PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHC1	0	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
NGF	0	NTRK1	1	pull down, pull down, x-ray crystallography, x-ray crystallography	Nykjaer A (2004), Lee R (2001), Wiesmann C (1999), Banfield MJ (2001)	4
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
NTRK1	1	PTPRR	3	affinity chromatography technology, two hybrid	Emdal KB (2015), Yao Z (2017)	2
CDC37	0	SQSTM1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Li J (2013)	2
CBL	7	HSPA4	3	affinity chromatography technology	Valiya Veettil M (2011)	1
ABL1	9	PLCG1	6	pull down	Koch A (2000)	1
CBL	7	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, far western blotting, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Soubeyran P (2003), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Miyoshi-Akiyama T (2001), Patel H (2006), Johnson KJ (2009), Shishido T (2000), Shishido T (2000), Shishido T (2000), Gaston I (2004), Jain SK (1997), Reedquist KA (1996), Bhat A (1997), Bhat A (1997), Bhat A (1997), Grossmann AH (2004), Brehme M (2009), Brehme M (2009), Brehme M (2009), Nishihara T (2003), Tsukahara F (2010)	21
ARHGAP32	11	SHC3	1	affinity chromatography technology, pull down	Nakamura T (2002), Nakamura T (2002)	2
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
FRS2	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ong SH (1996), Wong A (2002), Meakin SO (1999), Kouhara H (1997), Mason JM (2004), Liu BA (2012), Lao DH (2006), Bisson N (2011), Zhou L (2015)	9
SNX27	5	NTRK1	1	affinity chromatography technology, affinity chromatography technology	Ghai R (2013), Emdal KB (2015)	2
FRS2	0	NTRK1	1	pull down, two hybrid	Meakin SO (1999), Meakin SO (1999)	2
TNK2	7	NTRK1	1	affinity chromatography technology, affinity chromatography technology	La Torre A (2013), La Torre A (2013)	2
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
SH2B1	7	SH2B2	1	two hybrid, affinity chromatography technology	Nishi M (2005), Nishi M (2005)	2
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
NTRK1	1	PLCG1	6	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Ohmichi M (1991), Qian X (1998), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	6
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
NTRK1	1	NTRK1	1	x-ray crystallography, affinity chromatography technology, enzymatic study	Ultsch MH (1999), Emdal KB (2015), Smith BD (2015)	3
SH2B1	7	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Kotani K (1998)	2
NTRK1	1	SHC1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Borrello MG (1994), Nakamura T (2002), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	7
NEDD4	2	ABL1	9	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SHC1	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Puil L (1994), Brehme M (2009), Brehme M (2009), Brehme M (2009)	5
NTRK1	1	SH2B1	7	two hybrid, affinity chromatography technology, two hybrid	Qian X (1998), Qian X (1998), Koch A (2000)	3
SHC3	1	NTRK1	1	affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Emdal KB (2015)	2
TNK2	7	NEDD4	2	affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Lin Q (2010), Lin Q (2010), Lin Q (2010), Lin Q (2010), Hitomi Y (2013)	5
ARHGAP32	11	SHC1	0	affinity chromatography technology	Nakamura T (2002)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
NEDD4	2	CBLB	3	pull down, affinity chromatography technology, affinity chromatography technology	Magnifico A (2003), Magnifico A (2003), Magnifico A (2003)	3
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
CBLB	3	SHC1	0	affinity chromatography technology	Lavagna-Sevenier C (1998)	1
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
SH2B2	1	SHC1	0	pull down	Yokouchi M (1997)	1
ARHGAP32	11	PLCG1	6	affinity chromatography technology	Moon SY (2003)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
CBLB	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ettenberg SA (1999), Lavagna-Sevenier C (1998), Lavagna-Sevenier C (1998), Elly C (1999), Bandyopadhyay S (2010), Vinayagam A (2011), Bisson N (2011), Blagoev B (2003), Rolland T (2014), Huttlin EL (2017)	10
TNK2	7	CDC37	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Mahendrarajah N (2017)	2
NTRK1	1	GAREM1	1	affinity chromatography technology, affinity chromatography technology	Emdal KB (2015), Emdal KB (2015)	2
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
NTRK1	1	TRAF6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Jadhav T (2008), Geetha T (2005), Zheng C (2015)	3
SQSTM1	0	HSPA4	3	pull down, affinity chromatography technology	Pridgeon JW (2004), Pridgeon JW (2004)	2
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
SH2B2	1	CBL	7	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wakioka T (1999), Ng C (2008), Hu J (2005), Hu J (2005), Onnockx S (2008), Yokouchi M (1999), Yokouchi M (1999)	7
TNK2	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Satoh T (1996), Kato-Stankiewicz J (2001), Bandyopadhyay S (2010), Lin Q (2010), Lin Q (2012), Yeow-Fong L (2005), Chan W (2011), Yokoyama N (2003), Huttlin EL (2017), Mahendrarajah N (2017)	10
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
TNK2	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahajan NP (2005), Mahajan NP (2005), Taipale M (2012), Gao B (2013), Mahendrarajah N (2017), Mahendrarajah N (2017), Mahendrarajah N (2017)	7
NTRK1	1	ARHGAP32	11	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Nakamura T (2002), Nakamura T (2002), Nakamura T (2002), Emdal KB (2015)	4
SHC1	0	GAREM1	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
GRB2	2	ARHGAP32	11	two hybrid	Bandyopadhyay S (2010)	1
ABL1	9	CBLB	3	affinity chromatography technology	Brehme M (2009)	1
SH2B2	1	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Yokouchi M (1997)	2
ABL1	9	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bali P (2005), Wu LX (2006)	2
GRB2	2	GAREM1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Wang J (2011), Rolland T (2014), Huttlin EL (2017)	4
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
FRS2	0	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wong A (2002), Wong A (2002), Belleudi F (2007)	3
MATK	2	NTRK1	1	affinity chromatography technology, far western blotting	Yamashita H (1999), Yamashita H (1999)	2
TRAF6	0	CBLB	3	affinity chromatography technology	Qiao G (2007)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
NTRK1	1	SH2B2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Qian X (1998), Emdal KB (2015)	3
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
HSP90AA1	7	MATK	2	affinity chromatography technology	Taipale M (2012)	1
NTRK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2
ABL1	9	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bali P (2005), Sun H (2011), Tsukahara F (2010), Taipale M (2012), Wu LX (2006)	5
TNK2	7	SQSTM1	0	affinity chromatography technology, imaging technique	Jones S (2014), Jones S (2014)	2
NTRK1	1	CBLB	3	affinity chromatography technology, affinity chromatography technology	Emdal KB (2015), Emdal KB (2015)	2
NTRK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2