PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AB1	2	HGH1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
AES	2	HGH1	0	biochemical	Kristensen AR (2012)	1
HSP90AB1	2	TTC4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
HGH1	0	SLK	2	biochemical	Kristensen AR (2012)	1
EGLN3	0	FBXL12	1	affinity chromatography technology	Rodriguez J (2016)	1
HGH1	0	HGS	5	biochemical	Kristensen AR (2012)	1
HGH1	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
EGLN3	0	TTC4	1	affinity chromatography technology	Rodriguez J (2016)	1
HGH1	0	POLA2	2	two hybrid	Stelzl U (2005)	1
EGLN3	0	HGH1	0	affinity chromatography technology	Rodriguez J (2016)	1
HGH1	0	RPA1	0	two hybrid	Stelzl U (2005)	1
ATG2A	8	HGH1	0	affinity chromatography technology	Behrends C (2010)	1
TES	1	HSP90AB1	2	affinity chromatography technology	Sala S (2017)	1
FKBP5	0	TTC4	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HGH1	0	GTF3C1	11	two hybrid	Stelzl U (2005)	1
FKBP5	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
AES	2	HGS	5	biochemical	Kristensen AR (2012)	1
FBXL12	1	HGH1	0	affinity chromatography technology	Nishiyama M (2015)	1
HGH1	0	APOM	0	two hybrid	Stelzl U (2005)	1
AES	2	MED31	0	two hybrid	Stelzl U (2005)	1
TES	1	HGH1	0	affinity chromatography technology	Sala S (2017)	1
HGH1	0	PTN	0	two hybrid	Stelzl U (2005)	1
EGLN3	0	GTF3C1	11	affinity chromatography technology	Rodriguez J (2016)	1
HGH1	0	TRIT1	0	two hybrid	Stelzl U (2005)	1
TTC4	1	HGS	5	biochemical	Kristensen AR (2012)	1
HGH1	0	MED31	0	two hybrid	Stelzl U (2005)	1
TRIM14	1	RPA1	0	bioid	Tan P (2017)	1
SLK	2	HGS	5	biochemical	Kristensen AR (2012)	1
FKBP5	0	HGH1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HGH1	0	TMEM256	0	two hybrid	Stelzl U (2005)	1
TRIM14	1	HGH1	0	bioid	Tan P (2017)	1
TTC4	1	SLK	2	biochemical	Kristensen AR (2012)	1
HGH1	0	TTC4	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Huttlin EL (2017)	5