PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	F11R	0	bioid	Guo Z (2014)	1
F11R	0	CASK	18	affinity chromatography technology, pull down	Martinez-Estrada OM (2001), Ebnet K (2000)	2
BDNF	0	F11R	0	two hybrid	Wang J (2011)	1
ELAVL1	0	CASK	18	affinity chromatography technology	Abdelmohsen K (2009)	1
IL12A	0	F11R	0	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	F11R	0	affinity chromatography technology	Hanson D (2014)	1
ELAVL1	0	BDNF	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDH1	4	PARD3	5	bioid	Guo Z (2014)	1
CCDC8	1	AFDN	10	affinity chromatography technology	Hanson D (2014)	1
PRKCZ	5	F11R	0	imaging technique	Chen TC (2014)	1
ELAVL1	0	PEX19	2	affinity chromatography technology	Abdelmohsen K (2009)	1
F11R	0	PEX19	2	two hybrid	Wang J (2011)	1
TMEM216	0	F11R	0	bioid	Gupta GD (2015)	1
CDH1	4	AFDN	10	bioid	Guo Z (2014)	1
ELAVL1	0	TJP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SGTA	1	F11R	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
CCDC8	1	TJP1	2	affinity chromatography technology	Hanson D (2014)	1
TJP1	2	AFDN	10	pull down, affinity chromatography technology	Yamamoto T (1999), Yamamoto T (1999)	2
ELAVL1	0	F11R	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PARD3	5	TJP1	2	imaging technique	Suzuki A (2001)	1
MBLAC2	1	F11R	0	affinity chromatography technology	Huttlin EL (2017)	1
PICK1	2	F11R	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC8	1	ELAVL1	0	affinity chromatography technology	Hanson D (2014)	1
PARD3	5	PRKCZ	5	affinity chromatography technology	Kohjima M (2002)	1
F11R	0	TJP1	2	two hybrid, pull down, pull down, affinity chromatography technology	Ebnet K (2000), Ebnet K (2003), Ebnet K (2000), Ebnet K (2000)	4
F11R	0	AFDN	10	pull down, affinity chromatography technology	Ebnet K (2000), Ebnet K (2000)	2
PARD3	5	F11R	0	pull down	Ebnet K (2003)	1
ELAVL1	0	TMEM216	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDH1	4	TJP1	2	bioid	Guo Z (2014)	1