Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
P2RX7 5027 EVT401 CHEMBL3707396 antagonist TdgClinicalTrial, ChemblInteractions
P2RX7 5027 CHEMBL255787 CHEMBL255787 antagonist GuideToPharmacologyInteractions
P2RX7 5027 METHYCLOTHIAZIDE CHEMBL1577 antagonist GuideToPharmacologyInteractions
P2RX7 5027 CHEMBL550637 CHEMBL550637 antagonist GuideToPharmacologyInteractions
P2RX7 5027 SODIUM ORTHOVANAD CHEMBL179166 antagonist GuideToPharmacologyInteractions
P2RX7 5027 AZD9056 CHEMBL3545108 antagonist ChemblInteractions, TTD
P2RX7 5027 CHEMBL335550 CHEMBL335550 allosteric modulator GuideToPharmacologyInteractions
P2RX7 5027 IVERMECTIN CHEMBL1200633 allosteric modulator GuideToPharmacologyInteractions
P2RX7 5027 CE-224535 CHEMBL1823817 antagonist ChemblInteractions
P2RX7 5027 CHELERYTHRINE CHEMBL13045 allosteric modulator GuideToPharmacologyInteractions
P2RX7 5027 ACEBUTOLOL CHEMBL642 allosteric modulator GuideToPharmacologyInteractions
P2RX7 5027 CHEMBL377219 CHEMBL377219 antagonist GuideToPharmacologyInteractions
P2RX7 5027 CHEMBL2338352 CHEMBL2338352 antagonist GuideToPharmacologyInteractions
P2RX7 5027 GSK1482160 CHEMBL3545206 antagonist ChemblInteractions, TTD
P2RX7 5027 ADENOSINE TRIPHOSPHATE CHEMBL14249 agonist GuideToPharmacologyInteractions
P2RX7 5027 MOCLOBEMIDE CHEMBL86304 allosteric modulator GuideToPharmacologyInteractions
P2RX7 5027 BENZONATATE CHEMBL1374379 antagonist GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
P2RX7 rs1718136 G fentanyl efficacy no No significant association between this variant and 24-h postoperative fentanyl use or perioperative fentanyl use. Allele G is not associated with dose of fentanyl in people with Pain, Postoperative as compared to allele A. 25472448 1450821476
P2RX7 rs1718119 A botulinum toxin type a efficacy no No significant difference in allele frequency between responders and non-responders. Please note that alleles have been complemented to the positive strand. Allele A is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele G. 31014225 1451104961
P2RX7 rs7132846 T fentanyl efficacy no No significant association between this variant and 24-h postoperative fentanyl use or perioperative fentanyl use. Allele T is not associated with dose of fentanyl in people with Pain, Postoperative as compared to allele C. 25472448 1450821482
P2RX7 rs2230912 G botulinum toxin type a efficacy no No significant difference in allele frequency between responders and non-responders. Allele G is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele A. 31014225 1451104940
P2RX7 rs1718125 CT + TT fentanyl dosage yes Patients with the CT or TT genotypes had significantly increased postoperative fentanyl consumption at 6, 24 and 48 hours after surgery. Please note that alleles have been complemented to the positive strand. Genotypes CT + TT are associated with increased dose of fentanyl in people with Lung Neoplasms and Pain, Postoperative as compared to genotype CC. 30762755 1450934857
P2RX7 rs208293 A fentanyl efficacy no No significant association between this variant and 24-h postoperative fentanyl use or perioperative fentanyl use. Allele A is not associated with dose of fentanyl in people with Pain, Postoperative as compared to allele G. 25472448 1450821470
P2RX7 rs2708092 G fentanyl efficacy no No significant association between this variant and 24-h postoperative fentanyl use or perioperative fentanyl use. Allele G is not associated with dose of fentanyl in people with Pain, Postoperative as compared to allele A. 25472448 1450821457
P2RX7 rs1718125 T fentanyl efficacy no No significant association between this variant and 24-h postoperative fentanyl use or perioperative fentanyl use. Please note that alleles have been complemented to the positive strand. Allele T is not associated with dose of fentanyl in people with Pain, Postoperative as compared to allele C. 25472448 1450821451
P2RX7 rs1180012 T fentanyl efficacy no No significant association between this variant and 24-h postoperative fentanyl use or perioperative fentanyl use. Allele T is not associated with dose of fentanyl in people with Pain, Postoperative as compared to allele C. 25472448 1450821464