Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
NFKB1 4790 PRANLUKAST CHEMBL21333 DrugBank 12801316, 12801315
NFKB1 4790 SGN-30 CHEMBL2109256 DrugBank
NFKB1 4790 BARDOXOLONE CHEMBL1093059 TdgClinicalTrial
NFKB1 4790 BORTEZOMIB CHEMBL325041 ClearityFoundationClinicalTrial
NFKB1 4790 CUSTIRSEN CHEMBL2108309 DrugBank
NFKB1 4790 THALIDOMIDE CHEMBL468 antagonist TdgClinicalTrial, TEND, DrugBank 11752352, 15723633
NFKB1 4790 OMTRIPTOLIDE SODIUM CHEMBL2104976 TdgClinicalTrial
NFKB1 4790 TRIFLUSAL CHEMBL1332032 antagonist DrugBank 17194886, 18317243, 19465361, 15678110

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
NFKB1 rs3774959 AG flupenthixol efficacy yes as measured by change in PANSS score. Genotype AG is associated with increased response to flupenthixol in people with Schizophrenia as compared to genotype GG. 27992301 1448568106
NFKB1 rs28362491 del etanercept efficacy no Patients received etanercept for at least 3 months. Patients were classified as responders if they achieved a Psoriasis Area and Severity Index improvement of at least 75% after 12 weeks. Allele del is associated with response to etanercept in people with Psoriasis as compared to allele ATTG. 27348478 1448254963
NFKB1 rs230493 AT flupenthixol efficacy yes as measured by change in PANSS score. Genotype AT is associated with increased response to flupenthixol in people with Schizophrenia as compared to genotype TT. 27992301 1448568086
NFKB1 rs230504 CT + TT flupenthixol efficacy yes as measured by change in PANSS score. Genotypes CT + TT is associated with increased response to flupenthixol in people with Schizophrenia as compared to genotype CC. 27992301 1448568076