PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STUB1	4	NOS1	4	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Peng HM (2004), Peng HM (2004), Clapp KM (2010), Clapp KM (2012)	4
NOS1	4	DLG2	4	two hybrid	Brenman JE (1996)	1
PTPN6	0	NOS1	4	affinity chromatography technology	Lopez F (2001)	1
SNTA1	1	DMD	6	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn AH (1996), Yang B (1995), Gee SH (1998), Lyssand JS (2008), Huttlin EL (2017)	5
RASD1	0	NOS1AP	0	pull down, affinity chromatography technology, two hybrid, two hybrid	Fang M (2000), Fang M (2000), Fang M (2000), Fang M (2000)	4
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
NOS1	4	PRKD1	7	affinity chromatography technology, two hybrid, pull down, enzymatic study	Sanchez-Ruiloba L (2014), Sanchez-Ruiloba L (2014), Sanchez-Ruiloba L (2014), Sanchez-Ruiloba L (2014)	4
ZDHHC23	1	NOS1	4	affinity chromatography technology, pull down	Saitoh F (2004), Saitoh F (2004)	2
RASD1	0	NOS1	4	pull down	Fang M (2000)	1
SYN1	1	NOS1	4	pull down	Jaffrey SR (2002)	1
DMD	6	NOS1	4	imaging technique	Brenman JE (1995)	1
NOS1	4	NOS1AP	0	two hybrid, pull down, pull down, affinity chromatography technology	Jaffrey SR (1998), Jaffrey SR (1998), Jaffrey SR (1998), Jaffrey SR (1998)	4
NOS1	4	DLG4	11	affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology	Jaffrey SR (1998), Brenman JE (1996), Brenman JE (1996), Brenman JE (1996), Brenman JE (1996)	5
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
BDKRB2	0	NOS1	4	affinity chromatography technology, affinity chromatography technology	Golser R (2000), Golser R (2000)	2
NOS1	4	HSPA4	3	affinity chromatography technology	Peng HM (2004)	1
NOS1AP	0	SYN1	1	pull down, affinity chromatography technology	Jaffrey SR (2002), Jaffrey SR (2002)	2
SNTA1	1	NOS1	4	pull down	Gee SH (1998)	1