PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSEN1	11	APH1A	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Gu Y (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Hebert SS (2004), Hebert SS (2004), Sato T (2007), Kuo LH (2008)	10
PSEN1	11	PSENEN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Crystal AS (2003), Steiner H (2002), Hebert SS (2004), Yonemura Y (2011)	6
NCSTN	1	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012), Hein MY (2015)	3
MOV10	6	ATF4	2	affinity chromatography technology	Castello A (2012)	1
PSEN1	11	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012)	2
NXF1	0	APH1A	2	affinity chromatography technology	Castello A (2012)	1
APH1A	2	ATF4	2	two hybrid	Wang J (2011)	1
APH1A	2	BHLHE40	5	two hybrid	Wang J (2011)	1
APH1A	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012)	2
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
ELAVL1	0	APH1A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	ERLIN2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
APH1A	2	KLF11	2	two hybrid	Wang J (2011)	1
NCSTN	1	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee SF (2002), Yu G (2000), Hebert SS (2004)	3
BHLHE40	5	HIVEP1	13	two hybrid	Wang J (2011)	1
MOV10	6	CREB3	1	affinity chromatography technology	Castello A (2012)	1
PSEN2	3	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
CREB3	1	APH1A	2	two hybrid	Yu H (2011)	1
NCSTN	1	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Haffner C (2004), Baulac S (2003), Baulac S (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Yu G (2000), Hebert SS (2004), Sato T (2007), Sato T (2007), Kuo LH (2008)	11
NXF1	0	ATF4	2	affinity chromatography technology	Castello A (2012)	1
NCSTN	1	PSENEN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Steiner H (2002), Yonemura Y (2011), Kuo LH (2008)	5
CREB3	1	PSENEN	3	two hybrid	Yu H (2011)	1
CREB3	1	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
RBFOX2	5	GPATCH8	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	KLF11	2	affinity chromatography technology	Abdelmohsen K (2009)	1
APH1A	2	HIVEP1	13	two hybrid	Wang J (2011)	1
APH1A	2	THPO	0	two hybrid	Wang J (2011)	1
APH1A	2	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Lee SF (2002), Hebert SS (2004), Hebert SS (2004)	4
NCSTN	1	APH1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haffner C (2004), Baulac S (2003), Baulac S (2003), LaVoie MJ (2003), Gu Y (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Lee SF (2002), Hebert SS (2004), Suzuki Y (2009), Sato T (2007), Kuo LH (2008), Kuo LH (2008)	14
HES1	0	TLE1	6	pull down, affinity chromatography technology, affinity chromatography technology	Buscarlet M (2008), Tremblay CS (2009), Tremblay CS (2009)	3
MOV10	6	APH1A	2	affinity chromatography technology	Castello A (2012)	1
ELAVL1	0	HES1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
APH1A	2	RBFOX2	5	two hybrid	Wang J (2011)	1
ELAVL1	0	BHLHE40	5	affinity chromatography technology	Abdelmohsen K (2009)	1
APH1A	2	GPATCH8	5	two hybrid	Wang J (2011)	1
APH1A	2	APH1A	2	affinity chromatography technology	Hebert SS (2004)	1
ELAVL1	0	RBFOX2	5	affinity chromatography technology, two hybrid, two hybrid	Abdelmohsen K (2009), Hegele A (2012), Hegele A (2012)	3
PSENEN	3	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012)	2
PSENEN	3	APH1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Kimberly WT (2003), Hebert SS (2004), Suzuki Y (2009), Sato T (2007), Yonemura Y (2011), Kuo LH (2008)	8
PSENEN	3	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Steiner H (2002), Hebert SS (2004), Yonemura Y (2011)	3
APH1A	2	HES1	0	two hybrid	Wang J (2011)	1
ELAVL1	0	NCSTN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
APH1A	2	TLE1	6	two hybrid	Wang J (2011)	1
GLP1R	4	APH1A	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2