PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MBNL1	3	HNRNPK	4	affinity chromatography technology	Paul S (2011)	1
ITSN2	7	REPS1	2	two hybrid	Wong KA (2012)	1
STX4	2	SNAP29	1	pull down	Steegmaier M (1998)	1
FCHSD1	2	ITSN2	7	affinity chromatography technology, two hybrid	Linkermann A (2009), Wong KA (2012)	2
ITSN2	7	TRIO	31	two hybrid	Wong KA (2012)	1
AMPH	4	AP2S1	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HOOK2	0	affinity chromatography technology	Foerster S (2013)	1
ITSN2	7	GOLGA2	2	two hybrid	Wong KA (2012)	1
ITSN2	7	YLPM1	6	two hybrid	Wong KA (2012)	1
ITSN2	7	HNRNPK	4	two hybrid	Wong KA (2012)	1
ITSN2	7	ITPKA	1	two hybrid	Wong KA (2012)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
PSEN1	11	ITSN2	7	two hybrid	Soler-Lopez M (2011)	1
TACC1	2	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
MAP4K3	1	ITSN2	7	two hybrid	Bandyopadhyay S (2010)	1
ITSN2	7	KDM1A	2	two hybrid	Wong KA (2012)	1
ITSN2	7	FNBP4	3	two hybrid	Wong KA (2012)	1
ITSN2	7	SEMA6A	3	two hybrid, two hybrid	Nakayama M (2002), Nakayama M (2002)	2
TACC1	2	KDM1A	2	two hybrid	Weimann M (2013)	1
AP2M1	5	EPS15L1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	3
EGFR	5	BCCIP	1	affinity chromatography technology	Tong J (2014)	1
EPS15	1	AP2S1	1	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2017)	2
ITSN2	7	YTHDF1	1	two hybrid	Thalappilly S (2008)	1
ITSN2	7	DST	13	two hybrid	Wong KA (2012)	1
ITSN2	7	HOOK2	0	two hybrid	Wong KA (2012)	1
ITSN2	7	CHIC2	0	two hybrid	Wong KA (2012)	1
ITSN2	7	DLGAP1	6	two hybrid	Wong KA (2012)	1
AP2M1	5	UBC	7	affinity chromatography technology, pull down	Brehme M (2009), Zhang X (2017)	2
AP2S1	1	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
SOS2	3	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Qian X (2000), Tong J (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014)	7
EGFR	5	HNRNPK	4	affinity chromatography technology	Yao Z (2017)	1
ITSN2	7	PDE4DIP	10	two hybrid	Wong KA (2012)	1
ITSN2	7	SNAP29	1	two hybrid	Wong KA (2012)	1
FBF1	2	CBL	7	bioid	Gupta GD (2015)	1
EGFR	5	MRPL9	0	affinity chromatography technology	Tong J (2014)	1
AP2M1	5	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITSN2	7	WIPF2	1	two hybrid	Wong KA (2012)	1
KHDRBS1	1	ITSN1	5	unspecified method	Asbach B (2012)	1
ITSN2	7	FASLG	0	two hybrid, unspecified method	Wong KA (2012), Voss M (2009)	2
KHDRBS1	1	RBMX	2	two hybrid	Wang J (2011)	1
EGFR	5	ITSN2	7	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ITSN2	7	CCDC88C	7	two hybrid	Wong KA (2012)	1
ITSN2	7	EPS15	1	two hybrid, biochemical	Wong KA (2012), Wan C (2015)	2
UBC	7	AMPH	4	pull down	Stamenova SD (2007)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
EZH2	4	NINL	1	two hybrid	Stelzl U (2005)	1
KHDRBS1	1	SH3KBP1	1	unspecified method, affinity chromatography technology	Asbach B (2012), Havrylov S (2009)	2
ITSN1	5	FCHSD2	3	two hybrid	Wong KA (2012)	1
SH3KBP1	1	WASL	2	affinity chromatography technology	Havrylov S (2009)	1
ITSN1	5	ITSN2	7	protein complementation assay	Wong KA (2012)	1
EGFR	5	AP2S1	1	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013)	2
AMPH	4	REPS1	2	affinity chromatography technology	Dergai O (2010)	1
UBC	7	ITSN2	7	pull down	Zhang X (2017)	1
ITSN2	7	PPP1CC	2	affinity chromatography technology	Titz B (2010)	1
SH3KBP1	1	WIPF2	1	affinity chromatography technology	Havrylov S (2009)	1
SOS1	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
KHDRBS1	1	HNRNPK	4	two hybrid, pull down, affinity chromatography technology, pull down, genetic interference, genetic interference, two hybrid, two hybrid, two hybrid	Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Hegele A (2012), Hegele A (2012), Wang J (2011)	9
NBR1	0	UBC	7	pull down, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down	Waters S (2009), Kirkin V (2009), Walinda E (2014), Walinda E (2014), Nicot AS (2014), Nakayasu ES (2013), Nakayasu ES (2013), Zhang X (2017)	8
ITSN1	5	DLGAP1	6	two hybrid	Wong KA (2012)	1
SYNJ2	2	ITSN2	7	two hybrid, two hybrid	Nakayama M (2002), Wong KA (2012)	2
RNF41	2	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
AMPH	4	ITSN1	5	affinity chromatography technology	Dergai M (2011)	1
EZH2	4	PDCD6IP	3	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
GOLT1B	0	GOLGA2	2	affinity chromatography technology	Hein MY (2015)	1
AP2M1	5	AP2S1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
ITSN2	7	WASF2	0	two hybrid	Wong KA (2012)	1
WASL	2	WIPF2	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
PPP1CC	2	YLPM1	6	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Fardilha M (2011), Huttlin EL (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	8
FNBP4	3	KHDRBS1	1	unspecified method	Goldstrohm AC (2001)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
EGFR	5	WASL	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ITSN1	5	FNBP4	3	two hybrid	Wong KA (2012)	1
PDE4DIP	10	KDM1A	2	two hybrid	Weimann M (2013)	1
PPP4R3A	3	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	DNM2	2	affinity chromatography technology	Tong J (2014)	1
SH3KBP1	1	WIPF1	0	affinity chromatography technology	Havrylov S (2009)	1
UBC	7	HNRNPK	4	affinity chromatography technology	Matsumoto M (2005)	1
ITSN1	5	SYNJ2	2	two hybrid	Wong KA (2012)	1
SOS1	5	ITSN1	5	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Tong XK (2000), Tong XK (2000), Bandyopadhyay S (2010), Tsyba L (2008), Wang JB (2005)	5
DNM2	2	ITSN1	5	two hybrid, pull down, pull down	Vinayagam A (2011), Solomaha E (2005), Elhamdani A (2006)	3
ITSN2	7	CPSF6	1	two hybrid	Wong KA (2012)	1
ITSN2	7	STX4	2	two hybrid	Wong KA (2012)	1
UBC	7	KCTD10	1	affinity chromatography technology	Matsumoto M (2005)	1
ITSN2	7	FCHSD2	3	two hybrid	Wong KA (2012)	1
EGFR	5	YTHDF1	1	affinity chromatography technology	Li J (2013)	1
EZH2	4	CPSF6	1	affinity chromatography technology	Cao Q (2014)	1
ITSN2	7	ERC1	0	two hybrid	Wong KA (2012)	1
ITSN2	7	KCTD10	1	two hybrid	Wong KA (2012)	1
SH3KBP1	1	HNRNPK	4	affinity chromatography technology	Havrylov S (2009)	1
ITSN2	7	GAREM2	1	two hybrid	Wong KA (2012)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
ITSN1	5	EPS15	1	two hybrid, affinity chromatography technology, biochemical	Wong KA (2012), Sengar AS (1999), Wan C (2015)	3
ITSN2	7	SH3KBP1	1	two hybrid	Wong KA (2012)	1
23380	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
ITSN2	7	TACC1	2	two hybrid	Wong KA (2012)	1
ITSN2	7	DNM2	2	two hybrid	Wong KA (2012)	1
SYN1	1	LUC7L3	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	10607	0	affinity chromatography technology	Tong J (2014)	1
FBF1	2	ERC1	0	bioid	Gupta GD (2015)	1
ITSN2	7	AHDC1	28	two hybrid	Wong KA (2012)	1
SH3KBP1	1	KCTD10	1	affinity chromatography technology	Havrylov S (2009)	1
ITSN2	7	GOLGA8A	2	two hybrid	Wong KA (2012)	1
HNRNPK	4	RBMX	2	two hybrid, biochemical, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Rolland T (2014), Yu H (2011)	6
NINL	1	ERC1	0	bioid	Gupta GD (2015)	1
SOS1	5	EGFR	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian X (2000), Qian X (1998), Buday L (1994), Tong J (2009), Kurada BR (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kapoor GS (2010)	9
NCKIPSD	2	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	RNF20	9	affinity chromatography technology	Bish RA (2007)	1
ITSN2	7	RABEP1	4	two hybrid	Wong KA (2012)	1
WASL	2	WIPF1	0	pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Zettl M (2002), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Rolland T (2014), Huttlin EL (2017)	6
EZH2	4	KDM1A	2	two hybrid	Weimann M (2013)	1
KIAA1549	10	ITSN2	7	two hybrid	Nakayama M (2002)	1
KHDRBS1	1	NCKIPSD	2	unspecified method	Asbach B (2012)	1
PDE4DIP	10	FCHSD2	3	two hybrid	Rolland T (2014)	1
ITSN1	5	WASL	2	pull down	Hussain NK (2001)	1
ITSN1	5	PIK3AP1	5	two hybrid	Thalappilly S (2008)	1
ITSN2	7	SOS2	3	two hybrid	Wong KA (2012)	1
ITSN2	7	MBNL1	3	two hybrid	Wong KA (2012)	1
RUFY1	4	RABEP1	4	biochemical	Fouraux MA (2004)	1
NINL	1	ITSN2	7	bioid	Gupta GD (2015)	1
FCHSD2	3	WASL	2	two hybrid	Wang J (2011)	1
FCHSD1	2	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
KDM1A	2	NR2C2	0	affinity chromatography technology, two hybrid	Cui S (2011), Weimann M (2013)	2
PIK3C2B	5	EGFR	5	pull down, two hybrid, protein complementation assay, affinity chromatography technology	Wheeler M (2001), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
PPP1CC	2	RBMX	2	affinity chromatography technology	Hein MY (2015)	1
AP2M1	5	ITSN2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH3GL1	3	KHDRBS1	1	affinity chromatography technology	Cheung N (2007)	1
23380	0	YLPM1	6	affinity chromatography technology	Linkermann A (2009)	1
WAS	0	ITSN2	7	two hybrid, affinity chromatography technology, pull down, two hybrid	McGavin MK (2001), McGavin MK (2001), McGavin MK (2001), Wong KA (2012)	4
SOS1	5	ITSN2	7	two hybrid, two hybrid	Bandyopadhyay S (2010), Wong KA (2012)	2
WAS	0	WIPF1	0	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid	Ramesh N (1997), Ramesh N (1997), Ramesh N (1997), Anton IM (1998), Wang J (2011), Rolland T (2014)	6
ITSN1	5	WAS	0	affinity chromatography technology, affinity chromatography technology	Tsyba L (2008), Wang JB (2005)	2
NCKIPSD	2	FCHSD1	2	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	SH3KBP1	1	pull down, x-ray crystallography, pull down, x-ray crystallography, pull down, x-ray crystallography	Bezsonova I (2008), Korzhnev DM (2009), Ortega Roldan JL (2013), Ortega Roldan JL (2013), Stamenova SD (2007), Bezsonova I (2008)	6
GOLT1B	0	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
ITSN2	7	SH3GL1	3	two hybrid	Wong KA (2012)	1
PDCD6IP	3	SH3GL1	3	affinity chromatography technology, two hybrid	Usami Y (2007), Wang J (2011)	2
ITSN2	7	NBR1	0	two hybrid	Wong KA (2012)	1
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
WAS	0	WIPF2	1	affinity chromatography technology, two hybrid	Aspenstroem P (2002), Wang J (2011)	2
AP2M1	5	REPS1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	4
ITSN1	5	EPS15L1	1	two hybrid, biochemical	Wong KA (2012), Wan C (2015)	2
KHDRBS1	1	ITSN2	7	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Asbach B (2012), Asbach B (2012), Asbach B (2012)	3
AP2S1	1	ITSN2	7	affinity chromatography technology	Huttlin EL (2017)	1
ITSN2	7	WIPF1	0	two hybrid	Wong KA (2012)	1
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
KCTD10	1	LUC7L3	2	genetic interference	Horlbeck MA (2018)	1
KHDRBS1	1	AMPH	4	unspecified method	Asbach B (2012)	1
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
UBC	7	KHDRBS1	1	pull down	Zhang X (2017)	1
SH3KBP1	1	ERC1	0	affinity chromatography technology	Havrylov S (2009)	1
ITSN2	7	TMF1	2	two hybrid	Wong KA (2012)	1
WAS	0	EGFR	5	affinity chromatography technology, affinity chromatography technology	She HY (1997), She HY (1997)	2
GOLT1B	0	PDCD6IP	3	affinity chromatography technology	Hein MY (2015)	1
ITSN2	7	GOLGB1	8	two hybrid	Wong KA (2012)	1
ITSN2	7	SYN1	1	two hybrid	Wong KA (2012)	1
ITSN2	7	KXD1	1	two hybrid	Wong KA (2012)	1
CBL	7	ITSN1	5	far western blotting, two hybrid, affinity chromatography technology, affinity chromatography technology	Martin NP (2006), Thalappilly S (2008), Dergai M (2011), Tsyba L (2008)	4
NCKIPSD	2	ITSN2	7	affinity chromatography technology	Huttlin EL (2017)	1
ITSN2	7	RUFY1	4	two hybrid	Wong KA (2012)	1
KIAA1549	10	DST	13	two hybrid	Nakayama M (2002)	1
DNM2	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schroeder B (2010), Schroeder B (2010), Havrylov S (2009), Wan C (2015)	4
ITSN2	7	BCCIP	1	two hybrid	Stelzl U (2005)	1
ITSN1	5	REPS1	2	affinity chromatography technology	Dergai O (2010)	1
LSM8	0	ITSN2	7	two hybrid	Lehner B (2004)	1
BCCIP	1	PTN	0	two hybrid	Stelzl U (2005)	1
PSEN1	11	UBC	7	imaging technique	Gudey SK (2014)	1
TM9SF4	2	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
ITSN2	7	AGT	3	two hybrid	Wong KA (2012)	1
ITSN1	5	GAREM2	1	two hybrid	Wong KA (2012)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
ITSN2	7	RNF20	9	two hybrid	Wong KA (2012)	1
EGFR	5	LUC7L3	2	affinity chromatography technology	Yao Z (2017)	1
GOLGA2	2	FBF1	2	two hybrid	Rolland T (2014)	1
ITSN2	7	PIK3C2B	5	two hybrid	Wong KA (2012)	1
SYN1	1	AMPH	4	affinity chromatography technology	Onofri F (2000)	1
ITSN2	7	10607	0	two hybrid	Stelzl U (2005)	1
UBC	7	AP2S1	1	pull down	Zhang X (2017)	1
UBC	7	PIK3C2B	5	pull down	Zhang X (2017)	1
ITSN2	7	ROCK1	6	two hybrid	Wong KA (2012)	1
AP2S1	1	REPS1	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
ITSN2	7	CBL	7	two hybrid	Wong KA (2012)	1
EPS15	1	DNM2	2	affinity chromatography technology	Salcini AE (2001)	1
SNAP29	1	RNF20	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITSN2	7	ANKRD17	10	two hybrid	Wong KA (2012)	1
EZH2	4	KHDRBS1	1	affinity chromatography technology	Cao Q (2014)	1
WASF2	0	WASL	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ITSN2	7	PIK3AP1	5	two hybrid	Wong KA (2012)	1
ITSN1	5	PIK3C2B	5	two hybrid	Wong KA (2012)	1
ITSN2	7	WASL	2	two hybrid	Wong KA (2012)	1
ITSN1	5	RABEP1	4	two hybrid	Wong KA (2012)	1
ITSN1	5	PDCD6IP	3	two hybrid	Wong KA (2012)	1
AMPH	4	AP2M1	5	affinity chromatography technology	Huttlin EL (2017)	1
AP2S1	1	EPS15L1	1	affinity chromatography technology	Huttlin EL (2017)	1
FASLG	0	NCKIPSD	2	unspecified method	Voss M (2009)	1
EGFR	5	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
EGFR	5	GOLGB1	8	affinity chromatography technology	Yao Z (2017)	1
FCHSD2	3	WAS	0	two hybrid	Wang J (2011)	1
ITSN2	7	LARP6	1	two hybrid	Wong KA (2012)	1
ITSN2	7	EPS15L1	1	two hybrid, affinity chromatography technology, biochemical	Wong KA (2012), Titz B (2010), Wan C (2015)	3
ITSN2	7	RBMX	2	two hybrid	Wong KA (2012)	1
CPSF6	1	PPP4R3A	3	biochemical	Wan C (2015)	1
ITSN2	7	PDCD6IP	3	two hybrid	Wong KA (2012)	1
MRPL9	0	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
ITSN2	7	LUC7L3	2	two hybrid	Wong KA (2012)	1
WAS	0	CBL	7	affinity chromatography technology	Watanabe Y (2013)	1
ITSN2	7	PTN	0	two hybrid	Stelzl U (2005)	1
DNM2	2	AMPH	4	pull down, pull down	Solomaha E (2005), Elhamdani A (2006)	2
FASLG	0	23380	0	unspecified method	Voss M (2009)	1
EGFR	5	GPNMB	1	enzymatic study	Lin A (2016)	1
ITSN2	7	AMPH	4	two hybrid	Wong KA (2012)	1
SH3KBP1	1	PDCD6IP	3	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Schmidt MH (2004), Rauch S (2011), Havrylov S (2009), Usami Y (2007), Ichioka F (2007), Ichioka F (2007), Schmidt MH (2005), Carlton JG (2008), Chen B (2000)	9
UBC	7	PDCD6IP	3	pull down	Zhang X (2017)	1
ITSN2	7	ITSN2	7	protein complementation assay	Wong KA (2012)	1
ITSN2	7	LTBP4	6	two hybrid	Wong KA (2012)	1
FBF1	2	ITSN2	7	bioid	Gupta GD (2015)	1
23380	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
EZH2	4	ITSN2	7	affinity chromatography technology	Hein MY (2015)	1
FBF1	2	DNM2	2	bioid	Gupta GD (2015)	1
UBC	7	RABEP1	4	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
ITSN2	7	NR2C2	0	two hybrid	Wong KA (2012)	1
NCKIPSD	2	EPS15L1	1	affinity chromatography technology	Huttlin EL (2017)	1
23380	0	ITSN2	7	affinity chromatography technology	Linkermann A (2009)	1
UBC	7	EPS15L1	1	pull down	Zhang X (2017)	1
SH3KBP1	1	SYNJ2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2004), Kowanetz K (2004), Huttlin EL (2017)	4
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
ITSN2	7	GPNMB	1	two hybrid	Wong KA (2012)	1