PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXW7	2	NFKB1	2	affinity chromatography technology	Fekrmandi F (2015)	1
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
MAGEA1	0	FBXW7	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Zhao J (2017), Zhao J (2017), Zhao J (2017), Zhao J (2017)	4
MAML1	5	PHF8	6	affinity chromatography technology	Yatim A (2012)	1
RUNX3	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Jin YH (2004), Jin YH (2004)	2
MAML1	5	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Wallberg AE (2002), Fryer CJ (2002), Fryer CJ (2002), Fryer CJ (2004)	4
SNAI1	1	KDM1A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin T (2010), Lin T (2010), Lin Y (2010), Lin Y (2010), Lin Y (2010), Lin Y (2010), Wu ZQ (2012), Lin Y (2010), Huttlin EL (2015), Rivero S (2015)	10
NOTCH1	25	PHF8	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012), Yatim A (2012)	3
MAML1	5	SMARCA4	19	affinity chromatography technology	Yatim A (2012)	1
RBPJ	1	CAMK4	4	affinity chromatography technology	Choi YH (2013)	1
SMARCA4	19	CTNNB1	30	affinity chromatography technology, two hybrid	Barker N (2001), Barker N (2001)	2
ZMIZ1	7	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Pinnell N (2015), Pinnell N (2015), Pinnell N (2015), Pinnell N (2015)	4
NOTCH1	25	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012), Yatim A (2012)	3
NOTCH1	25	CAMK4	4	affinity chromatography technology, affinity chromatography technology, enzymatic study	Choi YH (2013), Choi YH (2013), Choi YH (2013)	3
RUNX3	1	RBPJ	1	affinity chromatography technology, affinity chromatography technology	Gao J (2010), Gao J (2010)	2
KAT5	1	RBPJ	1	affinity chromatography technology	Kim MY (2007)	1
SNAI1	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim SO (2011), Lim SO (2010), Lim SO (2010)	3
NOTCH1	25	KDM1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012), Yatim A (2012)	3
PHF8	6	RBPJ	1	affinity chromatography technology	Yatim A (2012)	1
MAGEA1	0	SNW1	0	two hybrid, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Laduron S (2004), Laduron S (2004), Laduron S (2004), Zhao J (2017), Zhao J (2017), Zhao J (2017), Zhao J (2017)	7
KAT5	1	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2002), Legube G (2002), Wu Q (2009), Dohmesen C (2008), Dohmesen C (2008), Kim JW (2008)	6
MDM2	2	SMARCA4	19	unspecified method	Nicholson J (2014)	1
ZMIZ1	7	RBPJ	1	affinity chromatography technology, affinity chromatography technology	Pinnell N (2015), Pinnell N (2015)	2
NOTCH1	25	JAG1	7	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Shimizu K (2000), Hansson EM (2010), Kim MY (2011), Kim MY (2011)	4
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
NFKB1	2	CTNNB1	30	imaging technique, affinity chromatography technology, imaging technique	Kim JH (2005), Kim JH (2005), Chen TC (2014)	3
NOTCH1	25	RBPJ	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nam Y (2003), Aster JC (1997), Aster JC (1997), Gao J (2010), Gao J (2010), Kim MY (2007), Kim MY (2007), Popko-Scibor AE (2011), Mo JS (2007), Kim MY (2011), Kim MY (2011), Yatim A (2012), Yatim A (2012), Choi YH (2013), Jeffries S (2002), Jeffries S (2002), Jeffries S (2002), Kitagawa M (2001), Cho S (2011), Baek HJ (2015), Baek HJ (2015), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017), Tremblay CS (2009), Tremblay CS (2009)	27
DTX4	7	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, imaging technique	Chastagner P (2017), Chastagner P (2017), Chastagner P (2017)	3
MAML1	5	RBPJ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Jeffries S (2002), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	6
ZMIZ1	7	CTNNB1	30	affinity chromatography technology	Pinnell N (2015)	1
KDM1A	2	RBPJ	1	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Li X (2015)	2
SNAI1	1	EP300	36	affinity chromatography technology	Hsu DS (2014)	1
EP300	36	SNW1	0	pull down	Leong GM (2004)	1
NFKB1	2	YY1	7	two hybrid	Wang J (2011)	1
RUNX3	1	MDM2	2	affinity chromatography technology	Chi XZ (2009)	1
NOTCH1	25	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, protein complementation assay	Gupta-Rossi N (2001), Thompson BJ (2007), Thompson BJ (2007), ONeil J (2007), ONeil J (2007), Busino L (2012), Mo JS (2007), Kim MY (2011), Yatim A (2012), Yumimoto K (2013), Baek HJ (2015), Liu B (2015), Yeh CH (2016), Ahn JS (2016), Ahn JS (2016), Zhao J (2017), Zhao J (2017), Zhao J (2017), Daakour S (2016)	19
SNW1	0	RBPJ	1	pull down, affinity chromatography technology, pull down, two hybrid	Zhou S (2000), Zhou S (2000), Zhou S (2000), Zhou S (2000)	4
MDM2	2	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sui G (2004), Sui G (2004), Sui G (2004), Dolezelova P (2012)	4
PHF8	6	KDM1A	2	genetic interference	Wong AS (2016)	1
RUNX3	1	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Gao J (2010), Gao J (2010), Gao J (2010), Gao J (2010)	4
ZMIZ1	7	MAML1	5	affinity chromatography technology	Pinnell N (2015)	1
MAML1	5	NOTCH1	25	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu L (2000), Wu L (2000), Wu L (2002), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Kim MY (2011), Yatim A (2012), Yatim A (2012), Yatim A (2012), Jeffries S (2002), Kitagawa M (2001)	11
SMARCA4	19	RBPJ	1	affinity chromatography technology	Yatim A (2012)	1
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
NOTCH1	25	SNW1	0	pull down, two hybrid, affinity chromatography technology, pull down	Beatus P (2001), Beatus P (2001), Zhou S (2000), Fryer CJ (2004)	4
NFKB1	2	KAT5	1	imaging technique, affinity chromatography technology	Kim JH (2005), Kim JH (2005)	2
EP300	36	KAT5	1	affinity chromatography technology, affinity chromatography technology	Col E (2005), Col E (2005)	2
NOV	0	NFKB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EP300	36	NOTCH1	25	affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Hao L (2010), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Popko-Scibor AE (2011)	4
KAT5	1	NOTCH1	25	affinity chromatography technology, genetic interference, affinity chromatography technology	Kim MY (2007), Kim SY (2007), Kim SY (2007)	3
MAGEA1	0	NOTCH1	25	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhao J (2017), Zhao J (2017), Zhao J (2017), Zhao J (2017)	4
NFKB1	2	NOTCH1	25	affinity chromatography technology, pull down, pull down	Guan E (1996), Guan E (1996), Wang J (2001)	3
NOTCH1	25	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down	Jin YH (2009), Jin YH (2009), Jin YH (2009)	3
EP300	36	YY1	7	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2001), Lee JS (1995), Lee JS (1995), Lee JS (1995), Lee JS (1995), Kadeppagari RK (2009), Kadeppagari RK (2009), Kadeppagari RK (2009), Sankar N (2008), Sankar N (2008), Sankar N (2008), Wang CC (2007), Wang CC (2007), Galvin KM (1997)	14
NOTCH1	25	NOV	0	affinity chromatography technology, affinity chromatography technology, pull down	Sakamoto K (2002), Sakamoto K (2002), Sakamoto K (2002)	3
NOTCH1	25	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down	Yeh TS (2003), Yeh TS (2003), Yeh TS (2003)	3
MDM2	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lim SO (2011), Lim SO (2011), Pettersson S (2012), Pettersson S (2012), Pettersson S (2012)	5
KDM1A	2	EP300	36	affinity chromatography technology	Garcia-Bassets I (2007)	1
SNAI1	1	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lim SO (2011), Lim SO (2011), Lim SO (2011), Lim SO (2011)	4
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
JAG1	7	FBXW7	2	affinity chromatography technology	Kim MY (2011)	1