PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBAP1	2	VPS37A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Wunderley L (2014), Stefani F (2011), Huttlin EL (2017)	6
VPS37A	4	TSG101	1	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid	Bache KG (2004), Bache KG (2004), Stuchell MD (2004), Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Rolland T (2014), Stefani F (2011), Albers M (2005)	9
VPS37B	2	VPS28	2	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology	Stuchell MD (2004), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017)	6
BCR	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2000), Million RP (2004), Million RP (2004), Puil L (1994), Puil L (1994), Ma G (1997), Maru Y (1995), Maru Y (1995), Gaston I (2004), Gaston I (2004), Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	13
TSG101	1	DPYSL2	3	biochemical	Wan C (2015)	1
GOLGA2	2	PARD6B	0	two hybrid	Rolland T (2014)	1
ALG2	2	VPS37A	4	affinity chromatography technology	Katoh K (2005)	1
VPS37D	1	TSG101	1	affinity chromatography technology	Huttlin EL (2017)	1
SKIL	3	VPS28	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBC	7	VPS28	2	affinity chromatography technology, pull down	Bishop N (2002), Zhang X (2017)	2
CEP57L1	3	VPS28	2	two hybrid	Yu H (2011)	1
COQ3	4	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	UBAP1	2	pull down, pull down, pull down, pull down	Fenner BJ (2009), Stefani F (2011), Kharitidi D (2015), Zhang X (2017)	4
XPO1	8	VPS52	0	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	TSG101	1	pull down, two hybrid, affinity chromatography technology, two hybrid	Rauch S (2011), Rauch S (2011), Nabhan JF (2012), Nabhan JF (2012)	4
TSG101	1	USHBP1	1	two hybrid	Rolland T (2014)	1
VPS28	2	AKAP11	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS28	2	MAD1L1	2	affinity chromatography technology	Huttlin EL (2015)	1
TRIM14	1	VPS37C	3	bioid	Tan P (2017)	1
VPS28	2	RASSF5	2	two hybrid	Rolland T (2014)	1
XPO1	8	GOLGA2	2	affinity chromatography technology	Kirli K (2015)	1
ALG2	2	VPS28	2	affinity chromatography technology	Katoh K (2005)	1
VPS28	2	VPS25	1	affinity chromatography technology, affinity chromatography technology	Im YJ (2008), Medina GN (2011)	2
SLC25A41	0	MVB12A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS28	2	NIF3L1	0	biochemical	Wan C (2015)	1
XPO1	8	BCR	3	affinity chromatography technology	Kirli K (2015)	1
VPS28	2	PNMA5	0	two hybrid	Rolland T (2014)	1
VPS25	1	VPS36	3	two hybrid, two hybrid, pull down, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	12
VPS28	2	MVB12A	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
UBC	7	VPS37A	4	pull down	Zhang X (2017)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
VPS28	2	SAXO1	1	two hybrid	Rolland T (2014)	1
C22orf23	0	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS28	2	SNF8	2	affinity chromatography technology	Im YJ (2008)	1
VPS28	2	USHBP1	1	two hybrid	Rolland T (2014)	1
SCN2B	1	HIP1R	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	INCA1	1	two hybrid	Rolland T (2014)	1
VPS28	2	INCA1	1	two hybrid	Rolland T (2014)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
GOLGA2	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
VPS36	3	TSG101	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Kumar B (2016), Kumar B (2016)	5
VPS28	2	PCP2	0	affinity chromatography technology	Huttlin EL (2017)	1
VPS37B	2	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
SNF8	2	TSG101	1	two hybrid, two hybrid, two hybrid	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003)	3
GRB2	2	PNMA5	0	two hybrid	Rolland T (2014)	1
TRIM27	2	VPS28	2	two hybrid	Rolland T (2014)	1
SETX	7	VPS28	2	affinity chromatography technology	Huttlin EL (2017)	1
VPS37B	2	NIF3L1	0	biochemical	Wan C (2015)	1
SLC25A41	0	MVB12B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MVB12A	0	VPS37A	4	affinity chromatography technology	Tsunematsu T (2010)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
VPS28	2	KNL1	5	affinity chromatography technology	Huttlin EL (2017)	1
VPS28	2	UBAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Huttlin EL (2015), Huttlin EL (2017)	5
SNF8	2	VPS36	3	two hybrid, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Wan C (2015), Huttlin EL (2017)	9
SLC25A41	0	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS28	2	CARD9	3	two hybrid	Rolland T (2014)	1
XPO1	8	VPS37A	4	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	HAUS8	2	affinity chromatography technology	Kirli K (2015)	1
GOLGA2	2	VPS28	2	two hybrid	Rolland T (2014)	1
VPS28	2	MVB12B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	ABHD17A	1	two hybrid	Yu H (2011)	1
TRIM14	1	VPS28	2	bioid	Tan P (2017)	1
VPS28	2	VPS37D	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	MVB12A	0	affinity chromatography technology	Kirli K (2015)	1
MVB12A	0	VPS37B	2	affinity chromatography technology, biochemical	Wunderley L (2014), Wan C (2015)	2
SMN2	0	VPS28	2	two hybrid	Rolland T (2014)	1
GRB2	2	TSG101	1	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Bisson N (2011)	2
UBC	7	MAD1L1	2	pull down	Nathan JA (2013)	1
TRIM27	2	ABHD17A	1	two hybrid	Yu H (2011)	1
SNF8	2	NIF3L1	0	two hybrid	Rual JF (2005)	1
DPYSL2	3	VPS28	2	biochemical	Wan C (2015)	1
PNMA5	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
VPS52	0	VPS28	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
FN1	17	HIP1R	5	affinity chromatography technology	Humphries JD (2009)	1
UBE2U	0	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSG101	1	VPS28	2	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stuchell MD (2004), Bishop N (2001), von Schwedler UK (2003), Martin-Serrano J (2003), Stefani F (2011), Venkatesan K (2009), Wunderley L (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
CARD9	3	CEP57L1	3	two hybrid	Rolland T (2014)	1
VPS28	2	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	VPS28	2	affinity chromatography technology	Humphries JD (2009)	1
UBE2U	0	TRIM54	1	two hybrid	van Wijk SJ (2009)	1
GRB2	2	MVB12A	0	affinity chromatography technology	Huttlin EL (2017)	1
VPS28	2	BCR	3	affinity chromatography technology	Olabisi OO (2006)	1
XPO1	8	UBAP1	2	affinity chromatography technology	Kirli K (2015)	1
TSG101	1	UBAP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Stefani F (2011), Stefani F (2011), Agromayor M (2012), Agromayor M (2012), Wunderley L (2014), Wunderley L (2014), Wunderley L (2014), Wan C (2015), Kharitidi D (2015), Huttlin EL (2017)	10
GRB2	2	TRIM27	2	two hybrid	Rolland T (2014)	1
ABHD17A	1	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CARD9	3	PNMA5	0	two hybrid	Rolland T (2014)	1
TSG101	1	NIF3L1	0	biochemical	Wan C (2015)	1
UBC	7	VPS37C	3	pull down	Nathan JA (2013)	1
FN1	17	UBC	7	affinity chromatography technology	Humphries JD (2009)	1
VPS28	2	BRCA2	6	affinity chromatography technology	Huttlin EL (2015)	1
CBX5	3	VPS28	2	two hybrid	Rolland T (2014)	1
MBIP	0	STXBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VPS28	2	HAUS8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2U	0	MVB12A	0	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	SMN2	0	affinity chromatography technology	Kirli K (2015)	1
VPS28	2	VPS36	3	affinity chromatography technology, x-ray crystallography	Im YJ (2008), Gill DJ (2007)	2
ALG2	2	TSG101	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Okumura M (2009), Katoh K (2005), Katoh K (2005), Inuzuka T (2010)	4
SMN1	0	SMN2	0	biochemical, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology	Meister G (2000), Meister G (2000), Xin X (2009), Huttlin EL (2015), Huttlin EL (2017)	5
TRIM27	2	NIF3L1	0	two hybrid	Yu H (2011)	1
XPO1	8	VPS28	2	affinity chromatography technology	Kirli K (2015)	1
ARRDC1	4	VPS37A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SCN2B	1	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM54	1	CARD9	3	two hybrid	Rolland T (2014)	1
VPS28	2	SMN1	0	two hybrid	Yu H (2011)	1
MVB12A	0	MVB12B	2	affinity chromatography technology, affinity chromatography technology	Tsunematsu T (2010), Tsunematsu T (2010)	2
UBAP1	2	VPS37B	2	affinity chromatography technology	Huttlin EL (2017)	1
MVB12B	2	TSG101	1	affinity chromatography technology	Tsunematsu T (2010)	1
MVB12B	2	VPS37A	4	affinity chromatography technology	Tsunematsu T (2010)	1
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
BLZF1	0	CARD9	3	two hybrid	Rolland T (2014)	1
XPO1	8	SMN1	0	affinity chromatography technology	Kirli K (2015)	1
VPS28	2	RGPD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	BLZF1	0	affinity chromatography technology	Kirli K (2015)	1
TRIM14	1	DPYSL2	3	bioid	Tan P (2017)	1
GOLGA2	2	UBE2U	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TSG101	1	BCR	3	affinity chromatography technology, two hybrid, pull down	Olabisi OO (2006), Olabisi OO (2006), Olabisi OO (2006)	3
VPS37C	3	VPS28	2	pull down, affinity chromatography technology	Eastman SW (2005), Stefani F (2011)	2
SLC25A41	0	VPS36	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	VPS28	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM27	2	VPS25	1	two hybrid	Rolland T (2014)	1
SNF8	2	VPS25	1	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, two hybrid	Rual JF (2005), Bowers K (2006), Bowers K (2006), Bowers K (2006), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Rolland T (2014), Wan C (2015), Yu H (2011)	11
TRIM54	1	USHBP1	1	two hybrid	Rolland T (2014)	1
TRIM54	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
VPS28	2	STXBP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	ARRDC1	4	affinity chromatography technology	Kirli K (2015)	1
UBE2U	0	TRIM27	2	two hybrid	Markson G (2009)	1
MVB12A	0	TSG101	1	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Tsunematsu T (2010), Wunderley L (2014), Wunderley L (2014), Wan C (2015)	4
UBC	7	BCR	3	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
GOLGA2	2	SNF8	2	two hybrid	Rolland T (2014)	1
VPS28	2	MBIP	0	two hybrid	Rolland T (2014)	1
TCF12	14	VPS28	2	two hybrid	Rolland T (2014)	1
XPO1	8	TCF12	14	affinity chromatography technology	Kirli K (2015)	1
BLZF1	0	VPS28	2	two hybrid	Rolland T (2014)	1
TSG101	1	HIP1R	5	biochemical	Wan C (2015)	1
FN1	17	XPO1	8	affinity chromatography technology	Humphries JD (2009)	1
PARD6B	0	VPS28	2	affinity chromatography technology	Hein MY (2015)	1
TCF4	26	VPS28	2	two hybrid	Rolland T (2014)	1
GRB2	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
VPS37B	2	TSG101	1	pull down, two hybrid, two hybrid, affinity chromatography technology, unspecified method, affinity chromatography technology, biochemical, biochemical	Bache KG (2004), Stuchell MD (2004), Stuchell MD (2004), Stuchell MD (2004), Schlundt A (2009), Agromayor M (2012), Havugimana PC (2012), Wan C (2015)	8
SMN1	0	SETX	7	affinity chromatography technology, affinity chromatography technology	Zhao DY (2016), Zhao DY (2016)	2
VPS37A	4	VPS28	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bache KG (2004), Bache KG (2004), Bache KG (2004), Bache KG (2004), Stefani F (2011), Huttlin EL (2015), Huttlin EL (2017)	7
HIP1R	5	VPS28	2	biochemical	Wan C (2015)	1
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
ARRDC1	4	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNF8	2	TRIM54	1	two hybrid	Rolland T (2014)	1
VPS36	3	UBC	7	x-ray crystallography, pull down, pull down	Alam SL (2006), Alam SL (2006), Langelier C (2006)	3
VPS28	2	TRIM54	1	two hybrid	Rolland T (2014)	1
TSG101	1	VPS37C	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical	Eastman SW (2005), Eastman SW (2005), Stefani F (2011), Stefani F (2011), Wunderley L (2014), Rolland T (2014), Wan C (2015)	7
GOLGA2	2	VPS37C	3	two hybrid	Rolland T (2014)	1
GRB2	2	VPS37B	2	affinity chromatography technology	Huttlin EL (2017)	1
MVB12A	0	VPS37C	3	affinity chromatography technology	Wunderley L (2014)	1