Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
FOXP3 50943 EPIRUBICIN CHEMBL417 CIViC 22431701

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
FOXP3 rs3761548 G methotrexate other yes Patients with moderate to severe psoriasis included. Primary endpoint was a decrease in Psoriasis Area Severity Index (PASI) score of 75 (75% decrease in score) after 12 weeks of MTX treatment. Patients with a PASI score above 50 were considered responders while those below were considered non-responders. Allele G is associated with decreased response to methotrexate in people with Psoriasis as compared to allele T. 28444425 1448616510