PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCK2	2	EIF3H	3	two hybrid	Rolland T (2014)	1
GRB2	2	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
NCK2	2	PAK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Braverman LE (1999), Cowan CA (2001), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
NCK2	2	WASF2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	ABI3BP	11	two hybrid	Bandyopadhyay S (2010)	1
WAS	0	ABI3	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KRT15	2	KLC3	3	two hybrid	Rolland T (2014)	1
DTNB	1	DTNBP1	1	two hybrid	Rolland T (2014)	1
ABI3	1	DTNBP1	1	two hybrid	Rual JF (2005)	1
HOMER3	0	ABI3	1	two hybrid	Venkatesan K (2009)	1
ABI3	1	ABI3BP	11	two hybrid	Matsuda S (2001)	1
HOMER1	1	ABI3	1	two hybrid	Rual JF (2005)	1
WAS	0	VASP	0	pull down	Castellano F (2001)	1
MAGEA12	0	ABI3	1	two hybrid	Rolland T (2014)	1
KRT15	2	ABI3	1	two hybrid	Rual JF (2005)	1
ENAH	0	EVL	4	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
EIF3H	3	ABI3	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
KLC3	3	KLC4	2	affinity chromatography technology	Hein MY (2015)	1
ABI3	1	PAK1	2	pull down	Ichigotani Y (2002)	1
WAS	0	NCK2	2	affinity chromatography technology, two hybrid	Buvall L (2013), Rolland T (2014)	2
KRT13	2	KLC3	3	two hybrid	Rolland T (2014)	1
RUNX1T1	1	645455	0	two hybrid	Rual JF (2005)	1
VASP	0	ENAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
KRT13	2	KLC4	2	two hybrid	Rolland T (2014)	1
PSMA1	1	ABI3	1	two hybrid	Rolland T (2014)	1
GRB2	2	VASP	0	affinity chromatography technology	Brehme M (2009)	1
NCK2	2	PAK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ABI3	1	ENAH	0	affinity chromatography technology, pull down	Hirao N (2006), Hirao N (2006)	2
ABI3	1	EVL	4	two hybrid	Rolland T (2014)	1
GRB2	2	WAS	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Banin S (1996), She HY (1997), She HY (1997), She HY (1997)	4
KIAA0408	0	ABI3	1	two hybrid	Rual JF (2005)	1
RUNX1T1	1	HOMER3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HOMER3	0	HOMER1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
PAK1	2	PAK2	0	affinity chromatography technology	Varjosalo M (2013)	1
ABI3	1	PAK2	0	pull down	Ichigotani Y (2002)	1
VASP	0	ABI3	1	two hybrid	Rolland T (2014)	1
KRT13	2	ABI3	1	two hybrid	Rolland T (2014)	1
ABI3	1	CEP44	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KRT15	2	PSMA1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DTNBP1	1	KIAA0408	0	two hybrid	Camargo LM (2007)	1
FBF1	2	GRB2	2	bioid	Gupta GD (2015)	1
ABI3	1	FBF1	2	two hybrid	Rolland T (2014)	1
NUP58	0	ABI3	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KRT15	2	KIAA0408	0	two hybrid	Rual JF (2005)	1
SNAP23	0	ABI3	1	two hybrid	Rual JF (2005)	1
RUNX1T1	1	ABI3	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DTNB	1	ABI3	1	two hybrid	Rolland T (2014)	1
ABI3	1	ARMC7	1	two hybrid	Rolland T (2014)	1
GRB2	2	ABI3	1	two hybrid	Rolland T (2014)	1
PSMA1	1	MRFAP1L1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ABI3	1	MRFAP1L1	0	two hybrid	Rolland T (2014)	1
KANK2	4	ABI3	1	two hybrid	Rolland T (2014)	1
PSMA1	1	HOMER3	0	two hybrid	Rolland T (2014)	1
CEP44	2	NCK2	2	bioid	Gupta GD (2015)	1
WASF2	0	ABI3	1	affinity chromatography technology, pull down	Hirao N (2006), Hirao N (2006)	2
HOMER3	0	WASF2	0	affinity chromatography technology	Huttlin EL (2017)	1
ACTN3	2	ABI3	1	two hybrid	Rolland T (2014)	1
VASP	0	EVL	4	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
EVL	4	WASF2	0	affinity chromatography technology	Huttlin EL (2017)	1
TMEM147	1	ABI3	1	two hybrid	Rual JF (2005)	1
ABI3	1	KLC4	2	two hybrid	Rolland T (2014)	1
ABI3	1	ABI3	1	two hybrid	Rolland T (2014)	1
ABI3	1	645455	0	two hybrid	Rual JF (2005)	1
CEP44	2	MRFAP1L1	0	two hybrid	Rolland T (2014)	1
ABI3	1	KLC3	3	two hybrid	Rolland T (2014)	1
NCK2	2	ABI3	1	two hybrid	Rolland T (2014)	1
FARSA	6	ABI3	1	two hybrid	Rolland T (2014)	1
KRT15	2	KLC4	2	two hybrid	Rolland T (2014)	1
KRT13	2	FBF1	2	two hybrid	Rolland T (2014)	1