PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
DVL2	5	TRAF2	1	two hybrid	Rual JF (2005)	1
ZNF165	1	ELOA2	0	two hybrid	Rual JF (2005)	1
ZCCHC10	0	CEP70	1	two hybrid	Rolland T (2014)	1
ELOA2	0	CEP70	1	two hybrid	Rual JF (2005)	1
ZBTB43	1	ELOA2	0	two hybrid	Rual JF (2005)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
COIL	1	ZCCHC10	0	two hybrid	Rolland T (2014)	1
ELOA2	0	SOHLH2	0	two hybrid	Rual JF (2005)	1
DVL2	5	ELOA2	0	two hybrid	Rual JF (2005)	1
ELOA2	0	KXD1	1	two hybrid	Rual JF (2005)	1
COIL	1	ELOA2	0	two hybrid	Lim J (2006)	1
ELOA2	0	ZCCHC10	0	two hybrid	Rolland T (2014)	1
CBX5	3	ELOA2	0	two hybrid	Rual JF (2005)	1
ELOA2	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
DVL2	5	ZNF165	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ZNF165	1	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ELOA2	0	ELOB	1	pull down	Aso T (2000)	1
ELOA2	0	ELOC	0	pull down	Aso T (2000)	1
HECW2	13	ELOA2	0	affinity chromatography technology	Lu L (2013)	1
CALCOCO2	0	ELOA2	0	two hybrid	Rual JF (2005)	1
CDK6	0	ELOA2	0	enzymatic study	Anders L (2011)	1
TRIM37	7	ELOA2	0	two hybrid	Rual JF (2005)	1
TRAF2	1	ELOA2	0	two hybrid	Rual JF (2005)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
COIL	1	CEP70	1	two hybrid	Lim J (2006)	1
CBX5	3	ELOC	0	two hybrid	Wang J (2011)	1
TRAF2	1	ZBTB43	1	two hybrid	Rual JF (2005)	1