PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
NRL	0	FIZ1	1	two hybrid, pull down	Mitton KP (2003), Mitton KP (2003)	2
CRX	0	NRL	0	fluorescent resonance energy transfe	von Alpen D (2015)	1
OPTN	1	NRL	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Wang C (2014), Wang C (2014), Wang C (2014)	3
MAPK1	1	NRL	0	enzymatic study	Swain P (2007)	1
NR2E3	2	CRX	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
NR2E3	2	NRL	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
EDF1	0	NRL	0	pull down	Miotto B (2006)	1
MAPK14	0	NRL	0	enzymatic study	Swain P (2007)	1