PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ORC5	0	CDC6	0	pull down	Ramachandran N (2004)	1
MCM5	1	ORC1	3	pull down	Ramachandran N (2004)	1
CDK2	0	CDC7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin L (2007), Martin L (2007), Martin L (2007), Masai H (2000)	4
RPA2	0	ORC1	3	two hybrid	Kneissl M (2003)	1
DBF4	2	MCM2	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	ORC2	0	two hybrid	Kneissl M (2003)	1
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
CDC5L	2	ORC1	3	pull down	Ramachandran N (2004)	1
CDT1	2	ORC2	0	pull down	Ramachandran N (2004)	1
CDC7	2	MCM6	5	enzymatic study	Masai H (2000)	1
KAT7	3	CDC6	0	enzymatic study	Iizuka M (2006)	1
ORC1	3	MRPS15	0	affinity chromatography technology	Hein MY (2015)	1
DBF4	2	ORC4	1	affinity chromatography technology	Kneissl M (2003)	1
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
CDT1	2	CDC5L	2	pull down	Ramachandran N (2004)	1
MCM5	1	ORC5	0	pull down	Ramachandran N (2004)	1
ORC1	3	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
TERF2	2	MCM7	5	affinity chromatography technology	Giannone RJ (2010)	1
DBF4	2	ORC1	3	two hybrid	Kneissl M (2003)	1
MCM2	3	XRCC5	5	affinity chromatography technology	Drissi R (2015)	1
ORC1	3	POLE3	0	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	DIMT1	0	affinity chromatography technology	Hein MY (2015)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
CDT1	2	CCNA2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teer JK (2008), Sugimoto N (2004), Sugimoto N (2004), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
MCM5	1	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC5L	2	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
ORC1	3	MRM3	0	affinity chromatography technology	Hein MY (2015)	1
ORC3	3	ORC1	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hein MY (2015)	2
MCM2	3	ELOB	1	affinity chromatography technology	Drissi R (2015)	1
CDT1	2	CDC6	0	pull down, pull down, imaging technique	Sugimoto N (2008), Ramachandran N (2004), Sugimoto N (2015)	3
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
RPA2	0	ORC4	1	two hybrid	Kneissl M (2003)	1
RPA2	0	ORC2	0	two hybrid	Kneissl M (2003)	1
ORC1	3	PHF3	8	affinity chromatography technology	Hein MY (2015)	1
MCM5	1	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
TERF2	2	ORC3	3	pull down	Tatsumi Y (2008)	1
ORC4	1	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004)	5
TERF2	2	ORC1	3	pull down, affinity chromatography technology	Tatsumi Y (2008), Tatsumi Y (2008)	2
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC6	0	CDK2	0	affinity chromatography technology, enzymatic study	Saha P (1998), Jiang W (1999)	2
ORC1	3	CDIPT	0	affinity chromatography technology	Hein MY (2015)	1
CDC45	1	ORC5	0	pull down	Ramachandran N (2004)	1
KAT7	3	ORC2	0	enzymatic study	Iizuka M (2006)	1
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
CDC5L	2	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
CDT1	2	MCM4	3	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
MCM5	1	MCM6	5	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015), Drissi R (2015)	4
CDT1	2	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Li X (2003), Li X (2003), Sugimoto N (2008), Liu E (2004), Liu E (2004), Sugimoto N (2004), Takeda DY (2005), Hein MY (2015)	9
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
LRWD1	1	ORC5	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
SKP2	2	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Bashir T (2010), Rosner M (2009), Rosner M (2004), Zhang H (1995), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
MGMT	1	CDK2	0	affinity chromatography technology	Niture SK (2005)	1
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC4	1	pull down	Ramachandran N (2004)	1
ORC1	3	ZNF174	2	affinity chromatography technology	Hein MY (2015)	1
CDC45	1	CDK2	0	affinity chromatography technology, affinity chromatography technology	Alexandrow MG (2005), Alexandrow MG (2005)	2
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
XRCC5	5	ORC3	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Sibani S (2005), Sibani S (2005), Sibani S (2005)	3
ORC1	3	TRIM26	1	affinity chromatography technology	Hein MY (2015)	1
MCM4	3	CDC45	1	affinity chromatography technology	Tan BC (2006)	1
ORC2	0	ORC4	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010)	11
RPA2	0	MCM5	1	two hybrid	Kneissl M (2003)	1
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
RPA2	0	RFC3	0	affinity chromatography technology	Marechal A (2014)	1
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
KAT7	3	CDT1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Miotto B (2008), Miotto B (2008), Miotto B (2008), Wong PG (2010), Wong PG (2010)	5
CDC5L	2	SRP72	5	biochemical, affinity chromatography technology	Wan C (2015), Lleres D (2010)	2
KAT7	3	MCM2	3	enzymatic study	Iizuka M (2006)	1
ORC1	3	SRP72	5	affinity chromatography technology	Hein MY (2015)	1
CDC6	0	ORC3	3	pull down	Ramachandran N (2004)	1
DBF4	2	ORC5	0	two hybrid	Kneissl M (2003)	1
CDC6	0	MCM5	1	affinity chromatography technology	Hubbi ME (2013)	1
MCM5	1	MCM4	3	affinity chromatography technology, biochemical, biochemical	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015)	3
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
ORC5	0	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
ORC4	1	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC1	3	PHIP	20	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
RPA2	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
ORC1	3	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
ORC1	3	MRPL11	0	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	ELOB	1	affinity chromatography technology	Hein MY (2015)	1
MCM4	3	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
DBF4	2	MCM6	5	enzymatic study	Masai H (2000)	1
RPA2	0	SCAMP3	0	affinity chromatography technology	Marechal A (2014)	1
MGMT	1	MCM2	3	affinity chromatography technology	Niture SK (2005)	1
CDC7	2	DBF4	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kneissl M (2003), Kumagai H (1999), Jiang W (1999), Jiang W (1999), Jiang W (1999), Kumagai H (1999), Kumagai H (1999), Liu P (2006), Masai H (2000), Masai H (2000), Huttlin EL (2017)	11
KAT7	3	ORC1	3	affinity chromatography technology, pull down, two hybrid	Iizuka M (1999), Iizuka M (1999), Iizuka M (1999)	3
CDC5L	2	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
SKP2	2	ORC1	3	pull down, affinity chromatography technology	Mendez J (2002), Mendez J (2002)	2
ORC2	0	DBF4	2	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003)	3
CDT1	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liu E (2004), Sugimoto N (2004), Sugimoto N (2004), Takeda DY (2005), Varjosalo M (2013), Hein MY (2015)	6
CDC5L	2	RFC3	0	affinity chromatography technology	Lleres D (2010)	1
MCM4	3	ORC3	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDT1	2	MCM2	3	pull down	Chandrasekaran S (2011)	1
ORC1	3	PHF6	1	affinity chromatography technology	Hein MY (2015)	1
CDC45	1	MCM6	5	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
GOLGA2	2	ORC1	3	two hybrid	Rolland T (2014)	1
CDC5L	2	MCM4	3	pull down	Ramachandran N (2004)	1
MCM5	1	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology	Kneissl M (2003), Fujita M (1997), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Lossaint G (2013)	7
XRCC5	5	POLE3	0	affinity chromatography technology	Lan L (2010)	1
LRWD1	1	ORC2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	CDC5L	2	enzymatic study	Boudrez A (2000)	1
MCM7	5	DBF4	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
ORC1	3	RFC3	0	affinity chromatography technology	Hein MY (2015)	1
MCM6	5	ORC4	1	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
ORC2	0	CCNA2	1	affinity chromatography technology	Mendez J (2002)	1
MCM2	3	SRP72	5	affinity chromatography technology	Drissi R (2015)	1
XRCC5	5	ORC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matheos D (2002), Sibani S (2005), Sibani S (2005)	3
RPA2	0	MCM4	3	two hybrid	Kneissl M (2003)	1
ORC1	3	ORC4	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Hein MY (2015)	3
ORC1	3	CIRBP	1	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
ORC3	3	ORC5	0	two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004)	8
CDT1	2	ORC1	3	pull down	Ramachandran N (2004)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
MCM5	1	ORC2	0	two hybrid, two hybrid, biochemical	Kneissl M (2003), Kneissl M (2003), Wan C (2015)	3
ORC1	3	LARP7	3	affinity chromatography technology	Hein MY (2015)	1
RPA2	0	ORC5	0	two hybrid	Kneissl M (2003)	1
MCM7	5	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
ORC1	3	EXOSC2	2	affinity chromatography technology	Hein MY (2015)	1
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
CDC45	1	ORC3	3	pull down	Ramachandran N (2004)	1
ORC3	3	ORC4	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Dhar SK (2001), Pinto S (1999), Vashee S (2001), Sibani S (2005), Ramachandran N (2004)	5
ORC5	0	CDC7	2	pull down	Ramachandran N (2004)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	MCM7	5	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kukimoto I (1999), Liu P (2006)	4
ORC4	1	XRCC5	5	affinity chromatography technology, imaging technique	Sibani S (2005), Sibani S (2005)	2
CDT1	2	MCM6	5	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Sugimoto N (2008), Teer JK (2008), Liu C (2011), Hein MY (2015)	4
CDC6	0	ORC1	3	two hybrid, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Saha P (1998), Saha P (1998), Saha P (1998), Ramachandran N (2004)	7
TERF2	2	LARP7	3	affinity chromatography technology	Giannone RJ (2010)	1
DBF4	2	MCM4	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
TERF2	2	ORC2	0	pull down, affinity chromatography technology	Tatsumi Y (2008), Tatsumi Y (2008)	2
MCM7	5	ORC3	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
RPA2	0	MCM2	3	two hybrid	Kneissl M (2003)	1
GOLGA2	2	MCM7	5	two hybrid	Rolland T (2014)	1
ORC1	3	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mendez J (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
LRWD1	1	ORC3	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
ORC2	0	ORC3	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015)	17
LRWD1	1	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
MGMT	1	ORC1	3	affinity chromatography technology	Niture SK (2005)	1
ORC1	3	HARS2	0	affinity chromatography technology	Hein MY (2015)	1
CDC45	1	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	XRCC5	5	affinity chromatography technology	Neganova I (2011)	1
CDC6	0	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Petersen BO (1999), Petersen BO (1999), Saha P (1998), Jiang W (1999)	4
ORC1	3	SCAMP3	0	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
RPA2	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
ORC1	3	ZNF768	2	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
LRWD1	1	ORC1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CDK2	0	GOLGA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015)	4
CDK2	0	DBF4	2	enzymatic study	Masai H (2000)	1
TERF2	2	XRCC5	5	affinity chromatography technology, affinity chromatography technology	OConnor MS (2004), Giannone RJ (2010)	2
MCM7	5	CDT1	2	imaging technique	Sugimoto N (2015)	1
CDC6	0	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004)	5
XRCC5	5	ORC1	3	affinity chromatography technology	Matheos D (2002)	1