Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
NT5C3A	rs3750117	AA	gemcitabine	"other","metabolism/PK"	yes	AA vs AG vs GG. Also, significantly increased elimination clearance of dFdU was seen in patients with the GG genotype vs AA+AG p=0.037. dFdU = 2',2'-difluorodeoxyuridine (gemcitabine is inactivated to this less potent metabolite). Association with clinical outcomes was not reported.	Genotype AA is associated with increased clearance of gemcitabine in people with Neoplasms as compared to genotype GG.	22838949	978639890
NT5C3A	rs6946062	TT	gemcitabine	metabolism/PK	no	Gemcitabine, dFdCTP, and dFdU plasma concentrations were measured before (5, 15, 30, 45 min) and after gemcitabine infusion (1, 1.25, 1.5, 2, 6, 24, 48, 72 hrs). Population pharmacokinetic analysis of gemcitabine and metabolites (dFdU, dFdCTP) were performed by non-linear mixed effects modeling. rs6946062 is not associated with metabolism of gemcitabine.	Genotype TT is not associated with metabolism of gemcitabine as compared to genotypes CC + CT.	24300978	1184174889