PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VIM	0	MTA1	3	affinity chromatography technology	Hein MY (2015)	1
TP53	0	RPS14	0	affinity chromatography technology	Fogeron ML (2013)	1
FECH	1	NELFE	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	PRMT5	3	affinity chromatography technology	Emdal KB (2015)	1
NELFCD	3	RPS26	1	affinity chromatography technology	Ewing RM (2007)	1
NELFCD	3	GSTM4	0	two hybrid	Stelzl U (2005)	1
NELFE	0	NELFA	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Narita T (2003), Narita T (2003), Narita T (2003), Narita T (2003), Mak AB (2010), Mak AB (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
NELFCD	3	MCM7	5	affinity chromatography technology	Ewing RM (2007)	1
TP53	0	NELFCD	3	genetic interference	Xie L (2013)	1
NCBP1	7	NELFCD	3	affinity chromatography technology	Hein MY (2015)	1
NELFA	2	NELFCD	3	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Narita T (2003), Mak AB (2010), Mak AB (2010), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	6
MCM7	5	UBE3A	4	pull down, affinity chromatography technology	Kuehne C (1998), Kuehne C (1998)	2
NTRK1	1	PHB2	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	COPB2	3	affinity chromatography technology	Emdal KB (2015)	1
ARAF	0	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NTRK1	1	EPRS	2	affinity chromatography technology	Emdal KB (2015)	1
NELFA	2	ATP1A1	9	affinity chromatography technology	Mak AB (2010)	1
HYPK	2	NELFCD	3	affinity chromatography technology	Choudhury KR (2012)	1
HYPK	2	VIM	0	affinity chromatography technology, affinity chromatography technology	Choudhury KR (2012), Choudhury KR (2012)	2
NETO2	1	NELFCD	3	affinity chromatography technology	Hein MY (2015)	1
RPS11	0	RPS14	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NELFE	0	NELFB	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lehner B (2004), Narita T (2003), Narita T (2003), Narita T (2003), Mak AB (2010), Mak AB (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
NTRK1	1	ATP1A1	9	affinity chromatography technology	Emdal KB (2015)	1
NELFCD	3	COX4I1	4	affinity chromatography technology	Ewing RM (2007)	1
FECH	1	NELFB	7	affinity chromatography technology	Huttlin EL (2017)	1
NELFCD	3	NELFE	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Narita T (2003), Narita T (2003), Narita T (2003), Mak AB (2010), Mak AB (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
COX5B	0	COX2	0	biochemical	Wan C (2015)	1
NCBP1	7	SMAD4	9	affinity chromatography technology	Cheng H (2006)	1
GSTM4	0	TP53	0	two hybrid	Stelzl U (2005)	1
PRMT5	3	NCBP1	7	biochemical	Wan C (2015)	1
CCAR2	9	PRMT5	3	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
NELFCD	3	MTA1	3	two hybrid	Stelzl U (2005)	1
RPS11	0	RPS26	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FOXL1	0	NELFCD	3	affinity chromatography technology	Li X (2015)	1
NTRK1	1	NCBP1	7	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	MTA1	3	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yao YL (2003), Li DQ (2010), Moon HE (2007), Moon HE (2007), Li DQ (2009), Li DQ (2009)	6
POLR2C	0	NELFB	7	affinity chromatography technology	Ayguen O (2008)	1
NELFCD	3	NELFB	7	affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Narita T (2003), Mak AB (2010)	3
NELFCD	3	COX5B	0	affinity chromatography technology	Ewing RM (2007)	1
FOXL1	0	EIF4G1	9	affinity chromatography technology	Li X (2015)	1
VIM	0	NELFCD	3	affinity chromatography technology	Hein MY (2015)	1
POLR2C	0	PRMT5	3	affinity chromatography technology	Ayguen O (2008)	1
NELFCD	3	ARPC4	0	two hybrid	Stelzl U (2005)	1
NELFCD	3	SERF2	0	two hybrid	Stelzl U (2005)	1
NCBP1	7	NELFA	2	affinity chromatography technology	Hein MY (2015)	1
PHB2	1	COX4I1	4	biochemical	Wan C (2015)	1
SMAD4	9	NELFCD	3	two hybrid	Colland F (2004)	1
UBE3A	4	EIF4G1	9	two hybrid	Vinayagam A (2011)	1
EIF4G1	9	NCBP1	7	affinity chromatography technology, affinity chromatography technology	McKendrick L (2001), Kroczynska B (2014)	2
ARAF	0	NELFCD	3	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid	Yuryev A (2003), Yin XL (2002), Yin XL (2002), Yin XL (2002), Wang J (2011)	5
NELFCD	3	PRMT5	3	two hybrid	Weimann M (2013)	1
NELFCD	3	COX2	0	affinity chromatography technology	Ewing RM (2007)	1
POLR2C	0	NELFCD	3	affinity chromatography technology	Ayguen O (2008)	1
COX6B1	0	COX5A	0	biochemical	Wan C (2015)	1
NTRK1	1	NELFB	7	affinity chromatography technology	Emdal KB (2015)	1
COX4I1	4	COX5A	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
AR	3	NELFCD	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Yang Y (2010), Yang Y (2010), Yang Y (2010), Yang Y (2010)	4
NTRK1	1	UBE3A	4	affinity chromatography technology	Emdal KB (2015)	1
NCBP1	7	NELFB	7	affinity chromatography technology	Hein MY (2015)	1
NELFCD	3	DNAJA1	2	two hybrid	Stelzl U (2005)	1
TP53	0	UBE3A	4	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study	Nuber U (1998), Huibregtse JM (1993), Yang Y (2007), Kim HC (2009), Scheffner M (1994), Mishra A (2012), Burch L (2004), Ro HS (2006), Nakagawa S (2000), Nakagawa S (2000), Nakagawa S (2000), Huibregtse JM (1991), Honda R (1997), Huibregtse JM (1995), Martinez-Zapien D (2016), Martinez-Zapien D (2016), Rolfe M (1995)	17
HYPK	2	TP53	0	affinity chromatography technology	Choudhury KR (2012)	1
NELFCD	3	COX6C	1	affinity chromatography technology	Ewing RM (2007)	1
NELFB	7	ATP1A1	9	affinity chromatography technology	Mak AB (2010)	1
AR	3	COX5B	0	two hybrid, pull down	Beauchemin AM (2001), Beauchemin AM (2001)	2
NELFCD	3	COX5A	0	affinity chromatography technology	Ewing RM (2007)	1
NELFCD	3	UBE3A	4	pull down, affinity chromatography technology, enzymatic study, two hybrid	Yang Y (2007), Yang Y (2007), Yang Y (2007), Wang J (2011)	4
NCBP1	7	NELFE	0	affinity chromatography technology	Hein MY (2015)	1
HDAC11	0	DNAJA1	2	affinity chromatography technology	Joshi P (2013)	1
COX6B1	0	COX6C	1	affinity chromatography technology	Floyd BJ (2016)	1
NTRK1	1	NELFCD	3	affinity chromatography technology	Emdal KB (2015)	1
NELFCD	3	COX6B1	0	affinity chromatography technology	Ewing RM (2007)	1
NELFCD	3	PHB2	1	affinity chromatography technology	Ewing RM (2007)	1
NTRK1	1	EIF4G1	9	affinity chromatography technology	Emdal KB (2015)	1
NELFCD	3	RPS11	0	affinity chromatography technology	Ewing RM (2007)	1
TP53	0	DNAJA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014), Parrales A (2016), Parrales A (2016)	4
NTRK1	1	MTA1	3	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	PRMT5	3	affinity chromatography technology	Horikawa I (2014)	1
NTRK1	1	MCM7	5	affinity chromatography technology	Emdal KB (2015)	1
NELFCD	3	CCAR2	9	affinity chromatography technology	Ewing RM (2007)	1
NELFCD	3	EPRS	2	two hybrid	Stelzl U (2005)	1
NELFCD	3	RPS14	0	affinity chromatography technology	Ewing RM (2007)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
RPS14	0	RPS26	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
FECH	1	NELFCD	3	affinity chromatography technology	Huttlin EL (2017)	1
COX5A	0	COX5B	0	biochemical	Havugimana PC (2012)	1
NELFCD	3	EIF4G1	9	affinity chromatography technology	Ewing RM (2007)	1
UBE3A	4	AR	3	affinity chromatography technology, enzymatic study	Khan OY (2006), McClurg UL (2016)	2
COX2	0	COX4I1	4	biochemical	Wan C (2015)	1
NTRK1	1	NELFE	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	VIM	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	NELFA	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CCAR2	9	affinity chromatography technology	Emdal KB (2015)	1
RPS26	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Cui D (2013), Fogeron ML (2013)	2
ARAF	0	DNAJA1	2	affinity chromatography technology	So J (2015)	1
NELFA	2	NELFB	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Narita T (2003), Mak AB (2010), Hein MY (2015), Huttlin EL (2017)	4
POLR2C	0	NELFA	2	affinity chromatography technology, affinity chromatography technology	Ayguen O (2008), Hein MY (2015)	2
POLR2C	0	NELFE	0	affinity chromatography technology	Ayguen O (2008)	1
NELFCD	3	COPB2	3	affinity chromatography technology	Ewing RM (2007)	1
NELFCD	3	DNPEP	2	affinity chromatography technology	Ewing RM (2007)	1
NELFCD	3	ATP1A1	9	affinity chromatography technology	Mak AB (2010)	1
CACNA1A	21	NELFCD	3	two hybrid	Kahle JJ (2011)	1
NTRK1	1	DNAJA1	2	affinity chromatography technology	Emdal KB (2015)	1
NELFCD	3	ZNF638	8	two hybrid	Wang J (2011)	1
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
NELFCD	3	HDAC11	0	two hybrid	Stelzl U (2005)	1