Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SERPINE1 5054 DEFIBROTIDE CHEMBL2108396 NCI 12745658
SERPINE1 5054 REGRAMOSTIM CHEMBL2107881 NCI 8260700
SERPINE1 5054 NIMODIPINE CHEMBL1428 NCI 11486117
SERPINE1 5054 ESTROGENS, CONJUGATED CHEMBL1201649 NCI 8888658
SERPINE1 5054 VASOPRESSIN CHEMBL373742 NCI 7482412
SERPINE1 5054 UROKINASE CHEMBL1201420 TdgClinicalTrial, DrugBank 12642587, 12745435, 12579271, 12709915, 12785198
SERPINE1 5054 LEVOTHYROXINE CHEMBL1624 NCI 16075920
SERPINE1 5054 DROTRECOGIN ALFA (ACTIVATED) CHEMBL2109065 DrugBank 11259926, 14515185, 17566522, 12004248
SERPINE1 5054 CAPTOPRIL CHEMBL1560 NCI 9152782
SERPINE1 5054 EPIRUBICIN CHEMBL417 NCI 16444429
SERPINE1 5054 FLUOXETINE CHEMBL41 PharmGKB
SERPINE1 5054 TENECTEPLASE CHEMBL2108791 DrugBank 14564902, 17963464, 11163592
SERPINE1 5054 TROGLITAZONE CHEMBL408 antagonist DrugBank 10871202, 10831180, 10418858, 10770198, 10768100
SERPINE1 5054 FIBRINOLYSIN, HUMAN CHEMBL1201505 DrugBank
SERPINE1 5054 CETRORELIX CHEMBL1200490 NCI 16391860
SERPINE1 5054 DALTEPARIN SODIUM CHEMBL1201460 NCI 17057417
SERPINE1 5054 GLYCYRRHIZIN CHEMBL441687 NCI 15070972
SERPINE1 5054 ALEPLASININ CHEMBL325424 inhibitor ChemblInteractions
SERPINE1 5054 RETEPLASE CHEMBL2107885 DrugBank 17963464
SERPINE1 5054 HYDROCHLOROTHIAZIDE CHEMBL435 NCI 11836266
SERPINE1 5054 ORLISTAT CHEMBL175247 NCI 11410822
SERPINE1 5054 URIDINE CHEMBL100259 NCI 10712415
SERPINE1 5054 ANISTREPLASE CHEMBL2108250 DrugBank 17963464
SERPINE1 5054 ETRETINATE CHEMBL464 NCI 8498603
SERPINE1 5054 ALTEPLASE CHEMBL1201593 DrugBank 17963464
SERPINE1 5054 ARSENIC TRIOXIDE CHEMBL1200978 NCI 14619570

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SERPINE1 rs1799889 G citalopram efficacy yes (as part of haplotype with rs2227631-G) Allele G is associated with decreased response to citalopram and fluoxetine in people with Depressive Disorder, Major as compared to allele A. 18794724 655386848
SERPINE1 rs2227631 G citalopram efficacy yes (as haplotype with rs1799889-G) Allele G is associated with decreased response to citalopram and fluoxetine in people with Depressive Disorder, Major as compared to allele A. 18794724 655386834