PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PELI2	5	IRAK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Strelow A (2003), Strelow A (2003), Butler MP (2005), Schauvliege R (2006), Huoh YS (2014)	6
IL1RL1	1	MYD88	1	affinity chromatography technology	Schmitz J (2005)	1
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
TRAF6	0	IRAK3	0	affinity chromatography technology	Wesche H (1999)	1
TLR4	5	TRAF6	0	affinity chromatography technology	Yang M (2011)	1
MYD88	1	IRAK4	0	affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Li S (2002), Ulrichts P (2008), Ulrichts P (2008), Zhou J (2011), Zhou J (2011), Burns K (2003), Burns K (2003), Strelow A (2003), Loiarro M (2007), Jeon J (2014), Rolland T (2014)	11
IL1RL1	1	TRAF6	0	affinity chromatography technology	Schmitz J (2005)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
TNFRSF13B	0	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
ARNT	1	IKBKG	0	affinity chromatography technology	Bracken CP (2005)	1
PELI1	1	MYD88	1	affinity chromatography technology	Choi KC (2006)	1
PELI3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xiao H (2008), Jensen LE (2003), Jensen LE (2003), Butler MP (2005), Siednienko J (2012), Siednienko J (2012), Huoh YS (2014)	7
PELI3	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao H (2008), Butler MP (2007), Jensen LE (2003), Jensen LE (2003), Butler MP (2005), Schauvliege R (2006), Huoh YS (2014)	7
TLR4	5	IRAK1	1	affinity chromatography technology	Yang M (2011)	1
IRAK4	0	TLR4	5	affinity chromatography technology	Xiong Y (2011)	1
IRAK4	0	VSIG8	3	affinity chromatography technology	Huttlin EL (2017)	1
IRAK4	0	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
IRAK2	3	PELI1	1	affinity chromatography technology	Butler MP (2007)	1
MYD88	1	IRAK2	3	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Fitzgerald KA (2001), Muzio M (1997), Zhou J (2011)	4
IRAK4	0	PELI2	5	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Butler MP (2007), Strelow A (2003), Strelow A (2003), Strelow A (2003)	4
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
IRAK4	0	PELI1	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006)	6
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TIRAP	1	IRAK2	3	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011)	4
IL1R1	0	MYD88	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Muzio M (1997), Jiang Z (2003), Chen R (2012), Burns K (1998), Jeon J (2014)	6
TIRAP	1	TLR4	5	affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, protein complementation assay, affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology	Horng T (2001), Horng T (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Li S (2011)	9
ARNT	1	IRAK4	0	two hybrid	Wang J (2011)	1
TNFRSF13B	0	IRAK4	0	affinity chromatography technology	He B (2010)	1
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
IL1R1	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2002), Chen R (2012), Cao Z (1996), Cao Z (1996), Rao N (2005), Jeon J (2014)	8
IRAK4	0	HIST1H1E	5	enzymatic study	Rininsland F (2005)	1
IL1R1	0	IRAK4	0	affinity chromatography technology	Jiang Z (2003)	1
IRAK4	0	HIST1H1T	3	enzymatic study	Rininsland F (2005)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
TNFRSF13B	0	MYD88	1	affinity chromatography technology	He B (2010)	1
MYD88	1	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
IRAK2	3	IL1R1	0	affinity chromatography technology	Muzio M (1997)	1
IRAK3	0	IRAK1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li S (2011), Ross K (2002), Nguyen T (2009)	3
IRAK4	0	MBP	0	enzymatic study	Rininsland F (2005)	1
TIRAP	1	MYD88	1	genetic interference, two hybrid, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, protein complementation assay, affinity chromatography technology	Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Ulrichts P (2010), Ulrichts P (2010)	10
MYD88	1	TLR4	5	two hybrid, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology	Chuang TH (2004), Doyle SE (2003), Rhee SH (2000), Fitzgerald KA (2001), Ulrichts P (2007), Ulrichts P (2008), Ulrichts P (2010), Yang M (2011)	8
IRAK4	0	HIST1H1A	0	enzymatic study	Rininsland F (2005)	1
TIRAP	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRAK4	0	EIF4EBP1	1	enzymatic study	Rininsland F (2005)	1
TRAF6	0	IRAK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Zhang X (2013)	3
IRAK4	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
IL1RL1	1	IRAK4	0	affinity chromatography technology	Schmitz J (2005)	1
IL1RL1	1	IRAK1	1	affinity chromatography technology	Schmitz J (2005)	1
IRAK4	0	TIRAP	1	protein complementation assay, affinity chromatography technology, pull down	Ulrichts P (2008), Li S (2011), Li S (2011)	3
TIRAP	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Mansell A (2004), Verstak B (2009), Verstak B (2009), Ma J (2013)	5
IRAK4	0	IRAK1	1	affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Ulrichts P (2008), Li S (2011), Neumann D (2007), Burns K (2003), Liu G (2007), Strelow A (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Jeon J (2014)	13
PELI1	1	IL1R1	0	affinity chromatography technology	Jiang Z (2003)	1
IL1R1	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2003), Rafferty BJ (2010)	4
IRAK1	1	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
IRAK4	0	HIST1H1C	2	enzymatic study	Rininsland F (2005)	1
PELI2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Jensen LE (2003), Huoh YS (2014)	2
MYD88	1	IRAK3	0	affinity chromatography technology	Wesche H (1999)	1
IRAK4	0	HIST1H1B	4	enzymatic study	Rininsland F (2005)	1
IRAK3	0	IRAK4	0	affinity chromatography technology	Li S (2011)	1
IRAK4	0	PELI3	0	affinity chromatography technology	Butler MP (2007)	1
IKBKG	0	SASH1	8	affinity chromatography technology	Dauphinee SM (2013)	1
TNFRSF13B	0	IRAK1	1	affinity chromatography technology	He B (2010)	1
HIST1H1T	3	HIST1H1E	5	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	MYD88	1	pull down	Emmerich CH (2013)	1
IRAK2	3	PELI3	0	affinity chromatography technology	Butler MP (2007)	1
IKBKG	0	IRAK1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Conze DB (2008), Conze DB (2008), Windheim M (2008), Windheim M (2008), Ordureau A (2008), Xiong Y (2011), Jeon J (2014), Emmerich CH (2013)	8
IRAK4	0	HIST1H1D	1	enzymatic study	Rininsland F (2005)	1
IRAK3	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
IKBKG	0	IRAK4	0	pull down	Emmerich CH (2013)	1
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
IRAK2	3	PELI2	5	affinity chromatography technology	Butler MP (2007)	1
KIF11	5	IRAK4	0	affinity chromatography technology	Hein MY (2015)	1
PELI1	1	IRAK1	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Lin CC (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006), Choi KC (2006), Butler MP (2005), Schauvliege R (2006), Murphy M (2015)	11