PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCDC102B	0	CCDC33	3	two hybrid	Rolland T (2014)	1
TFG	3	SPG21	0	two hybrid	Rolland T (2014)	1
LMNA	2	AGTRAP	1	two hybrid	Dittmer TA (2014)	1
MOV10	6	TCF12	14	affinity chromatography technology	Castello A (2012)	1
ZNF263	2	SPG21	0	two hybrid	Rual JF (2005)	1
TRAF2	1	SPG21	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DHX40	3	SPG21	0	biochemical	Havugimana PC (2012)	1
KRT15	2	SPG21	0	two hybrid	Rolland T (2014)	1
LMNA	2	REEP6	0	two hybrid	Dittmer TA (2014)	1
TRIM23	3	TRAF1	0	two hybrid	Rolland T (2014)	1
ARL6IP1	0	RTN4	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
GGA2	2	SPG21	0	two hybrid	Rual JF (2005)	1
CRYAA	0	SPG21	0	two hybrid	Rolland T (2014)	1
LMNA	2	ARL6IP1	0	two hybrid	Dittmer TA (2014)	1
LMNA	2	RABAC1	0	two hybrid	Dittmer TA (2014)	1
SPG21	0	AGTRAP	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LMNA	2	SPG21	0	two hybrid	Dittmer TA (2014)	1
TRAF1	0	SPG21	0	two hybrid	Rolland T (2014)	1
RTN4	4	RABAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
SPG21	0	RTN4	4	two hybrid	Rual JF (2005)	1
IKZF3	1	SPG21	0	two hybrid	Rolland T (2014)	1
MID2	1	TRIM54	1	two hybrid	Rolland T (2014)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TCF12	14	SPG21	0	two hybrid	Rolland T (2014)	1
SPG21	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SPG21	0	CMTM5	0	two hybrid	Rolland T (2014)	1
SPG21	0	CCDC33	3	two hybrid	Rolland T (2014)	1
TRIM23	3	GGA2	2	two hybrid	Rual JF (2005)	1
SPG21	0	DTX3L	1	two hybrid	Rolland T (2014)	1
SPG21	0	INCA1	1	two hybrid	Rolland T (2014)	1
SPG21	0	TRIM54	1	two hybrid	Rolland T (2014)	1
MID2	1	SPG21	0	two hybrid	Rolland T (2014)	1
TRAF2	1	CCDC33	3	two hybrid	Rual JF (2005)	1
MOV10	6	SPG21	0	affinity chromatography technology	Castello A (2012)	1
SPG21	0	SPRED2	12	two hybrid	Rolland T (2014)	1
LMNA	2	RTN4	4	two hybrid	Dittmer TA (2014)	1
HMGCS1	0	SPG21	0	biochemical	Havugimana PC (2012)	1
S100B	0	SPG21	0	two hybrid	Rolland T (2014)	1
SPG21	0	FAM114A1	0	two hybrid	Rolland T (2014)	1
SPG21	0	EFHC2	0	two hybrid	Rolland T (2014)	1
SPG21	0	TRIM9	3	two hybrid	Rolland T (2014)	1
LMNA	2	CMTM5	0	two hybrid	Dittmer TA (2014)	1
TRIM23	3	ATPAF2	1	two hybrid	Rolland T (2014)	1
GSK3A	1	SPG21	0	two hybrid	Pilot-Storck F (2010)	1
SPG21	0	MTMR9	1	two hybrid	Rual JF (2005)	1
PRPS1	0	SPG21	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ARL6IP1	0	SPG21	0	two hybrid	Rolland T (2014)	1
IKZF3	1	ATPAF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SPG21	0	ATPAF2	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
SPG21	0	YLPM1	6	biochemical	Havugimana PC (2012)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
RABAC1	0	SPG21	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CUTC	0	SPG21	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM54	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
SPG21	0	REEP6	0	two hybrid	Rolland T (2014)	1
SPG21	0	AKIRIN2	1	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
DTX3L	1	TRIM9	3	two hybrid	Woodsmith J (2012)	1
TRIM23	3	SPG21	0	two hybrid	Rolland T (2014)	1
MOV10	6	LMNA	2	affinity chromatography technology	Castello A (2012)	1
CD4	1	SPG21	0	affinity chromatography technology, two hybrid	Zeitlmann L (2001), Zeitlmann L (2001)	2
SPG21	0	CTPS2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM54	1	DTX2	3	two hybrid	Rolland T (2014)	1
TCF4	26	SPG21	0	two hybrid	Rolland T (2014)	1
SPG21	0	CCDC102B	0	two hybrid	Rolland T (2014)	1
AGTRAP	1	FAM114A1	0	two hybrid	Rolland T (2014)	1
FAM114A1	0	CMTM5	0	two hybrid	Rolland T (2014)	1