Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PDE4D 5144 THEOPHYLLINE CHEMBL190 inhibitor ChemblInteractions
PDE4D 5144 ADENOSINE PHOSPHATE CHEMBL752 product of DrugBank 17088426
PDE4D 5144 ISOBUTYLMETHYLXANTHINE CHEMBL275084 DrugBank 10592235
PDE4D 5144 PENTOXIFYLLINE CHEMBL628 inhibitor ChemblInteractions
PDE4D 5144 OXTRIPHYLLINE CHEMBL1200434 inhibitor ChemblInteractions, TTD
PDE4D 5144 ETAZOLATE CHEMBL356388 TdgClinicalTrial
PDE4D 5144 ROFLUMILAST CHEMBL193240 inhibitor ChemblInteractions, DrugBank 17726343, 10592235
PDE4D 5144 PICLAMILAST CHEMBL42126 DrugBank 15765929, 10592235
PDE4D 5144 CHEMBL63859 CHEMBL63859 DrugBank 17139284, 17016423, 10592235
PDE4D 5144 ZARDAVERINE CHEMBL313842 DrugBank 10592235
PDE4D 5144 CILOMILAST CHEMBL511115 inhibitor DrugBank 17155857, 10592235
PDE4D 5144 CHEMBL506972 CHEMBL506972 DrugBank 10592235
PDE4D 5144 CHEMBL1229585 CHEMBL1229585 DrugBank 10592235
PDE4D 5144 CHEMBL1232082 CHEMBL1232082 inhibitor GuideToPharmacologyInteractions
PDE4D 5144 THEOPHYLLINE SODIUM GLYCINATE CHEMBL1200578 inhibitor ChemblInteractions
PDE4D 5144 FLAVOXATE HYDROCHLORIDE CHEMBL1200875 inhibitor ChemblInteractions
PDE4D 5144 AMINOPHYLLINE CHEMBL1370561 inhibitor ChemblInteractions
PDE4D 5144 DYPHYLLINE CHEMBL1752 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 7925603, 17139284, 17016423
PDE4D 5144 (-)-ROLIPRAM CHEMBL430893 DrugBank
PDE4D 5144 CRISABOROLE CHEMBL484785 inhibitor ChemblInteractions, DrugBank
PDE4D 5144 CHEMBL74078 CHEMBL74078 DrugBank 10592235
PDE4D 5144 CDP840 CHEMBL32442 inhibitor GuideToPharmacologyInteractions
PDE4D 5144 SODIUM PHENYLBUTYRATE CHEMBL1746 inhibitor GuideToPharmacologyInteractions
PDE4D 5144 DIPYRIDAMOLE CHEMBL932 inhibitor ChemblInteractions
PDE4D 5144 ROLIPRAM CHEMBL63 inhibitor GuideToPharmacologyInteractions, DrugBank 17139284, 17016423, 10592235
PDE4D 5144 TETOMILAST CHEMBL332750 DrugBank
PDE4D 5144 PROPOXYPHENE CHEMBL1213351 inhibitor GuideToPharmacologyInteractions
PDE4D 5144 RESVERATROL CHEMBL165 TdgClinicalTrial
PDE4D 5144 AMLEXANOX CHEMBL1096 inhibitor ChemblInteractions
PDE4D 5144 APREMILAST CHEMBL514800 antagonist, inhibitor GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 25864487, 17352685
PDE4D 5144 IBUDILAST CHEMBL19449 inhibitor DrugBank 16313925
PDE4D 5144 ILOPROST CHEMBL494 inducer DrugBank 2461561, 12441759, 11551870, 12952271

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PDE4D rs17742120 G quetiapine efficacy yes The number of G alleles present in a patient was negatively associated with PGI score. Please note that this variant is in high linkage disequilibrium with rs17382202 and rs2164660. Allele G is associated with increased response to quetiapine in people with Schizophrenia as compared to allele A. 23241943 1450815058
PDE4D rs2164660 A quetiapine efficacy yes The number of A alleles present in a patient was negatively associated with PGI score. Please note that this variant is in high linkage disequilibrium with rs17742120 and rs17382202. Allele A is associated with increased response to quetiapine in people with Schizophrenia as compared to allele G. 23241943 1450815067
PDE4D rs17382202 T quetiapine efficacy yes The number of T alleles present in a patient was negatively associated with PGI score. Please note that this variant is in high linkage disequilibrium with rs17742120 and rs2164660. Allele T is associated with increased response to quetiapine in people with Schizophrenia as compared to allele C. 23241943 1450815045