PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ORC4	1	LACC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC6	3	ORC2	0	affinity chromatography technology, affinity chromatography technology	Sibani S (2005), Sibani S (2005)	2
MCM3	2	DBF4	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
RPA2	0	ORC1	3	two hybrid	Kneissl M (2003)	1
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
DBF4	2	MCM2	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
SNW1	0	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC5L	2	ORC1	3	pull down	Ramachandran N (2004)	1
DLK1	2	ORC4	1	affinity chromatography technology	Huttlin EL (2017)	1
ORC3	3	ORC6	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Vashee S (2001), Sibani S (2005), Sibani S (2005), Ramachandran N (2004)	6
ORC6	0	LRWD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDKN2A	1	ORC4	1	pull down	Ramachandran N (2004)	1
DBF4	2	ORC4	1	affinity chromatography technology	Kneissl M (2003)	1
MCM3	2	TSNAX	1	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
MCM10	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
CCL2	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
SNW1	0	XRCC6	3	affinity chromatography technology	Lleres D (2010)	1
DBF4	2	ORC1	3	two hybrid	Kneissl M (2003)	1
CD93	1	ORC4	1	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	XRCC5	5	affinity chromatography technology	Drissi R (2015)	1
ORC4	1	APP	1	pull down	Olah J (2011)	1
CAPZA2	1	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
CDC5L	2	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
DBF4	2	ORC6	0	two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003)	2
ORC3	3	ORC1	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hein MY (2015)	2
RPA2	0	ORC4	1	two hybrid	Kneissl M (2003)	1
MCM2	3	P2RX4	0	two hybrid	Wang J (2011)	1
SNW1	0	CDC5L	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang C (2003), Wan C (2015), Lleres D (2010), Lleres D (2010)	4
ORC4	1	MCM10	2	pull down	Ramachandran N (2004)	1
RPA2	0	ORC2	0	two hybrid	Kneissl M (2003)	1
KPNA1	5	ORC4	1	two hybrid	Wang J (2011)	1
MCM2	3	CAPZA2	1	affinity chromatography technology	Drissi R (2015)	1
RPA2	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shao RG (1999), Shao RG (1999), Marechal A (2014), Wan C (2015)	4
MCM10	2	APP	1	pull down, affinity chromatography technology	Olah J (2011), Huttlin EL (2017)	2
SNW1	0	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
CDKN2A	1	MCM2	3	pull down	Ramachandran N (2004)	1
MCM6	5	ORC6	0	pull down	Ramachandran N (2004)	1
ORC4	1	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004)	5
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CCL2	0	ORC2	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
CTBP1	2	ORC4	1	two hybrid	Wang J (2011)	1
CDC5L	2	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	ORC5	0	affinity chromatography technology	Lleres D (2010)	1
RPA2	0	PABPC1	5	affinity chromatography technology	Marechal A (2014)	1
MCM2	3	PABPC1	5	affinity chromatography technology	Drissi R (2015)	1
PABPC1	5	SNW1	0	biochemical	Havugimana PC (2012)	1
MLH1	6	ORC4	1	two hybrid	Wang J (2011)	1
SNW1	0	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
FBXO6	0	MCM3	2	affinity chromatography technology	Liu B (2012)	1
FBXO6	0	ORC4	1	two hybrid	Wang J (2011)	1
CDKN2A	1	CCND1	1	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Sugimoto M (1999), Ruas M (2007), Hein MY (2015), Fei HJ (2017)	4
LRWD1	1	ORC5	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC4	1	pull down	Ramachandran N (2004)	1
CDKN2A	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ORC4	1	RRM2B	1	two hybrid	Rolland T (2014)	1
ORC4	1	XRCC6	3	affinity chromatography technology	Sibani S (2005)	1
MTMR3	8	ORC4	1	affinity chromatography technology	Li X (2016)	1
MCM2	3	XRCC6	3	affinity chromatography technology	Drissi R (2015)	1
CCL2	0	MCM3	2	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
MLH1	6	CAPZA2	1	affinity chromatography technology	Hein MY (2015)	1
TSNAX	1	KLC3	3	two hybrid	Rolland T (2014)	1
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
ORC4	1	TCF4	26	two hybrid	Rolland T (2014)	1
HIST4H4	1	LRWD1	1	unspecified method	Vermeulen M (2010)	1
KLC3	3	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
CCL2	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
SNW1	0	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
XRCC5	5	ORC3	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Sibani S (2005), Sibani S (2005), Sibani S (2005)	3
ORC2	0	ORC4	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010)	11
TEAD2	2	ORC2	0	affinity chromatography technology	Li X (2015)	1
FBXL8	0	ORC4	1	two hybrid	Wang J (2011)	1
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
MCM4	3	ORC6	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
TEAD2	2	ORC4	1	affinity chromatography technology	Li X (2015)	1
CCND1	1	MCM10	2	pull down	Ramachandran N (2004)	1
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
XRCC6	3	ORC6	0	affinity chromatography technology, affinity chromatography technology	Sibani S (2005), Sibani S (2005)	2
CDC5L	2	MCM10	2	pull down	Ramachandran N (2004)	1
DBF4	2	ORC5	0	two hybrid	Kneissl M (2003)	1
TXNDC15	2	ORC4	1	affinity chromatography technology	Huttlin EL (2017)	1
P2RX4	0	ORC4	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
MCM2	3	HIST3H3	0	affinity chromatography technology	Drissi R (2015)	1
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
ORC6	0	APP	1	pull down	Olah J (2011)	1
ORC5	0	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
HIST3H3	0	LRWD1	1	unspecified method	Vermeulen M (2010)	1
FBXL5	3	ORC4	1	two hybrid	Wang J (2011)	1
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
ORC4	1	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
FBXO6	0	HIST4H4	1	affinity chromatography technology	Liu B (2012)	1
CDC5L	2	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
CCND1	1	MCM3	2	affinity chromatography technology, biochemical	Gladden AB (2003), Gladden AB (2003)	2
MCM3	2	MCM6	5	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
MCM2	3	KPNA1	5	affinity chromatography technology	Drissi R (2015)	1
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
MCM2	3	MCM10	2	pull down	Ramachandran N (2004)	1
MCM4	3	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
HIST3H3	0	ORC3	3	unspecified method	Vermeulen M (2010)	1
TEAD2	2	ORC3	3	affinity chromatography technology	Li X (2015)	1
RPA2	0	MCM3	2	two hybrid, biochemical	Kneissl M (2003), Havugimana PC (2012)	2
DBF4	2	MCM6	5	enzymatic study	Masai H (2000)	1
CDC5L	2	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
MCM10	2	MCM7	5	biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Izumi M (2000), Ramachandran N (2004), Huttlin EL (2015), Huttlin EL (2017)	4
CTBP1	2	TCF4	26	two hybrid, two hybrid	Ravasi T (2010), Corominas R (2014)	2
CCND1	1	MCM6	5	affinity chromatography technology	Gladden AB (2003)	1
CCND1	1	MCM7	5	two hybrid, pull down, affinity chromatography technology, biochemical	Gladden AB (2003), Gladden AB (2003), Gladden AB (2003), Gladden AB (2003)	4
MCM6	5	MCM10	2	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ramachandran N (2004), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
ORC2	0	DBF4	2	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003)	3
SNW1	0	MLH1	6	affinity chromatography technology	Lleres D (2010)	1
MCM4	3	ORC3	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
TEAD2	2	LRWD1	1	affinity chromatography technology	Li X (2015)	1
MCM2	3	RRM2B	1	affinity chromatography technology	Drissi R (2015)	1
MCM7	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
HIST3H3	0	ORC2	0	unspecified method	Vermeulen M (2010)	1
MCM2	3	HIST4H4	1	affinity chromatography technology	Drissi R (2015)	1
HIST3H3	0	ORC5	0	unspecified method	Vermeulen M (2010)	1
MCM2	3	APP	1	pull down	Olah J (2011)	1
CDC5L	2	MCM4	3	pull down	Ramachandran N (2004)	1
FOXL1	0	ORC4	1	affinity chromatography technology	Li X (2015)	1
FBXO25	1	ORC4	1	two hybrid	Wang J (2011)	1
ORC4	1	ORC6	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Sibani S (2005), Ramachandran N (2004)	5
CCL2	0	ORC4	1	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
SNW1	0	KPNA1	5	affinity chromatography technology	Lleres D (2010)	1
XRCC6	3	ORC3	3	affinity chromatography technology, affinity chromatography technology	Sibani S (2005), Sibani S (2005)	2
FBXO6	0	LAMP1	0	affinity chromatography technology	Liu B (2012)	1
LRWD1	1	ORC2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
TSNAX	1	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CCND1	1	ORC4	1	pull down	Ramachandran N (2004)	1
FBXO25	1	MCM7	5	affinity chromatography technology	Teixeira FR (2010)	1
HIST3H3	0	HIST4H4	1	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
MCM10	2	MCM4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM7	5	DBF4	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
HIST4H4	1	ORC4	1	unspecified method	Vermeulen M (2010)	1
MCM6	5	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CTBP1	2	HIST3H3	0	enzymatic study	Shi Y (2003)	1
MCM3	2	ORC4	1	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
XRCC5	5	ORC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matheos D (2002), Sibani S (2005), Sibani S (2005)	3
RPA2	0	MCM4	3	two hybrid	Kneissl M (2003)	1
FBXO25	1	MCM3	2	affinity chromatography technology	Teixeira FR (2010)	1
ORC1	3	ORC4	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Hein MY (2015)	3
TCF4	26	KLC3	3	two hybrid	Rolland T (2014)	1
CDC5L	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
HIST4H4	1	ORC2	0	unspecified method	Vermeulen M (2010)	1
ORC3	3	ORC5	0	two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004)	8
SNW1	0	ORC2	0	affinity chromatography technology	Lleres D (2010)	1
CCND1	1	MCM2	3	affinity chromatography technology	Gladden AB (2003)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
ORC3	3	APP	1	pull down	Olah J (2011)	1
ORC6	0	MCM2	3	pull down	Ramachandran N (2004)	1
RPA2	0	ORC5	0	two hybrid	Kneissl M (2003)	1
FBXO6	0	TXNDC15	2	affinity chromatography technology	Liu B (2012)	1
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
MTUS1	6	ORC4	1	two hybrid	Wang J (2011)	1
PABPC1	5	ORC4	1	biochemical	Wan C (2015)	1
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
MCM3	2	MCM10	2	pull down	Ramachandran N (2004)	1
ORC3	3	ORC4	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Dhar SK (2001), Pinto S (1999), Vashee S (2001), Sibani S (2005), Ramachandran N (2004)	5
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC4	1	XRCC5	5	affinity chromatography technology, imaging technique	Sibani S (2005), Sibani S (2005)	2
HIST3H3	0	ORC4	1	unspecified method	Vermeulen M (2010)	1
DBF4	2	MCM4	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
HIST4H4	1	ORC5	0	unspecified method	Vermeulen M (2010)	1
MCM10	2	ORC3	3	pull down	Ramachandran N (2004)	1
LACC1	0	TSNAX	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
IL1R2	2	ORC4	1	affinity chromatography technology	Huttlin EL (2017)	1
RPA2	0	APP	1	pull down	Olah J (2011)	1
MCM7	5	ORC3	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
RPA2	0	MCM2	3	two hybrid	Kneissl M (2003)	1
FOXL1	0	ORC2	0	affinity chromatography technology	Li X (2015)	1
LRWD1	1	ORC3	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
ORC2	0	ORC3	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015)	17
LRWD1	1	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
FOXL1	0	ORC3	3	affinity chromatography technology	Li X (2015)	1
FBXO6	0	MCM7	5	affinity chromatography technology	Liu B (2012)	1
LAMP1	0	ORC4	1	affinity chromatography technology	Huttlin EL (2017)	1
HIST4H4	1	ORC3	3	unspecified method	Vermeulen M (2010)	1
RPA2	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
LRWD1	1	ORC1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
ORC2	0	MCM10	2	two hybrid, affinity chromatography technology, pull down	Izumi M (2000), Izumi M (2000), Ramachandran N (2004)	3
FBXO6	0	PABPC1	5	affinity chromatography technology	Liu B (2012)	1
CDC5L	2	MCM3	2	pull down	Ramachandran N (2004)	1
XRCC5	5	ORC6	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Sibani S (2005), Sibani S (2005), Sibani S (2005)	3
XRCC5	5	ORC1	3	affinity chromatography technology	Matheos D (2002)	1
HIST3H3	0	MCM7	5	affinity chromatography technology	Campos EI (2010)	1
CDKN2A	1	MCM6	5	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3