PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAX5	7	TBP	0	affinity chromatography technology, pull down	Eberhard D (1999), Eberhard D (1999)	2
RB1	2	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nguyen DX (2004), Nguyen DX (2004), Nguyen DX (2004), Ianari A (2009)	4
MYB	3	KAT2B	2	imaging technique	Jin W (2011)	1
PAX5	7	KAT2B	2	affinity chromatography technology	Perearnau A (2017)	1
PAX5	7	TLE4	5	two hybrid, pull down, affinity chromatography technology, pull down	Eberhard D (2000), Eberhard D (2000), Eberhard D (2000), Milili M (2002)	4
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
PAX5	7	DAXX	5	two hybrid, pull down	Emelyanov AV (2002), Emelyanov AV (2002)	2
RB1	2	PAX5	7	pull down, affinity chromatography technology	Eberhard D (1999), Eberhard D (1999)	2
MYB	3	EP300	36	pull down, imaging technique, affinity chromatography technology, enzymatic study, pull down	Nicot C (2001), Jin W (2011), Sandberg ML (2005), Tomita A (2000), Uttarkar S (2015)	5
TBP	0	EP300	36	affinity chromatography technology	Dallas PB (1997)	1
MYB	3	PAX5	7	affinity chromatography technology	Kishi H (2002)	1
PAX5	7	RUNX1	0	pull down	Libermann TA (1999)	1
EP300	36	PAX5	7	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	He T (2011), He T (2011), He T (2011), He T (2011)	4
PAX5	7	CDKN1B	1	affinity chromatography technology	Perearnau A (2017)	1
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
MAPK1	1	PAX5	7	enzymatic study	Yasuda T (2012)	1
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
KAT2B	2	CDKN1B	1	pull down, affinity chromatography technology, pull down, enzymatic study	Perez-Luna M (2012), Perez-Luna M (2012), Perez-Luna M (2012), Perez-Luna M (2012)	4
RB1	2	TBP	0	pull down	Shao Z (1997)	1
RUNX1	0	EP300	36	affinity chromatography technology, enzymatic study	Aikawa Y (2006), Yamaguchi Y (2004)	2
ID3	0	PAX5	7	affinity chromatography technology	Klenova E (2002)	1