PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ORC5	0	CDC6	0	pull down	Ramachandran N (2004)	1
MCM5	1	ORC1	3	pull down	Ramachandran N (2004)	1
MCM3	2	DBF4	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
RPA2	0	ORC1	3	two hybrid	Kneissl M (2003)	1
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
DBF4	2	MCM2	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
SNW1	0	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	ORC2	0	two hybrid	Kneissl M (2003)	1
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
CDC5L	2	ORC1	3	pull down	Ramachandran N (2004)	1
ORC3	3	ORC6	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Vashee S (2001), Sibani S (2005), Sibani S (2005), Ramachandran N (2004)	6
ORC6	0	LRWD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DMRTA1	5	ORC5	0	two hybrid	Wang J (2011)	1
DBF4	2	ORC4	1	affinity chromatography technology	Kneissl M (2003)	1
TMEM171	1	ORC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
SNW1	0	NONO	3	affinity chromatography technology	Lleres D (2010)	1
C3AR1	1	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
ORC5	0	STAB1	9	two hybrid	Wang J (2011)	1
MCM5	1	ORC5	0	pull down	Ramachandran N (2004)	1
DBF4	2	ORC1	3	two hybrid	Kneissl M (2003)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
MCM5	1	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC5L	2	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
DBF4	2	ORC6	0	two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003)	2
ORC3	3	ORC1	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hein MY (2015)	2
MCM2	3	KRT18	2	affinity chromatography technology	Drissi R (2015)	1
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
RPA2	0	ORC4	1	two hybrid	Kneissl M (2003)	1
TRIM25	5	MCM7	5	affinity chromatography technology	Choudhury NR (2017)	1
SNW1	0	CDC5L	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang C (2003), Wan C (2015), Lleres D (2010), Lleres D (2010)	4
RPA2	0	ORC2	0	two hybrid	Kneissl M (2003)	1
MCM5	1	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
SNW1	0	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
CDC45	1	ORC6	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
RPA2	0	EGFR	5	affinity chromatography technology	Marechal A (2014)	1
ORC4	1	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004)	5
ORC5	0	TXNDC11	1	two hybrid	Wang J (2011)	1
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
NFATC1	12	LRWD1	1	affinity chromatography technology	Li X (2015)	1
CDC45	1	ORC5	0	pull down	Ramachandran N (2004)	1
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
CDC5L	2	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	ORC5	0	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
NONO	3	ORC5	0	two hybrid	Wang J (2011)	1
LRWD1	1	ORC5	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
LAMB2	5	ORC5	0	two hybrid	Wang J (2011)	1
RPA2	0	NONO	3	affinity chromatography technology	Marechal A (2014)	1
NFATC1	12	ORC2	0	affinity chromatography technology	Li X (2015)	1
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
KRT18	2	TXNDC11	1	two hybrid	Wang J (2011)	1
MCM7	5	ORC4	1	pull down	Ramachandran N (2004)	1
EGFR	5	LRWD1	1	affinity chromatography technology	Tong J (2014)	1
NFATC1	12	HIST3H3	0	affinity chromatography technology	Li X (2015)	1
EGFR	5	MCM3	2	affinity chromatography technology	Liccardi G (2014)	1
CDC7	2	MCM3	2	enzymatic study, pull down	Sato N (1997), Ramachandran N (2004)	2
KRT18	2	ORC5	0	two hybrid	Wang J (2011)	1
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
HIST4H4	1	LRWD1	1	unspecified method	Vermeulen M (2010)	1
CDC5L	2	STAB1	9	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
MCM4	3	CDC45	1	affinity chromatography technology	Tan BC (2006)	1
ORC2	0	ORC4	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010)	11
RPA2	0	MCM5	1	two hybrid	Kneissl M (2003)	1
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ORC5	0	UBQLN4	2	two hybrid	Wang J (2011)	1
DGKA	3	ORC5	0	biochemical	Havugimana PC (2012)	1
MCM4	3	ORC6	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
DPEP1	1	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
CDC6	0	ORC3	3	pull down	Ramachandran N (2004)	1
DBF4	2	ORC5	0	two hybrid	Kneissl M (2003)	1
MCM3	2	CDC45	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Mulvaney KM (2016)	3
LAMP2	0	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC6	0	MCM5	1	affinity chromatography technology	Hubbi ME (2013)	1
VIPR2	1	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
MCM5	1	MCM4	3	affinity chromatography technology, biochemical, biochemical	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015)	3
MCM2	3	HIST3H3	0	affinity chromatography technology	Drissi R (2015)	1
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
MCM5	1	ORC6	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC5	0	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
HIST3H3	0	LRWD1	1	unspecified method	Vermeulen M (2010)	1
MCM3	2	MCM5	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Chen YH (2015), Lossaint G (2013), Lossaint G (2013), Mulvaney KM (2016)	13
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
ORC4	1	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC5	0	ORC5	0	two hybrid	Kneissl M (2003)	1
CDC5L	2	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
TRIM25	5	NONO	3	affinity chromatography technology	Choudhury NR (2017)	1
ORC1	3	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
LYPD3	0	ORC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM4	3	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
HIST3H3	0	ORC3	3	unspecified method	Vermeulen M (2010)	1
RPA2	0	MCM3	2	two hybrid, biochemical	Kneissl M (2003), Havugimana PC (2012)	2
CDC7	2	DBF4	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kneissl M (2003), Kumagai H (1999), Jiang W (1999), Jiang W (1999), Jiang W (1999), Kumagai H (1999), Kumagai H (1999), Liu P (2006), Masai H (2000), Masai H (2000), Huttlin EL (2017)	11
CDC5L	2	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
APLNR	1	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO2	0	RPA2	0	two hybrid	Wang J (2011)	1
ORC2	0	DBF4	2	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003)	3
MCM4	3	ORC3	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC5	0	NIF3L1	0	two hybrid	Rolland T (2014)	1
CD70	0	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
MCM5	1	KRT18	2	affinity chromatography technology	Drissi R (2015)	1
MCM5	1	HIST3H3	0	affinity chromatography technology	Drissi R (2015)	1
LAMP2	0	MCM7	5	biochemical	Havugimana PC (2012)	1
HIST3H3	0	ORC2	0	unspecified method	Vermeulen M (2010)	1
MCM2	3	HIST4H4	1	affinity chromatography technology	Drissi R (2015)	1
HIST3H3	0	ORC5	0	unspecified method	Vermeulen M (2010)	1
CDC5L	2	MCM4	3	pull down	Ramachandran N (2004)	1
ORC4	1	ORC6	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Sibani S (2005), Ramachandran N (2004)	5
MCM5	1	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology	Kneissl M (2003), Fujita M (1997), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Lossaint G (2013)	7
LRWD1	1	ORC2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
CDC6	0	MCM3	2	affinity chromatography technology, biochemical, pull down	Fujita M (1999), Mendez J (2000), Ramachandran N (2004)	3
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
EGFR	5	ORC5	0	affinity chromatography technology	Tong J (2014)	1
HIST3H3	0	HIST4H4	1	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
MCM7	5	DBF4	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
HIST4H4	1	ORC4	1	unspecified method	Vermeulen M (2010)	1
MCM3	2	ORC4	1	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
RPA2	0	MCM4	3	two hybrid	Kneissl M (2003)	1
ORC6	0	CDC6	0	pull down	Ramachandran N (2004)	1
ORC1	3	ORC4	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Hein MY (2015)	3
CDC5L	2	NONO	3	affinity chromatography technology	Lleres D (2010)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
HIST4H4	1	ORC2	0	unspecified method	Vermeulen M (2010)	1
ORC3	3	ORC5	0	two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004)	8
SNW1	0	ORC2	0	affinity chromatography technology	Lleres D (2010)	1
TRIM25	5	ORC5	0	affinity chromatography technology	Choudhury NR (2017)	1
MCM5	1	ORC2	0	two hybrid, two hybrid, biochemical	Kneissl M (2003), Kneissl M (2003), Wan C (2015)	3
TRIM25	5	MCM4	3	affinity chromatography technology	Choudhury NR (2017)	1
CDC5L	2	KRT18	2	two hybrid	Wang J (2011)	1
ORC6	0	MCM2	3	pull down	Ramachandran N (2004)	1
RPA2	0	ORC5	0	two hybrid	Kneissl M (2003)	1
MCM7	5	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
FAM234B	0	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
ORC6	0	CDC7	2	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
CDC45	1	ORC3	3	pull down	Ramachandran N (2004)	1
TRIM25	5	TXNDC11	1	affinity chromatography technology	Choudhury NR (2017)	1
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
ORC3	3	ORC4	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Dhar SK (2001), Pinto S (1999), Vashee S (2001), Sibani S (2005), Ramachandran N (2004)	5
ORC5	0	CDC7	2	pull down	Ramachandran N (2004)	1
NFATC1	12	ORC5	0	affinity chromatography technology	Li X (2015)	1
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	MCM7	5	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kukimoto I (1999), Liu P (2006)	4
CDC6	0	ORC1	3	two hybrid, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Saha P (1998), Saha P (1998), Saha P (1998), Ramachandran N (2004)	7
HIST3H3	0	ORC4	1	unspecified method	Vermeulen M (2010)	1
DBF4	2	MCM4	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
HIST4H4	1	ORC5	0	unspecified method	Vermeulen M (2010)	1
HIST3H3	0	NONO	3	unspecified method	Vermeulen M (2010)	1
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
MCM7	5	ORC3	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
RPA2	0	MCM2	3	two hybrid	Kneissl M (2003)	1
IL13RA2	0	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
LRWD1	1	ORC3	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
ORC2	0	ORC3	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015)	17
LRWD1	1	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
CALCOCO2	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Morriswood B (2007), Morriswood B (2007)	2
CDC45	1	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC5	0	TAX1BP1	3	two hybrid	Wang J (2011)	1
CALCOCO2	0	ORC5	0	two hybrid	Wang J (2011)	1
SCN2B	1	ORC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST4H4	1	ORC3	3	unspecified method	Vermeulen M (2010)	1
LRWD1	1	ORC1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CDC5L	2	MCM3	2	pull down	Ramachandran N (2004)	1
CDC6	0	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004)	5
ORC5	0	SIPA1L2	4	two hybrid	Wang J (2011)	1
LAMP2	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	MCM4	3	affinity chromatography technology	Liccardi G (2014)	1
HIST3H3	0	MCM7	5	affinity chromatography technology	Campos EI (2010)	1