PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CENPJ	6	CSPP1	7	bioid	Gupta GD (2015)	1
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
LCA5	1	CEP131	9	bioid	Gupta GD (2015)	1
SPICE1	2	RPGRIP1L	2	bioid	Gupta GD (2015)	1
SSX2IP	0	CSPP1	7	bioid	Gupta GD (2015)	1
LCA5	1	IFT81	3	affinity chromatography technology	Gupta GD (2015)	1
MED4	2	KIAA0753	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CCDC14	2	SSX2IP	0	affinity chromatography technology	Hein MY (2015)	1
CEP162	3	RPGRIP1L	2	bioid	Gupta GD (2015)	1
OFD1	3	CEP72	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SPICE1	2	CSPP1	7	bioid	Gupta GD (2015)	1
CENPJ	6	KIF7	3	bioid	Firat-Karalar EN (2014)	1
CEP162	3	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CENPJ	6	SSX2IP	0	bioid	Gupta GD (2015)	1
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
MED4	2	CCDC14	2	bioid	Lambert JP (2015)	1
PCNT	10	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
LCA5	1	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
LCA5	1	CEP170	4	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
RPGRIP1L	2	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CCDC14	2	MIB1	5	affinity chromatography technology	Hein MY (2015)	1
CCDC14	2	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
RPGRIP1L	2	PCNT	10	affinity chromatography technology	Gupta GD (2015)	1
MED4	2	PCNT	10	bioid	Lambert JP (2015)	1
SPICE1	2	CEP72	0	bioid	Gupta GD (2015)	1
OFD1	3	HAUS2	2	bioid	Gupta GD (2015)	1
LCA5	1	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
RPGRIP1L	2	CEP131	9	bioid	Gupta GD (2015)	1
CEP162	3	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	PCNT	10	bioid	Firat-Karalar EN (2014)	1
HAUS2	2	CEP72	0	affinity chromatography technology	Hein MY (2015)	1
MED4	2	CEP131	9	bioid	Lambert JP (2015)	1
CEP162	3	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP170	4	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCNT	10	MIB1	5	affinity chromatography technology	Hein MY (2015)	1
MED4	2	MIB1	5	bioid	Lambert JP (2015)	1
PCM1	5	RPGRIP1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP162	3	CSPP1	7	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	KIF7	3	bioid	Gupta GD (2015)	1
RPGRIP1L	2	CSPP1	7	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	KIAA0753	1	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MED4	2	KIF7	3	bioid	Lambert JP (2015)	1
SSX2IP	0	OFD1	3	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
KIAA0753	1	CEP131	9	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
LCA5	1	CEP162	3	bioid	Gupta GD (2015)	1
OFD1	3	IFT81	3	bioid	Gupta GD (2015)	1
KIAA0753	1	CSPP1	7	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
SSX2IP	0	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CENPJ	6	CEP170	4	bioid	Gupta GD (2015)	1
CCDC14	2	CSPP1	7	affinity chromatography technology	Hein MY (2015)	1
PCM1	5	CEP72	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, bioid	Rual JF (2005), Xin X (2009), Fogeron ML (2013), Gupta GD (2015), Gupta GD (2015)	5
SPICE1	2	KIAA0753	1	bioid	Gupta GD (2015)	1
SSX2IP	0	KIAA0753	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
LCA5	1	CEP72	0	bioid	Gupta GD (2015)	1
CCDC14	2	HAUS2	2	bioid	Firat-Karalar EN (2014)	1
IFT81	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CEP162	3	MIB1	5	affinity chromatography technology	Gupta GD (2015)	1
KIF7	3	CEP72	0	affinity chromatography technology	Hein MY (2015)	1
RPGRIP1L	2	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
SPICE1	2	HAUS2	2	bioid	Gupta GD (2015)	1
SSX2IP	0	MIB1	5	affinity chromatography technology	Gupta GD (2015)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CCDC14	2	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CENPJ	6	CEP131	9	bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015)	3
CEP162	3	KIAA0753	1	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
SPICE1	2	SSX2IP	0	bioid	Gupta GD (2015)	1
KIAA0753	1	CEP170	4	bioid	Gupta GD (2015)	1
SPICE1	2	KIF7	3	bioid	Gupta GD (2015)	1
HAUS2	2	PCM1	5	affinity chromatography technology, bioid, affinity chromatography technology	Fogeron ML (2013), Gupta GD (2015), Hein MY (2015)	3
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SPICE1	2	CEP131	9	bioid	Gupta GD (2015)	1
MED4	2	OFD1	3	bioid	Lambert JP (2015)	1
CEP170	4	CEP131	9	bioid	Gupta GD (2015)	1
CENPJ	6	OFD1	3	bioid	Gupta GD (2015)	1
PCM1	5	KIF7	3	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CENPJ	6	KIAA0753	1	bioid	Gupta GD (2015)	1
OFD1	3	CEP170	4	bioid	Gupta GD (2015)	1
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
PCM1	5	CEP131	9	affinity chromatography technology, pull down, affinity chromatography technology, bioid	Akimov V (2011), Villumsen BH (2013), Gupta GD (2015), Gupta GD (2015)	4
MED4	2	IFT81	3	bioid	Lambert JP (2015)	1
MED4	2	HAUS2	2	bioid	Lambert JP (2015)	1
LCA5	1	MED4	2	bioid	Gupta GD (2015)	1
RPGRIP1L	2	SSX2IP	0	bioid	Gupta GD (2015)	1
KIAA0753	1	OFD1	3	bioid, bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	4
MED4	2	CEP72	0	bioid	Lambert JP (2015)	1
PCM1	5	CENPJ	6	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
PCM1	5	MIB1	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, bioid	Akimov V (2011), Villumsen BH (2013), Cajanek L (2015), Gupta GD (2015), Gupta GD (2015)	5
SSX2IP	0	KIF7	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
HAUS2	2	CEP170	4	affinity chromatography technology	Fogeron ML (2013)	1
HAUS2	2	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
CEP162	3	HAUS2	2	bioid	Gupta GD (2015)	1
MED4	2	SSX2IP	0	bioid	Lambert JP (2015)	1
LCA5	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
PCNT	10	OFD1	3	affinity chromatography technology	Hein MY (2015)	1
PCNT	10	CEP72	0	affinity chromatography technology	Hein MY (2015)	1
CCDC14	2	CEP72	0	bioid, affinity chromatography technology	Firat-Karalar EN (2014), Hein MY (2015)	2
PCNT	10	PCM1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2001), Li Q (2001), Gupta GD (2015), Hein MY (2015)	4
CEP162	3	CEP72	0	bioid	Gupta GD (2015)	1
CSPP1	7	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
LCA5	1	CSPP1	7	bioid	Gupta GD (2015)	1
OFD1	3	CSPP1	7	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MED4	2	CEP170	4	bioid	Lambert JP (2015)	1
CEP162	3	PCNT	10	affinity chromatography technology	Gupta GD (2015)	1
CENPJ	6	MIB1	5	bioid	Firat-Karalar EN (2014)	1
LCA5	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
OFD1	3	MIB1	5	affinity chromatography technology	Hein MY (2015)	1
LCA5	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
KIAA0753	1	HAUS2	2	bioid	Gupta GD (2015)	1
MED4	2	CEP162	3	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
CCDC14	2	OFD1	3	bioid, bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015), Hein MY (2015)	4
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
MED4	2	CSPP1	7	bioid	Lambert JP (2015)	1
MED4	2	SPICE1	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CEP162	3	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	CEP72	0	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
SPICE1	2	CENPJ	6	bioid	Gupta GD (2015)	1
PCM1	5	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
KIF7	3	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
CEP131	9	MIB1	5	affinity chromatography technology, pull down	Villumsen BH (2013), Villumsen BH (2013)	2