D3	1	affinity chromatography technology	Kuang P (2016)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
BIRC6	15	CDC27	2	affinity chromatography technology	Kikuchi R (2014)	1
UBC	7	ANAPC11	0	x-ray crystallography, pull down	Brown NG (2014), Brown NG (2016)	2
CDC20	1	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	8
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
UBE2S	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, pull down	Williamson A (2009), Williamson A (2009), Williamson A (2009), Williamson A (2009), Williamson A (2009), Wang W (2013), Brown NG (2014), Kelly A (2014)	8
UBE2D1	0	RNF111	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Rolland T (2014)	3
ANAPC11	0	PTTG1	0	enzymatic study, enzymatic study, enzymatic study	Gmachl M (2000), Tang Z (2001), Vodermaier HC (2003)	3
ANAPC4	0	FZR1	1	biochemical, biochemical, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Boekhout M (2015), Huttlin EL (2017)	6
CCNA2	1	CDC27	2	affinity chromatography technology	Mateo F (2009)	1
FBXO5	2	ANAPC2	0	pull down	Miller JJ (2006)	1
FZR1	1	ANAPC11	0	affinity chromatography technology, pull down, unspecified method	Bassermann F (2008), Vodermaier HC (2003), Vodermaier HC (2003)	3
ANAPC11	0	CUL5	1	two hybrid	Ohta T (1999)	1
ANAPC2	0	CDC16	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
ANAPC11	0	ANAPC11	0	enzymatic study, enzymatic study	Gmachl M (2000), Tang Z (2001)	2
TRIM25	5	FZR1	1	affinity chromatography technology	Choudhury NR (2017)	1
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
ANAPC11	0	CDC16	2	biochemical	Lu L (2013)	1
FZR1	1	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Stewart S (2005), Wen H (2010), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Huttlin EL (2017)	6
CUL5	1	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Zhang X (2017)	2
UBE2S	2	CDC23	3	affinity chromatography technology, pull down, pull down	Wang W (2013), Brown NG (2014), Kelly A (2014)	3
CDC27	2	CDC16	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Ollendorff V (1997), Kallio M (1998), Gmachl M (2000), Kraft C (2003), Li Y (1997), Lara-Gonzalez P (2011), Binne UK (2007), van Zon W (2010), Dube P (2005), Holzmann J (2011), Hayes MJ (2006), Tugendreich S (1995), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Kelly A (2014), Listovsky T (2013), Qiao R (2016), Huttlin EL (2017), Boldt K (2016)	22
ANAPC4	0	CDC23	3	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015)	8
TRIM25	5	UBE2S	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
ANAPC10	0	CDC16	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Kurasawa Y (1999), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	4
ANAPC11	0	283556	0	pull down	Gmachl M (2000)	1
TRIM25	5	CUL5	1	affinity chromatography technology	Choudhury NR (2017)	1
E2F1	0	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Budhavarapu VN (2012), Budhavarapu VN (2012), Budhavarapu VN (2012), Singh RK (2017)	4
CDC27	2	ANAPC11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Dube P (2005), Lu L (2013), Gmachl M (2000), Vodermaier HC (2003), Craney A (2016)	8
UBC	7	BIRC6	15	affinity chromatography technology	Matsumoto M (2005)	1
CDC20	1	PTTG1	0	enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Braunstein I (2007), Eytan E (2006), Pfleger CM (2001), Kim HS (2009), Kwan PS (2013), Tian W (2012), Van Voorhis VA (2014), Lara-Gonzalez P (2011), Wu T (2010), Izawa D (2014), Hellmuth S (2014), Wu T (2010), Shoji S (2014), Lara-Gonzalez P (2011), Di Fiore B (2015), Lee SB (2015), Qiao R (2016), Alfieri C (2016), Izawa D (2012), Jia L (2016)	20
CCNB1	3	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Zon W (2010), Izawa D (2011), Voets E (2015), Voets E (2015)	4
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
FBXO5	2	FZR1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hsu JY (2002), Hsu JY (2002), Reimann JD (2001), Miller JJ (2006), Huttlin EL (2017)	5
ANAPC11	0	CCNB1	3	pull down	Frye JJ (2013)	1
FZR1	1	UBE2C	1	pull down, pull down, enzymatic study	Jin L (2008), Williamson A (2009), Williamson A (2011)	3
ANAPC11	0	UBE2C	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Wu T (2010), Ke PY (2007), Jia L (2011), Braunstein I (2007), van Zon W (2010), Eytan E (2006), Ping Z (2012), Townsend K (2009), Huang NJ (2012), Chow C (2011), Zhang Z (2012), Bassermann F (2008), Wang W (2013), Frye JJ (2013), Han JS (2013), Chang L (2014), Lara-Gonzalez P (2011), He J (2013), Lau AW (2013), Han JS (2014), Sedgwick GG (2013), von Klitzing C (2011), Tang Z (2001), Shoji S (2014), Fukushima H (2013), Yamaguchi M (2015), Sajman J (2015), Brown NG (2015), Brown NG (2014), Cao J (2015), Zhang S (2016), Williamson A (2011), Qiao R (2016), Alfieri C (2016), Brown NG (2016), Li Q (2016), Izawa D (2012)	37
CDC20	1	ANAPC11	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Nilsson J (2008), Chen TC (2014), Lee SB (2015), Alfieri C (2016)	4
UBE2S	2	ANAPC2	0	affinity chromatography technology, pull down, pull down, pull down	Wang W (2013), Brown NG (2014), Brown NG (2014), Kelly A (2014)	4
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
ANAPC4	0	ANAPC11	0	affinity chromatography technology, biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Mansfeld J (2011), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015)	6
ANAPC11	0	UBE2D1	0	pull down, pull down, pull down, pull down	Wu T (2010), Townsend K (2009), Summers MK (2009), Cao J (2015)	4
CCNA2	1	FZR1	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Jin L (2008), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Williamson A (2011), Huttlin EL (2017), Choudhury R (2016)	8
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
ANAPC2	0	UBE2C	1	pull down, biochemical, pull down, x-ray crystallography, pull down	Tang Z (2001), Reddy SK (2007), Tang Z (2001), Brown NG (2015), Brown NG (2015)	5
CDC20	1	CCNB1	3	enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Garnett MJ (2009), ODonovan KJ (2010), Ke PY (2004), Braunstein I (2007), van Zon W (2010), van Zon W (2010), Pfleger CM (2001), Wolthuis R (2008), Kwan PS (2013), Tian W (2012), Han JS (2013), Lim HJ (2013), Han JS (2014), Brown NG (2014), Townsend K (2009), Sedgwick GG (2013), Lara-Gonzalez P (2011), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Wu T (2010), Uzunova K (2012), Shoji S (2014), Sedgwick GG (2013), Lara-Gonzalez P (2011), Diaz-Martinez LA (2015), Brown NG (2015), Lischetti T (2014), Tipton AR (2013), Lee SB (2015), Lee SB (2015), Jia L (2016)	33
ANAPC11	0	CCNA2	1	affinity chromatography technology	Kikuchi R (2014)	1
TRIM25	5	ANAPC11	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2S	2	FBXO5	2	affinity chromatography technology	Wang W (2013)	1
ANAPC10	0	CDC23	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
FZR1	1	CDC23	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
FZR1	1	CDC16	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
ANAPC11	0	CDC23	3	biochemical	Lu L (2013)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2U	0	ANAPC11	0	two hybrid	van Wijk SJ (2009)	1
CDC20	1	E2F1	0	affinity chromatography technology, affinity chromatography technology	Nath S (2014), Peart MJ (2010)	2
UBE2S	2	UBE2C	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
ANAPC11	0	CAPN11	1	two hybrid	Wang J (2011)	1
ANAPC11	0	ZAP70	5	two hybrid	Wang J (2011)	1
ANAPC2	0	PTTG1	0	enzymatic study, pull down	Vodermaier HC (2003), Qiao R (2016)	2
UBE2C	1	CDC20	1	biochemical, pull down	Reddy SK (2007), Garnett MJ (2009)	2
FBXO5	2	CDC20	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu JY (2002), Hsu JY (2002), Reimann JD (2001), Reimann JD (2001), Voets E (2015)	5
UBE2S	2	CDC27	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Williamson A (2009), Brown NG (2014), Kelly A (2014), Craney A (2016)	4
CCNB1	3	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jeganathan KB (2006), Farhana L (2002), van Zon W (2010), Miller JJ (2006), Voets E (2015)	5
UBE2S	2	ANAPC4	0	pull down, pull down	Brown NG (2014), Brown NG (2014)	2
ANAPC11	0	ANAPC10	0	pull down	Tang Z (2001)	1