PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHMP5	0	CHMP1B	0	two hybrid	Tsang HT (2006)	1
NF2	1	CHMP1A	3	affinity chromatography technology	Zhou L (2015)	1
CLTC	12	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
CHMP1A	3	OAS3	3	biochemical	Havugimana PC (2012)	1
CHMP1A	3	VPS4B	3	two hybrid	von Schwedler UK (2003)	1
MCM2	3	CHMP1A	3	affinity chromatography technology	Drissi R (2015)	1
TFG	3	IST1	0	affinity chromatography technology	Hein MY (2015)	1
IST1	0	VPS4A	4	biochemical	Wan C (2015)	1
ZDHHC17	1	CHMP1A	3	two hybrid	Butland SL (2014)	1
CLTC	12	IST1	0	affinity chromatography technology	Hein MY (2015)	1
NR1I2	5	CHMP1A	3	two hybrid	Albers M (2005)	1
UBE2I	0	CHMP4B	2	two hybrid, two hybrid	Rual JF (2005), Tsang HT (2006)	2
CHMP1A	3	FBXL18	5	biochemical	Havugimana PC (2012)	1
STAMBP	2	CHMP1A	3	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	9
TFG	3	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
CHMP1A	3	UBE2I	0	two hybrid	Tsang HT (2006)	1
NXF1	0	CLTC	12	affinity chromatography technology	Castello A (2012)	1
SIX2	4	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
STAMBP	2	CHMP1B	0	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, two hybrid	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Rolland T (2014)	10
RAB7A	0	RAB5C	2	biochemical	Wan C (2015)	1
MCM2	3	CLTC	12	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	TFG	3	affinity chromatography technology	Drissi R (2015)	1
BROX	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
VSX2	1	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFG	3	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	RAB5C	2	affinity chromatography technology	Castello A (2012)	1
IST1	0	VPS4B	3	biochemical	Wan C (2015)	1
UBE2I	0	NR1I2	5	enzymatic study	Hu G (2010)	1
GOLT1B	0	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
TFG	3	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	CHMP1A	3	affinity chromatography technology	Castello A (2012)	1
RAB5C	2	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
VPS4A	4	CHMP1B	0	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	3
ATP6V1B1	4	CHMP1A	3	affinity chromatography technology	Nylandsted J (2011)	1
HEY2	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
TFG	3	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
GOLT1B	0	LNPK	2	affinity chromatography technology	Hein MY (2015)	1
ZNF524	0	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP5	0	STAMBP	2	two hybrid	Wang J (2011)	1
CHMP1A	3	CHMP1B	0	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
GOLT1B	0	IST1	0	affinity chromatography technology	Hein MY (2015)	1
CLTC	12	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
STAMBP	2	CLTC	12	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), McCullough J (2006), McCullough J (2006), McCullough J (2006), Hein MY (2015)	6
NF2	1	IST1	0	affinity chromatography technology	Zhou L (2015)	1
USP8	7	CHMP1B	0	two hybrid, pull down, affinity chromatography technology, pull down	Row PE (2007), Row PE (2007), Row PE (2007), Rigden DJ (2009)	4
RAB5C	2	IST1	0	affinity chromatography technology	Hein MY (2015)	1
ATP6V1B1	4	CHMP4B	2	affinity chromatography technology	Nylandsted J (2011)	1
GOLT1B	0	RAB5C	2	affinity chromatography technology	Hein MY (2015)	1
CHMP1A	3	VPS4A	4	affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid	Howard TL (2001), Howard TL (2001), Howard TL (2001), von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	6
MOV10	6	CHMP1A	3	affinity chromatography technology	Castello A (2012)	1
MOV10	6	NF2	1	affinity chromatography technology	Castello A (2012)	1
ATP6V1B1	4	CHMP1B	0	affinity chromatography technology	Nylandsted J (2011)	1
VPS4B	3	CHMP5	0	two hybrid	Rolland T (2014)	1
LHX4	1	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP4B	2	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
USP8	7	CHMP1A	3	pull down, pull down	Row PE (2007), Rigden DJ (2009)	2
ATP6V1B1	4	CHMP5	0	affinity chromatography technology	Nylandsted J (2011)	1
RAB5C	2	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
IST1	0	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IST1	0	CHMP1B	0	affinity chromatography technology, biochemical	Xiao J (2009), Wan C (2015)	2
STAMBP	2	CHMP4B	2	two hybrid, two hybrid, two hybrid	Row PE (2007), Tsang HT (2006), Tsang HT (2006)	3
UBE2I	0	NXF1	0	affinity chromatography technology	Hein MY (2015)	1
CHMP1A	3	CHMP1A	3	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
CHMP5	0	CHMP4B	2	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
USP8	7	VPS4B	3	biochemical	Havugimana PC (2012)	1
NXF1	0	NF2	1	affinity chromatography technology	Castello A (2012)	1
RAB7A	0	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
GOLT1B	0	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	VPS4B	3	affinity chromatography technology	Castello A (2012)	1
ZDHHC17	1	VSX2	1	two hybrid	Butland SL (2014)	1
RAB7A	0	IST1	0	affinity chromatography technology	Hein MY (2015)	1
CHMP4B	2	IST1	0	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	RAB7A	0	imaging technique	Kumar B (2016)	1
ATP6V1B1	4	IST1	0	affinity chromatography technology	Nylandsted J (2011)	1
VPS4A	4	CHMP5	0	affinity chromatography technology	Kuang Z (2011)	1
NF2	1	CHMP4B	2	affinity chromatography technology	Zhou L (2015)	1
VPS4A	4	CHMP4B	2	two hybrid, two hybrid	Tsang HT (2006), Tsang HT (2006)	2
CHMP4B	2	MECP2	36	affinity chromatography technology	Hein MY (2015)	1
UBE2I	0	USP8	7	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBE2I	0	HMGN2	1	enzymatic study	Jakobs A (2007)	1
CHMP4B	2	CHMP1B	0	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
MECP2	36	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
GPX7	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
RAB7A	0	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
BROX	0	CHMP4B	2	affinity chromatography technology	Popov S (2009)	1
NXF1	0	MEOX1	0	affinity chromatography technology	Castello A (2012)	1
HMGN2	1	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
HEY2	0	IST1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP5	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
MEOX1	0	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHMP1A	3	LNPK	2	affinity chromatography technology	Ewing RM (2007)	1
LNPK	2	TFG	3	affinity chromatography technology	McGourty CA (2016)	1
MOV10	6	RAB5C	2	affinity chromatography technology	Castello A (2012)	1
VPS4A	4	VPS4B	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CLTC	12	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1