PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ASCC3	12	XPO1	8	genetic interference	Horlbeck MA (2018)	1
ELAVL1	0	SKA1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	ASCC1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FGG	1	FGB	2	x-ray crystallography	Kostelansky MS (2002)	1
SOD1	0	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
TRAF2	1	ASCC1	0	two hybrid	Rolland T (2014)	1
NCOA1	6	TRIP4	2	two hybrid, pull down	Kim HJ (1999), Kim HJ (1999)	2
ASCC1	0	TRIP4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
TRIP4	2	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
ASCC1	0	SERPINB4	1	affinity chromatography technology	Huttlin EL (2017)	1
ASCC1	0	C3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC1	0	FGB	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKA1	0	ASCC1	0	affinity chromatography technology	Hein MY (2015)	1
NCOA6	6	ASCC1	0	pull down	Lee SK (1999)	1
ASCC1	0	3514	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOD1	0	ASCC1	0	affinity chromatography technology	Hein MY (2015)	1
ASCC1	0	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
ESR1	0	NCOA1	6	pull down, pull down, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	DiRenzo J (2000), Sheppard HM (2001), Kalkhoven E (1998), Kang YK (2002), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Tremblay A (2001), Llopis J (2000), Chien PY (1999), Webb P (1998), Webb P (1998), Lazennec G (1997), Heery DM (1997), Heery DM (1997), Torchia J (1997), Torchia J (1997), Fleming FJ (2004), Fujita T (2003), Fujita T (2003), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Gong EY (2010), Eng FC (1998), Needham M (2000), Needham M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Albers M (2005), Kurtev V (2004), DiRenzo J (1997), Han SJ (2016), Han SJ (2016)	37
ASCC1	0	IGLL5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALKBH3	1	ASCC3	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Zhao Y (2015), Zhao Y (2015), Huttlin EL (2017)	4
ASCC1	0	PNMA2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
EP300	36	TRIP4	2	two hybrid	Kim HJ (1999)	1
ALKBH3	1	ASCC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC2	3	TRIP4	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
ASCC2	3	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
ASCC1	0	EP300	36	affinity chromatography technology	Yoo HM (2014)	1
SERPINB3	0	SERPINB4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALKBH3	1	TRIP4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ESR1	0	SERPINB4	1	affinity chromatography technology	Tarallo R (2011)	1
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
SMC6	3	ASCC1	0	affinity chromatography technology	Hein MY (2015)	1
EP300	36	TRAF2	1	two hybrid	Wang J (2011)	1
ASCC1	0	ASCC3	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALKBH3	1	ASCC2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
ASCC1	0	3500	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC1	0	CPA4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC1	0	UFSP2	1	affinity chromatography technology, affinity chromatography technology	Yoo HM (2014), Yoo HM (2014)	2
ESR1	0	CSRP1	0	two hybrid	Arroyo R (2015)	1
ASCC1	0	SERPINB3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	ASCC1	0	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	TRIP4	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ASCC1	0	affinity chromatography technology	Kirli K (2015)	1
NCOA6	6	EP300	36	affinity chromatography technology, pull down	Ko L (2000), Ko L (2000)	2
NCOA6	6	NCOA1	6	pull down, pull down, two hybrid, affinity chromatography technology	Surapureddi S (2011), Lee SK (1999), Lee SK (1999), Goo YH (2003)	4
XPO1	8	FGFR1OP	0	affinity chromatography technology	Kirli K (2015)	1
ESR1	0	TRIP4	2	pull down	Kim HJ (1999)	1
ASCC1	0	NCOA1	6	affinity chromatography technology	Yoo HM (2014)	1
ASCC1	0	3501	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC1	0	FGG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC1	0	CALML5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASCC1	0	ASCC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
FGFR1OP	0	ASCC1	0	affinity chromatography technology	Hein MY (2015)	1
CSNK2A2	1	ASCC1	0	affinity chromatography technology	Hein MY (2015)	1
ASCC1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Yoo HM (2014), Yoo HM (2014)	2
XPO1	8	CSNK2A2	1	affinity chromatography technology	Kirli K (2015)	1
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
NCOA6	6	ESR1	0	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (1999), Lee SK (1999), Ko L (2002), Ko L (2002), Ju BG (2006), Mahajan MA (2000), Mahajan MA (2000), Caira F (2000), Han SJ (2016)	9
ASCC2	3	ASCC3	12	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2