PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPKAPK2	1	UBE2J1	1	enzymatic study	Menon MB (2013)	1
DERL2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012)	3
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
DERL2	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	7
DIO2	0	UBE2J1	1	pull down	Kim BW (2003)	1
ELAVL1	0	TCTN2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBA1	1	UBE2J1	1	pull down	Jin J (2007)	1
TRIM63	0	YOD1	0	enzymatic study	Loch CM (2012)	1
ELAVL1	0	DIO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
YOD1	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Ernst R (2009), Locke M (2014), Locke M (2014), Ernst R (2009), Ernst R (2009), Schimmack G (2017), Schimmack G (2017)	7
TCTN3	2	AUP1	0	bioid	Gupta GD (2015)	1
RNF5	0	UBE2J1	1	affinity chromatography technology, affinity chromatography technology	Younger JM (2006), Grove DE (2011)	2
UBE2J1	1	LRSAM1	2	two hybrid	van Wijk SJ (2009)	1
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
YOD1	0	DERL1	2	affinity chromatography technology	Ernst R (2009)	1
SEL1L	2	FAF2	4	affinity chromatography technology, affinity chromatography technology	Mueller B (2008), Christianson JC (2012)	2
UBE2J1	1	PJA2	4	two hybrid	van Wijk SJ (2009)	1
AQP2	0	UBE2J1	1	two hybrid	Trimpert C (2017)	1
VCP	6	RNF2	1	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Cao Q (2014)	2
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
VCP	6	HLA-A	0	affinity chromatography technology	Soetandyo N (2010)	1
RNF185	1	UBE2J1	1	affinity chromatography technology	El Khouri E (2013)	1
AUP1	0	SEL1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Mueller B (2008), Christianson JC (2012), Christianson JC (2012)	5
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
DERL2	0	SEL1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Lilley BN (2005), Huang CH (2013), Huang CH (2013), Huang CH (2013), Christianson JC (2012)	6
ELAVL1	0	UBE2J1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF2	1	FAF2	4	affinity chromatography technology	Cao Q (2014)	1
UBE2J1	1	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
AUP1	0	OS9	4	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
ERLEC1	1	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012)	4
UBE2J1	1	283458	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
OS9	4	VCP	6	affinity chromatography technology	Tyler RE (2012)	1
ELAVL1	0	MAPKAPK2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EVC2	5	UBE2J1	1	bioid	Gupta GD (2015)	1
RNF5	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Younger JM (2006), Grove DE (2011), El Khouri E (2013)	3
YOD1	0	FAF2	4	affinity chromatography technology	Ernst R (2009)	1
DIO2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Arrojo E Drigo R (2013), Arrojo E Drigo R (2013)	2
UBE2J1	1	TRIM63	0	two hybrid	van Wijk SJ (2009)	1
AUP1	0	UBE2J1	1	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Claessen JH (2010)	2
CREB3	1	UBE2J1	1	two hybrid	Yu H (2011)	1
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
AUP1	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
UBE2J1	1	ASNA1	2	affinity chromatography technology	Claessen JH (2010)	1
FAF2	4	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
ERLEC1	1	DERL2	0	affinity chromatography technology	Christianson JC (2012)	1
UBE2J1	1	GHITM	1	affinity chromatography technology	Huttlin EL (2015)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
OS9	4	DERL2	0	affinity chromatography technology, affinity chromatography technology	Tyler RE (2012), Huang CH (2013)	2
ST3GAL1	1	UBE2J1	1	affinity chromatography technology	Huttlin EL (2017)	1
TCTN2	2	AUP1	0	bioid	Gupta GD (2015)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
TCTN3	2	DERL2	0	bioid	Gupta GD (2015)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
TMEM17	0	HLA-A	0	bioid	Gupta GD (2015)	1
UBE2J1	1	DERL1	2	affinity chromatography technology	Claessen JH (2010)	1
SEL1L	2	DERL1	2	affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013)	2
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
SEL1L	2	ERLEC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Christianson JC (2008), Christianson JC (2008), Fujimori T (2013), Fujimori T (2013), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012)	8
UBE2J1	1	SYVN1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Wijk SJ (2009), Christianson JC (2012), Christianson JC (2012), Schulz J (2017)	4
PRKN	1	UBE2J1	1	affinity chromatography technology, pull down, pull down, pull down, pull down	Imai Y (2001), Kalia SK (2004), Imai Y (2002), Fallon L (2006), Kazlauskaite A (2014)	5
UBE2J1	1	VCP	6	affinity chromatography technology	Claessen JH (2010)	1
TCTN3	2	UBE2J1	1	bioid	Gupta GD (2015)	1
FAF2	4	OS9	4	affinity chromatography technology	Christianson JC (2012)	1
UBE2J1	1	DERL3	0	affinity chromatography technology	Claessen JH (2010)	1
DERL1	2	HLA-A	0	affinity chromatography technology, affinity chromatography technology	Lilley BN (2004), Burr ML (2011)	2
OS9	4	SEL1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hosokawa N (2008), Mueller B (2008), Christianson JC (2008), Christianson JC (2008), Christianson JC (2008), Hosokawa N (2009), Hosokawa N (2009), Tyler RE (2012), Tyler RE (2012), Huang CH (2013), Fujimori T (2013), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Dersh D (2014), Schulz J (2017)	17
UBE2J1	1	BRCA1	7	two hybrid	van Wijk SJ (2009)	1
HLA-A	0	UBE2J1	1	affinity chromatography technology	Burr ML (2011)	1
UBE2J1	1	FAF2	4	affinity chromatography technology	Claessen JH (2010)	1
AUP1	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Christianson JC (2012), Christianson JC (2012)	4
TMEM17	0	UBE2J1	1	bioid	Gupta GD (2015)	1
SEL1L	2	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Wu ZZ (2011), Hosokawa N (2008), Mueller B (2008), Christianson JC (2008), Huang CH (2013), Huang CH (2013), Huang CH (2013), Huang CH (2013), Fujimori T (2013), Iida Y (2011), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), van de Weijer ML (2014), Zhang T (2015), Hosokawa N (2016), Hosokawa N (2016), Hosokawa N (2016), Schulz J (2017), Schulz J (2017)	22
HLA-A	0	SYVN1	2	affinity chromatography technology	Burr ML (2011)	1
SYVN1	2	FAF2	4	affinity chromatography technology	Zhang T (2015)	1
SEL1L	2	UBE2J1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mueller B (2008), Christianson JC (2012), Christianson JC (2012), Schulz J (2017)	4
ELAVL1	0	YOD1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
UBE2J1	1	DERL2	0	affinity chromatography technology	Claessen JH (2010)	1
ELAVL1	0	PJA2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
OS9	4	UBE2J1	1	affinity chromatography technology	Tyler RE (2012)	1
TMEM216	0	UBE2J1	1	bioid	Gupta GD (2015)	1
UBE2J1	1	BIRC2	1	two hybrid, pull down, affinity chromatography technology	van Wijk SJ (2009), Wu CJ (2005), Elangovan M (2017)	3
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
TCTN2	2	FAF2	4	bioid	Gupta GD (2015)	1
UBE2J1	1	YOD1	0	affinity chromatography technology	Claessen JH (2010)	1
ERLEC1	1	UBE2J1	1	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012)	2
TCTN3	2	DERL1	2	bioid	Gupta GD (2015)	1
ERLEC1	1	OS9	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yanagisawa K (2010), Yanagisawa K (2010), Christianson JC (2012)	3
TMEM216	0	AUP1	0	bioid	Gupta GD (2015)	1
UBE2J1	1	RNF2	1	two hybrid	van Wijk SJ (2009)	1
YOD1	0	SYVN1	2	affinity chromatography technology	Bernardi KM (2013)	1
AUP1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Raman M (2015)	3
TCTN2	2	HLA-A	0	affinity chromatography technology	Huttlin EL (2017)	1
OS9	4	CREB3	1	two hybrid	Eleveld-Trancikova D (2010)	1
UBE2J1	1	TRIM27	2	two hybrid	Markson G (2009)	1
ELAVL1	0	TMEM216	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TCTN2	2	UBE2J1	1	bioid	Gupta GD (2015)	1
OS9	4	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Tyler RE (2012), Tyler RE (2012), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Schulz J (2017)	8
DERL2	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Bernardi KM (2010), Huang CH (2013), Huang CH (2013), Huang CH (2013), Zhang T (2015)	6
TMEM17	0	AUP1	0	bioid	Gupta GD (2015)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1
RNF185	1	DERL1	2	affinity chromatography technology	El Khouri E (2013)	1