Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PDE4B 5142 THEOPHYLLINE CHEMBL190 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 15639300
PDE4B 5142 ENPROFYLLINE CHEMBL279898 inhibitor TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
PDE4B 5142 FILAMINAST CHEMBL590754 DrugBank 17139284, 17016423, 10592235
PDE4B 5142 (-)-ROLIPRAM CHEMBL430893 inhibitor DrugBank 11752352, 17139284, 17016423
PDE4B 5142 CHEMBL521203 CHEMBL521203 DrugBank 10592235
PDE4B 5142 CHEMBL74078 CHEMBL74078 DrugBank 10592235
PDE4B 5142 CDP840 CHEMBL32442 inhibitor GuideToPharmacologyInteractions
PDE4B 5142 RESVERATROL CHEMBL165 TdgClinicalTrial
PDE4B 5142 AMLEXANOX CHEMBL1096 inhibitor ChemblInteractions
PDE4B 5142 DYPHYLLINE CHEMBL1752 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 7925603, 17139284, 17016423, 225216
PDE4B 5142 PENTOXIFYLLINE CHEMBL628 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17139284, 17016423
PDE4B 5142 PAPAVERINE CHEMBL19224 inhibitor TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 19231363, 12646997
PDE4B 5142 CHEMBL519827 CHEMBL519827 DrugBank 17139284, 17016423, 10592235
PDE4B 5142 PROPOXYPHENE CHEMBL1213351 inhibitor GuideToPharmacologyInteractions
PDE4B 5142 DIPYRIDAMOLE CHEMBL932 inhibitor ChemblInteractions
PDE4B 5142 THEOPHYLLINE SODIUM GLYCINATE CHEMBL1200578 inhibitor ChemblInteractions
PDE4B 5142 FLAVOXATE HYDROCHLORIDE CHEMBL1200875 inhibitor ChemblInteractions
PDE4B 5142 OXTRIPHYLLINE CHEMBL1200434 inhibitor ChemblInteractions
PDE4B 5142 ETAZOLATE CHEMBL356388 TdgClinicalTrial
PDE4B 5142 ADENOSINE PHOSPHATE CHEMBL752 product of DrugBank 16843095, 17088426, 17333137
PDE4B 5142 THEOBROMINE CHEMBL1114 inhibitor DrugBank 11692087, 15095008, 17514358, 18568240
PDE4B 5142 INAMRINONE CHEMBL12856 inhibitor TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
PDE4B 5142 PICLAMILAST CHEMBL42126 DrugBank 15765929, 10592235
PDE4B 5142 ROLIPRAM CHEMBL63 inhibitor GuideToPharmacologyInteractions, DrugBank 17139284, 17016423, 10592235
PDE4B 5142 CRISABOROLE CHEMBL484785 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank
PDE4B 5142 SODIUM PHENYLBUTYRATE CHEMBL1746 inhibitor GuideToPharmacologyInteractions
PDE4B 5142 CHEMBL1232082 CHEMBL1232082 inhibitor GuideToPharmacologyInteractions
PDE4B 5142 AMINOPHYLLINE CHEMBL1370561 inhibitor ChemblInteractions
PDE4B 5142 [R]-Mesopram CHEMBL603830 DrugBank 17139284, 17016423, 10592235
PDE4B 5142 CHEMBL1230617 CHEMBL1230617 DrugBank 17139284, 17016423
PDE4B 5142 CAFFEINE CHEMBL113 TdgClinicalTrial, TEND
PDE4B 5142 CILOMILAST CHEMBL511115 inhibitor DrugBank 17155857
PDE4B 5142 APREMILAST CHEMBL514800 antagonist, inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 25864487, 17352685
PDE4B 5142 IBUDILAST CHEMBL19449 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 16313925
PDE4B 5142 ILOPROST CHEMBL494 inducer DrugBank 2461561, 12441759, 11551870, 12952271
PDE4B 5142 ROFLUMILAST CHEMBL193240 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 17726343

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PDE4B rs12046844 A gemcitabine "efficacy","toxicity" no SNPs were selected based on prior literature and no alleles demonstrated any association with neurotoxicity or overall survival. Allele A is not associated with response to gemcitabine and paclitaxel in women with Breast Neoplasms as compared to allele G. 24361227 1184086254