PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
ASAP3	2	RAB11FIP3	2	affinity chromatography technology	Inoue H (2008)	1
CTTN	1	ASAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lynch DK (2003), Bharti S (2007), Bharti S (2007), Onodera Y (2005), Onodera Y (2005), Hashimoto S (2006)	6
ASAP1	1	RAB11FIP3	2	affinity chromatography technology, affinity chromatography technology, pull down	Inoue H (2008), Inoue H (2008), Inoue H (2008)	3
NCK2	2	PTK2	2	pull down, affinity chromatography technology	Goicoechea SM (2002), Goicoechea SM (2002)	2
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	PTPN12	2	affinity chromatography technology	Emdal KB (2015)	1
ASAP1	1	CBLB	3	affinity chromatography technology	Nam JM (2007)	1
SH3KBP1	1	CRK	0	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
PTPN12	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
PACSIN2	0	PACSIN1	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Bandyopadhyay S (2010), Rolland T (2014), Huttlin EL (2017)	8
PACSIN2	0	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
ELAVL1	0	ASAP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
FCHSD1	2	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
CRK	0	ASAP1	1	pull down, affinity chromatography technology	Brown MT (1998), Brehme M (2009)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
ASAP3	2	ASAP1	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
SH3KBP1	1	ASAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havrylov S (2009), Nam JM (2007), Nam JM (2007), Huttlin EL (2017)	4
ARF1	1	PXN	1	imaging technique	Luo R (2005)	1
PTPN12	2	PXN	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, bioid, affinity chromatography technology	Shen Y (2000), Shen Y (2000), Shen Y (2000), Cote JF (1999), Cote JF (1999), Shen Y (1998), Shen Y (1998), St-Denis N (2016), Huttlin EL (2017)	9
ARF6	0	RAB11FIP3	2	pull down, imaging technique, affinity chromatography technology, pull down	Fielding AB (2005), Fielding AB (2005), Fielding AB (2005), Inoue H (2008)	4
PXN	1	ASAP1	1	pull down, affinity chromatography technology	Oshiro T (2002), Hashimoto S (2006)	2
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CDH1	4	ASAP1	1	bioid	Guo Z (2014)	1
TRIM25	5	ASAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
PTK2	2	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2003)	1
CDH1	4	PACSIN2	0	bioid	Guo Z (2014)	1
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
RAB11FIP2	2	ASAP1	1	affinity chromatography technology	Inoue H (2008)	1
RAB11FIP1	2	ASAP1	1	affinity chromatography technology	Inoue H (2008)	1
SH3KBP1	1	CBLB	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Szymkiewicz I (2002), Szymkiewicz I (2002), Szymkiewicz I (2002), Havrylov S (2009), Moncalian G (2006), Jozic D (2005), Jozic D (2005), Kowanetz K (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	11
NCK2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buvall L (2013), Buvall L (2013), Huttlin EL (2015), Huttlin EL (2017)	4
NTRK1	1	PTK2	2	affinity chromatography technology	Emdal KB (2015)	1
CBL	7	PXN	1	affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Salgia R (1996)	2
ELAVL1	0	SH3KBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CDH1	4	PXN	1	bioid	Guo Z (2014)	1
LRRK1	12	ASAP1	1	affinity chromatography technology	Titz B (2010)	1
SRC	2	ASAP1	1	two hybrid, pull down, affinity chromatography technology	Brown MT (1998), Brown MT (1998), Brown MT (1998)	3
TRIM25	5	PTK2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RAB11FIP3	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RAB11FIP1	2	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN1	0	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
CRK	0	ASAP3	2	affinity chromatography technology	Brehme M (2009)	1
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
CTTN	1	PTK2	2	affinity chromatography technology	Bharti S (2007)	1
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
ASAP1	1	ARF6	0	affinity chromatography technology, pull down	Yano H (2008), Klein S (2006)	2
RAB11FIP1	2	RAB11FIP2	2	affinity chromatography technology	Cullis DN (2002)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
PXN	1	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovacic-Milivojevic B (2001), Matsuya M (1998), Turner CE (1999), Liu S (2002), Liu S (2002), Mazaki Y (1997), Zheng C (1998), Brown MC (1996), Fujita H (1998), Zhang Z (1999), Wang JF (2000), Ivankovic-Dikic I (2000)	12
CBLB	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ettenberg SA (1999), Lavagna-Sevenier C (1998), Lavagna-Sevenier C (1998), Elly C (1999), Bandyopadhyay S (2010), Vinayagam A (2011), Bisson N (2011), Blagoev B (2003), Rolland T (2014), Huttlin EL (2017)	10
LRRK1	12	GRB2	2	affinity chromatography technology, affinity chromatography technology	Titz B (2010), Brehme M (2009)	2
TRIM25	5	PACSIN2	0	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	CTTN	1	affinity chromatography technology	Emdal KB (2015)	1
PTPN12	2	ASAP1	1	bioid	St-Denis N (2016)	1
GRB2	2	PTK2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Sieg DJ (2000), Angers-Loustau A (1999), Hildebrand JD (1996), Messina S (2003), Arold ST (2002), Vinayagam A (2011)	6
NTRK1	1	ARAP3	2	affinity chromatography technology	Emdal KB (2015)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
ARF1	1	ASAP1	1	pull down, enzymatic study, imaging technique	Luo R (2005), Luo R (2005), Luo R (2005)	3
SRC	2	PXN	1	pull down	Angers-Loustau A (1999)	1
GRB2	2	PXN	1	pull down	Angers-Loustau A (1999)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
CDH1	4	SH3KBP1	1	bioid	Guo Z (2014)	1
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
CTTN	1	PXN	1	affinity chromatography technology, imaging technique	Onodera Y (2005), Chen TC (2014)	2
CBL	7	PTK2	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Schmidt MH (2003), Sekine Y (2007)	3
PTPN12	2	NCK2	2	bioid	St-Denis N (2016)	1
NCK2	2	ASAP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARAP3	2	ASAP1	1	affinity chromatography technology	Kowanetz K (2004)	1
ELAVL1	0	CTTN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PTPN12	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology	Charest A (1997), Charest A (1997), Bisson N (2011)	3
GRB2	2	ASAP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Wang J (2011), Huttlin EL (2017)	5
SH3KBP1	1	ARAP3	2	affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004)	2
TRIM25	5	PTPN12	2	affinity chromatography technology	Choudhury NR (2017)	1
PTK2	2	ASAP1	1	affinity chromatography technology	Bharti S (2007)	1
CBLB	3	NCK2	2	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
CDH1	4	CBL	7	bioid	Guo Z (2014)	1
ASAP1	1	CBL	7	affinity chromatography technology	Nam JM (2007)	1
PACSIN3	2	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
PTK2	2	CRK	0	affinity chromatography technology, pull down, two hybrid	Hsia DA (2003), Angers-Loustau A (1999), Grossmann A (2015)	3
CRK	0	PXN	1	pull down, affinity chromatography technology	Angers-Loustau A (1999), Abassi YA (2002)	2
PACSIN1	0	PACSIN3	2	two hybrid, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Rolland T (2014), Huttlin EL (2017)	6
NTRK1	1	ASAP1	1	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
TRIP10	1	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
CRK	0	CBLB	3	affinity chromatography technology, two hybrid, two hybrid	Brehme M (2009), Grossmann A (2015), Grossmann A (2015)	3
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
GRB2	2	CTTN	1	affinity chromatography technology	Brehme M (2009)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	NCK2	2	bioid	Guo Z (2014)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
NTRK1	1	CBLB	3	affinity chromatography technology, affinity chromatography technology	Emdal KB (2015), Emdal KB (2015)	2