PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDE6D	0	RAP2B	0	two hybrid	Nancy V (2002)	1
CDC42	3	RAP1A	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
DNAJC11	2	PDE6D	0	affinity chromatography technology	Huttlin EL (2017)	1
PTGIR	3	PDE6D	0	two hybrid, affinity chromatography technology	Wilson SJ (2006), Wilson SJ (2006)	2
INPP5E	1	RPGR	0	affinity chromatography technology	Boldt K (2016)	1
CETN3	0	PDE6D	0	two hybrid	Stelzl U (2005)	1
RHEB	2	RAP1A	1	affinity chromatography technology	Long X (2005)	1
PDE6D	0	HRAS	2	two hybrid, two hybrid	Hanzal-Bayer M (2002), Nancy V (2002)	2
PDE6D	0	RHOA	0	two hybrid	Nancy V (2002)	1
RHEB	2	HRAS	2	affinity chromatography technology	Long X (2005)	1
PDE6D	0	RAD23A	1	two hybrid	Rual JF (2005)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
RPGR	0	PDE6D	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Linari M (1999), Linari M (1999), Huttlin EL (2017), Boldt K (2016)	4
ARL15	0	PDE6D	0	two hybrid	Stelzl U (2005)	1
INPP5E	1	PDE6D	0	affinity chromatography technology	Boldt K (2016)	1
COPS5	0	PDE6D	0	affinity chromatography technology	Bennett EJ (2010)	1
RAB13	0	PDE6D	0	two hybrid	Marzesco AM (1998)	1
PDE6D	0	RHEB	2	two hybrid	Hanzal-Bayer M (2002)	1
ARL2	0	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
C6orf141	1	PDE6D	0	affinity chromatography technology	Huttlin EL (2017)	1
PDE6D	0	RND1	0	two hybrid, two hybrid	Nancy V (2002), Hanzal-Bayer M (2002)	2
PDE6D	0	RHOB	0	two hybrid	Nancy V (2002)	1
ARL2	0	PDE6D	0	two hybrid, x-ray crystallography, two hybrid, two hybrid	Rual JF (2005), Hanzal-Bayer M (2002), Rolland T (2014), Yu H (2011)	4
CUL1	7	PDE6D	0	affinity chromatography technology	Bennett EJ (2010)	1
RAB28	0	PDE6D	0	affinity chromatography technology	Boldt K (2016)	1
CDC42	3	PDE6D	0	two hybrid	Stelzl U (2005)	1
ARL3	1	PDE6D	0	two hybrid	Stelzl U (2005)	1
PDE6D	0	RAP1A	1	two hybrid, two hybrid	Nancy V (2002), Hanzal-Bayer M (2002)	2
RAB18	1	PDE6D	0	two hybrid	Stelzl U (2005)	1
TALDO1	2	PDE6D	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDE6D	0	ARL16	2	two hybrid	Rolland T (2014)	1
RPGR	0	RHOA	0	bioid	Gupta GD (2015)	1
FAM219A	1	PDE6D	0	two hybrid	Stelzl U (2005)	1