PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNK2	7	NTRK2	10	affinity chromatography technology, affinity chromatography technology	La Torre A (2013), La Torre A (2013)	2
SHC1	0	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
SHC3	1	NTRK2	10	affinity chromatography technology, two hybrid	Nakamura T (1998), Suzuki S (2002)	2
NTF4	0	NTRK2	10	pull down, x-ray crystallography, imaging technique	Naylor RL (2002), Banfield MJ (2001), Chen TC (2014)	3
PLCG1	6	NTRK2	10	pull down, two hybrid	Meakin SO (1999), Suzuki S (2002)	2
FRS2	0	NTRK2	10	pull down	Meakin SO (1999)	1
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
NMNAT1	0	NTRK2	10	two hybrid	Wang J (2011)	1
SHC1	0	AP1B1	6	affinity chromatography technology	Huttlin EL (2017)	1
NCK2	2	TNK2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	SH2B1	7	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
BDNF	0	NTRK2	10	pull down, pull down, pull down	Haniu M (1997), Naylor RL (2002), Aravamudan B (2012)	3
SQSTM1	0	PIK3R1	6	far western blotting, affinity chromatography technology	Sung CK (1998), Sung CK (1998)	2
SHC1	0	NTRK2	10	pull down	Meakin SO (1999)	1
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
NTRK2	10	NCK2	2	two hybrid, pull down	Suzuki S (2002), Suzuki S (2002)	2
EGFR	5	TNK2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Lin Q (2010), Pao-Chun L (2009), Shen F (2007), Howlin J (2008), Howlin J (2008), Tong J (2008), Jones S (2014), Jones S (2014), Chua BT (2010)	9
AP1B1	6	NTRK2	10	two hybrid	Wang J (2011)	1
NTRK2	10	SH2B1	7	two hybrid	Suzuki S (2002)	1
RANBP9	5	NTRK2	10	affinity chromatography technology, affinity chromatography technology	Yin YX (2010), Yin YX (2010)	2
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
BDNF	0	NTF4	0	imaging technique	Chen TC (2014)	1
PTPN1	2	NTRK2	10	unspecified method	Espanel X (2002)	1
NTRK2	10	TRAF6	0	affinity chromatography technology	Jadhav T (2008)	1
FYN	1	TNK2	7	affinity chromatography technology, pull down	Linseman DA (2001), Linseman DA (2001)	2
NTRK2	10	POLR2G	0	two hybrid	Wang J (2011)	1
TNK2	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahajan NP (2005), Mahajan NP (2005), Taipale M (2012), Gao B (2013), Mahendrarajah N (2017), Mahendrarajah N (2017), Mahendrarajah N (2017)	7
EGFR	5	AP1B1	6	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013)	2
NTRK2	10	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Geetha T (2003), Jadhav T (2008)	2
FYN	1	PIK3R1	6	pull down	Kapeller R (1994)	1
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
TRAF6	0	FYN	1	pull down	Liu A (2012)	1
HSP90AA1	7	NTRK2	10	affinity chromatography technology	Taipale M (2012)	1
NTRK2	10	GIPC1	1	affinity chromatography technology	Lou X (2001)	1
TRAF6	0	RANBP9	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Wang L (2011), Wang L (2011), Wang L (2011), Wang L (2011), Wang L (2011), Zhang J (2014)	6
TNK2	7	SQSTM1	0	affinity chromatography technology, imaging technique	Jones S (2014), Jones S (2014)	2
SHC3	1	EGFR	5	affinity chromatography technology, unspecified method, pull down	Nakamura T (1998), Jones RB (2006), OBryan JP (1996)	3
EGFR	5	NTRK2	10	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
NTRK2	10	PIK3R1	6	two hybrid	Suzuki S (2002)	1
NTF3	2	NTRK2	10	pull down	Ryden M (1996)	1
FYN	1	NTRK2	10	pull down, affinity chromatography technology	Iwasaki Y (1998), Iwasaki Y (1998)	2