PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PIN1	0	RELA	1	affinity chromatography technology	Ryo A (2003)	1
ZBTB7B	6	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Rui J (2012), Rui J (2012)	2
RELA	1	CEBPZ	4	affinity chromatography technology	Beauchef G (2012)	1
ZBTB7B	6	PRPF8	14	affinity chromatography technology	Zhang M (2010)	1
BCL6	6	HDAC5	4	affinity chromatography technology, pull down, affinity chromatography technology	Lemercier C (2002), Lemercier C (2002), Miles RR (2005)	3
MORF4L2	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayakawa T (2007), Hayakawa T (2010), Jacquet K (2016), Huttlin EL (2017)	4
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
TRIM25	5	RPL9	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF2	1	MYBBP1A	8	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	PRPF8	14	affinity chromatography technology	Cao Q (2014)	1
ZBTB5	0	ZBTB7B	6	two hybrid	Rolland T (2014)	1
ZBTB7B	6	SP3	4	affinity chromatography technology	Kypriotou M (2007)	1
GRB2	2	EP300	36	two hybrid	Bandyopadhyay S (2010)	1
KPNA2	0	RELA	1	pull down, two hybrid	Cunningham MD (2003), Wang J (2011)	2
KAT5	1	HDAC3	5	affinity chromatography technology	Yi J (2014)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RNF2	1	RELA	1	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	PRPF8	14	affinity chromatography technology	Choudhury NR (2017)	1
RNF2	1	CEBPZ	4	affinity chromatography technology	Cao Q (2014)	1
KPNA2	0	ZBTB7B	6	two hybrid	Wang J (2011)	1
HDAC3	5	SP1	0	affinity chromatography technology	Huang W (2006)	1
EP300	36	KPNA2	0	enzymatic study	Bannister AJ (2000)	1
SP1	0	RELA	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuang PP (2002), Sif S (1994), Sif S (1994), Kao YS (2008), Kao YS (2008), Benjamin JT (2010), Beauchef G (2012), Xu Y (2008)	8
HDAC4	10	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Fischle W (2002), Fischle W (2002), Fischle W (2001), Grozinger CM (2000), Wang X (2008)	7
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
MORF4L2	0	KPNA2	0	affinity chromatography technology	Hayakawa T (2007)	1
GRB2	2	ZBTB7B	6	two hybrid	Rolland T (2014)	1
GRB2	2	KPNA2	0	two hybrid	Wang J (2011)	1
PIN1	0	EP300	36	pull down	Yi P (2005)	1
NDN	0	ZBTB7B	6	two hybrid	Corominas R (2014)	1
ZNF277	1	ZBTB7B	6	two hybrid	Ravasi T (2010)	1
BCL6	6	HDAC4	10	affinity chromatography technology, pull down, affinity chromatography technology	Lemercier C (2002), Lemercier C (2002), Miles RR (2005)	3
KAT5	1	ZBTB7B	6	affinity chromatography technology, affinity chromatography technology	Li Y (2013), Li Y (2013)	2
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	ZNF277	1	affinity chromatography technology	Choudhury NR (2017)	1
ZBTB7B	6	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang M (2010), Zhang M (2010), Zhang M (2010)	3
HDAC3	5	BCL6	6	imaging technique, affinity chromatography technology, affinity chromatography technology	Xu F (2016), Xu F (2016), Xu F (2016)	3
SP1	0	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mottet D (2009), Mottet D (2009), Wilson AJ (2008)	3
HDAC3	5	PIN1	0	affinity chromatography technology	Rajendran P (2011)	1
TFAP4	3	SP3	4	affinity chromatography technology	Ku WC (2009)	1
ZBTB7B	6	IMP4	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZBTB7B	6	CEBPZ	4	affinity chromatography technology	Zhang M (2010)	1
ZBTB7B	6	HSPH1	0	affinity chromatography technology	Zhang M (2010)	1
MYBBP1A	8	RELA	1	affinity chromatography technology	Milanovic M (2013)	1
ZBTB7B	6	MYBBP1A	8	affinity chromatography technology	Zhang M (2010)	1
PIN1	0	ZBTB7B	6	two hybrid	Rolland T (2014)	1
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
HDAC10	3	ZBTB7B	6	affinity chromatography technology	Rui J (2012)	1
ZBTB7B	6	SYTL4	0	two hybrid	Rolland T (2014)	1
HDAC3	5	ZBTB7B	6	affinity chromatography technology	Rui J (2012)	1
KAT5	1	RELA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Kim JW (2012), Kim JW (2012), Kim JW (2012)	3
SP1	0	PIN1	0	affinity chromatography technology, affinity chromatography technology	Yang HC (2014), Yang HC (2014)	2
EP300	36	BCL6	6	enzymatic study, affinity chromatography technology	Bereshchenko OR (2002), Bereshchenko OR (2002)	2
EP300	36	MYBBP1A	8	affinity chromatography technology	Kumazawa T (2011)	1
TFAP4	3	SP1	0	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
TRIM25	5	KPNA2	0	affinity chromatography technology	Choudhury NR (2017)	1
NDN	0	P4HA3	3	two hybrid	Corominas R (2014)	1
BCL6	6	ZBTB7B	6	two hybrid	Rolland T (2014)	1
HDAC5	4	RPL9	1	affinity chromatography technology	Greco TM (2011)	1
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
MYBBP1A	8	PRPF8	14	biochemical	Wan C (2015)	1
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
ZBTB7B	6	ZBTB7B	6	affinity chromatography technology	Zhang M (2010)	1
SORBS3	5	ZBTB7B	6	two hybrid	Rolland T (2014)	1
EP300	36	KAT5	1	affinity chromatography technology, affinity chromatography technology	Col E (2005), Col E (2005)	2
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
ZBTB7B	6	HDAC5	4	affinity chromatography technology, affinity chromatography technology	Rui J (2012), Rui J (2012)	2
NCK2	2	ZBTB7B	6	two hybrid	Rolland T (2014)	1
TRIM25	5	MYBBP1A	8	affinity chromatography technology	Choudhury NR (2017)	1
RPL9	1	ZBTB7B	6	two hybrid	Rolland T (2014)	1
EP300	36	SP3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Choi HS (2002), Walker GE (2001)	3
RELA	1	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Chen Lf (2001), Hu J (2004), Hu J (2004)	4
TFAP4	3	ZBTB7B	6	affinity chromatography technology	Ku WC (2009)	1
RELA	1	ZBTB7B	6	affinity chromatography technology	Beauchef G (2012)	1
MORF4L2	0	ZBTB7B	6	two hybrid	Rolland T (2014)	1
SP3	4	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Goto T (2006), Goto T (2006), Choi HS (2002), Choi HS (2002), Walker GE (2001), Walker GE (2001), Xu Q (2000), Tang S (2004), Kwon JH (2003), Syddall CM (2013), Syddall CM (2013), Syddall CM (2013)	12
RNF2	1	ZBTB7B	6	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	ZBTB7B	6	affinity chromatography technology	Choudhury NR (2017)	1
SH3KBP1	1	ZBTB7B	6	two hybrid	Rolland T (2014)	1
BCL6	6	PIN1	0	affinity chromatography technology, affinity chromatography technology, pull down	Phan RT (2007), Phan RT (2007), Phan RT (2007)	3
GRAP2	0	ZBTB7B	6	two hybrid	Rual JF (2005)	1
HDAC5	4	PRPF8	14	affinity chromatography technology	Greco TM (2011)	1
RNF2	1	RPL9	1	affinity chromatography technology	Cao Q (2014)	1
P4HA3	3	ZBTB7B	6	affinity chromatography technology	Huttlin EL (2017)	1
ZBTB7B	6	SP1	0	affinity chromatography technology	Kypriotou M (2007)	1
HDAC10	3	HDAC3	5	affinity chromatography technology	Tong JJ (2002)	1
CDK2AP1	1	ZBTB7B	6	affinity chromatography technology	Hein MY (2015)	1
PIN1	0	PRPF8	14	pull down	Ingham RJ (2005)	1
RELA	1	SP3	4	affinity chromatography technology	Beauchef G (2012)	1
SH3YL1	1	ZBTB7B	6	two hybrid	Rolland T (2014)	1
TRIM25	5	P4HA3	3	affinity chromatography technology	Choudhury NR (2017)	1