PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
HERC5	2	PITX2	1	pull down	Takeuchi T (2006)	1
NTRK1	1	HERC5	2	affinity chromatography technology	Emdal KB (2015)	1
SNCA	0	HSPA8	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	Redeker V (2012), Pemberton S (2011), Choi HS (2012), Choi HS (2012), Woods WS (2007), Choi HS (2012)	6
HERC5	2	HERC5	2	enzymatic study	Kroismayr R (2004)	1
ZC3H3	4	HERC5	2	affinity chromatography technology	Huttlin EL (2015)	1
RPL18	0	RRP8	6	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	ISG15	0	affinity chromatography technology	Lee JH (2010)	1
DGCR8	4	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	RPS2	3	affinity chromatography technology	Zanon A (2013)	1
ISG15	0	UBE2L6	0	affinity chromatography technology	Zhao C (2005)	1
SIRT7	1	HERC5	2	affinity chromatography technology, affinity chromatography technology	Tsai YC (2012), Jiang L (2017)	2
HSPA8	4	CCND1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Truman AW (2012)	3
NTRK1	1	TTK	4	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	GPATCH4	1	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	NME2	0	affinity chromatography technology	Okatsu K (2012)	1
RPL14	2	RPL18	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NTRK1	1	RPS2	3	affinity chromatography technology	Emdal KB (2015)	1
HERC5	2	TXNRD1	2	affinity chromatography technology	Wong JJ (2006)	1
CCNB1	3	CDKN1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amador V (2007), Garcia-Wilson E (2005), Ando T (2001), Poon RY (1996), Fogeron ML (2013), Chen TC (2014)	6
CTNNB1	30	FOXM1	3	affinity chromatography technology	Chen Y (2016)	1
FOXL1	0	HERC5	2	affinity chromatography technology	Li X (2015)	1
NOP16	2	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
HBP1	1	RPL18	0	affinity chromatography technology	Lampert F (2018)	1
GPATCH4	1	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
GPATCH4	1	RRP8	6	affinity chromatography technology	Huttlin EL (2017)	1
HASPIN	1	HERC5	2	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	RPL14	2	affinity chromatography technology	Emdal KB (2015)	1
DGCR8	4	RRP8	6	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	BECN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Choubey V (2014), Lonskaya I (2014), Lonskaya I (2014), Lonskaya I (2014)	4
CCNB1	3	STK38	0	affinity chromatography technology	Lin Z (2015)	1
HERC5	2	UBE2L6	0	pull down	Shi HX (2010)	1
TXNRD1	2	TP53	0	affinity chromatography technology	Seemann S (2005)	1
SMAD4	9	IRF3	4	affinity chromatography technology	Qing J (2004)	1
SNCA	0	HERC5	2	affinity chromatography technology	Hein MY (2015)	1
RPL18	0	RPS2	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PRKN	1	HERC5	2	affinity chromatography technology, affinity chromatography technology	Im E (2016), Im E (2016)	2
BECN1	2	TP53	0	affinity chromatography technology	Verma N (2017)	1
ISG15	0	HNRNPU	12	affinity chromatography technology	Zhao C (2005)	1
CCNE1	1	HERC5	2	affinity chromatography technology, pull down	Mitsui K (1999), Mitsui K (1999)	2
NTRK1	1	RANBP1	0	affinity chromatography technology	Emdal KB (2015)	1
CDKN1A	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
RAN	1	HERC5	2	affinity chromatography technology	Woods MW (2014)	1
NTRK1	1	CTNNB1	30	affinity chromatography technology	Emdal KB (2015)	1
ZNF2	1	RRP8	6	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	McKenzie PP (2003), McKenzie PP (2003), Jeon Y (2007), Derjuga A (2001), Datta NS (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bresnahan WA (1996), Bendjennat M (2003), Bao GC (2006), Chen J (1996), Chen J (1996), Chen J (1996), Levkau B (1998), Poon RY (1996), Zhao J (1998), Wang J (2011), Fogeron ML (2013), Chen TC (2014)	20
TP53	0	CCND1	1	affinity chromatography technology	Yang P (2016)	1
CTNNB1	30	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
RPL10	3	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
HERC5	2	STK38	0	pull down	Takeuchi T (2006)	1
ISG15	0	RAN	1	affinity chromatography technology	Zhao C (2005)	1
RANBP1	0	HERC5	2	affinity chromatography technology	Woods MW (2014)	1
SIRT7	1	TP53	0	affinity chromatography technology	Tsai YC (2012)	1
TP53	0	RPL18	0	affinity chromatography technology	Fogeron ML (2013)	1
HERC5	2	CCND1	1	pull down	Mitsui K (1999)	1
NTRK1	1	HSPA8	4	affinity chromatography technology	Emdal KB (2015)	1
TTK	4	TP53	0	affinity chromatography technology, pull down, enzymatic study	Huang YF (2009), Huang YF (2009), Huang YF (2009)	3
CTNNB1	30	CCNE1	1	pull down, affinity chromatography technology, affinity chromatography technology	Park CS (2004), Park CS (2004), Park CS (2004)	3
NTRK1	1	RAN	1	affinity chromatography technology	Emdal KB (2015)	1
SMAD4	9	HERC5	2	affinity chromatography technology, affinity chromatography technology	Coyle-Rink J (2002), Coyle-Rink J (2002)	2
CTNNB1	30	CCNA2	1	pull down, affinity chromatography technology	Park CS (2004), Park CS (2004)	2
HERC5	2	NME2	0	affinity chromatography technology, two hybrid	Hochrainer K (2008), Hochrainer K (2008)	2
TP53	0	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Akakura S (2001), Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994), Karras GI (2017)	7
CDKN1A	1	RPL18	0	two hybrid	Wang J (2011)	1
CCNA2	1	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Amador V (2007), Wu G (1997), Lin ML (2011), Chen J (1996), Levkau B (1998), Poon RY (1996), Fogeron ML (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
NXF2	0	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
CCNE1	1	FOXM1	3	affinity chromatography technology, enzymatic study	Major ML (2004), Luescher-Firzlaff JM (2006)	2
HERC5	2	CDKN1A	1	pull down	Mitsui K (1999)	1
HNRNPU	12	RPL18	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
ISG15	0	ERCC2	4	affinity chromatography technology	Takeuchi T (2006)	1
DGCR8	4	HNRNPU	12	affinity chromatography technology	Shiohama A (2007)	1
NTRK1	1	HNRNPU	12	affinity chromatography technology	Emdal KB (2015)	1
HERC5	2	CCNB1	3	pull down	Mitsui K (1999)	1
FAM234B	0	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	UBE2D1	0	pull down	Saha A (2008)	1
HERC5	2	ERCC2	4	pull down	Takeuchi T (2006)	1
SIRT7	1	RPS2	3	affinity chromatography technology	Tsai YC (2012)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
CCND1	1	CDKN1A	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin J (1996), Guidoboni M (2005), Garcia-Wilson E (2005), Santiago FS (2007), Santiago FS (2007), Zheleva DI (2002), Ruas M (2007), Chen J (1996), Chen J (1996), Poon RY (1996), Ramachandran N (2004), Wang J (2011), Fogeron ML (2013), Rolland T (2014), Yu H (2011), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Welcker M (1998)	21
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
ZC3H3	4	NOP16	2	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
SIRT7	1	RPL10	3	affinity chromatography technology	Tsai YC (2012)	1
RPL10	3	RPS2	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
HERC5	2	CCNA2	1	pull down	Mitsui K (1999)	1
PRKN	1	CCNB1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee SB (2015), Lee SB (2015), Lee SB (2015)	3
HNRNPU	12	HERC5	2	affinity chromatography technology	Hein MY (2015)	1
TP53	0	ERCC2	4	pull down, far western blotting, pull down	Wang XW (1995), Leveillard T (1996), Leveillard T (1996)	3
FOXM1	3	HERC5	2	affinity chromatography technology	Li X (2015)	1
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
ISG15	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Wong JJ (2006)	2
ISG15	0	STK38	0	affinity chromatography technology	Takeuchi T (2006)	1
HERC5	2	HSPA8	4	affinity chromatography technology	Wong JJ (2006)	1
CDKN1A	1	RPS2	3	two hybrid	Vinayagam A (2011)	1
HERC5	2	UBE2D1	0	pull down	Kroismayr R (2004)	1
TP53	0	RPL14	2	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	RPS2	3	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
PRKN	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Staropoli JF (2003), Veeriah S (2010), Veeriah S (2010), Gong Y (2014), Gong Y (2014)	5
CDKN1A	1	SMAD4	9	imaging technique	Chen TC (2014)	1
IRF3	4	HERC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Shi HX (2010), Shi HX (2010), Shi HX (2010), Shi HX (2010)	4
ISG15	0	TXNRD1	2	affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Zhao C (2005)	2
SIRT7	1	RPL14	2	affinity chromatography technology	Tsai YC (2012)	1
HBP1	1	HERC5	2	affinity chromatography technology	Lampert F (2018)	1
NTRK1	1	TXNRD1	2	affinity chromatography technology	Emdal KB (2015)	1
RAN	1	RANBP1	0	two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, pull down, biochemical, x-ray crystallography, biochemical	Ren M (1995), Steggerda SM (2000), Steggerda SM (2000), Ren M (1995), Plafker K (2000), Zolotukhin AS (1997), Bischoff FR (1995), Bompard G (2010), De Luca A (2003), Yokoyama N (1995), Kuhlmann J (1997), Havugimana PC (2012), Seewald MJ (2002), Wan C (2015)	14
NTRK1	1	RPL10	3	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	HSPA8	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2003), Zanon A (2013)	4
RRP8	6	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
RPL10	3	RPL18	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
CCNB1	3	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
RPS2	3	HERC5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNA2	1	TP53	0	pull down	Luciani MG (2000)	1
HNRNPU	12	RPS2	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
HERC5	2	BECN1	2	affinity chromatography technology	Xu D (2015)	1
ZNF2	1	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	HSPA8	4	affinity chromatography technology	Tian Q (2004)	1
CTNNB1	30	HERC5	2	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Park YS (2017)	2
RPL18	0	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
RPL14	2	RRP8	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PITX2	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique	Kioussi C (2002), Kioussi C (2002), Chen TC (2014)	3
NTRK1	1	RPL18	0	affinity chromatography technology	Emdal KB (2015)	1
HERC5	2	TP53	0	affinity chromatography technology	Huang YF (2014)	1
PRKN	1	HNRNPU	12	affinity chromatography technology	Zanon A (2013)	1
PRKN	1	CCND1	1	affinity chromatography technology, enzymatic study	Gong Y (2014), Gong Y (2014)	2
NTRK1	1	ERCC2	4	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	UBE2L6	0	affinity chromatography technology, affinity chromatography technology, pull down	Zhang Y (2000), Um JW (2012), Chaugule VK (2011)	3
TTK	4	HERC5	2	affinity chromatography technology	Hein MY (2015)	1
RPL14	2	HERC5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC59	1	HERC5	2	affinity chromatography technology	Huttlin EL (2017)	1
SIRT7	1	RRP8	6	affinity chromatography technology	Tsai YC (2012)	1
HBP1	1	RAN	1	affinity chromatography technology	Lampert F (2018)	1
RPL10	3	HERC5	2	affinity chromatography technology	Hein MY (2015)	1
ISG15	0	SMAD4	9	affinity chromatography technology	Zhao C (2005)	1
ISG15	0	HERC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Wong JJ (2006), Woods MW (2014)	3
DGCR8	4	HSPA8	4	affinity chromatography technology	Shiohama A (2007)	1
RPL14	2	RPS2	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RPL10	3	RPL14	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
CDKN1A	1	HSPA8	4	affinity chromatography technology	Fogeron ML (2013)	1