PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAQ	0	HIST1H4A	0	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
KMT5B	16	KMT5B	16	enzymatic study	Zhang X (2013)	1
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
SMARCD1	5	KMT5B	16	two hybrid	Wang J (2011)	1
KMT5B	16	HIST1H4A	0	enzymatic study	Schotta G (2004)	1
BRD1	5	KMT5B	16	affinity chromatography technology	Fryland T (2016)	1
YWHAQ	0	KMT5B	16	affinity chromatography technology	Ewing RM (2007)	1
KMT5B	16	ESR1	0	enzymatic study	Zhang X (2013)	1
SMARCD1	5	ESR1	0	pull down	Hsiao PW (2003)	1