PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF166	0	NF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCAF1	5	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn J (2010), Belzile JP (2007), He YJ (2006), McCall CM (2008), McCall CM (2008), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Kyei GB (2015)	14
CD44	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsatas D (2002), Wakahara K (2005), Wakahara K (2005), Perez A (2013)	4
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
AMOT	6	NF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Li Y (2015), Li Y (2015), Hauri S (2013), Zhou L (2015)	5
AMOT	6	YAP1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang C (2012), Wang C (2012), Adler JJ (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013), Hauri S (2013)	9
CD44	1	EZR	8	pull down	Legg JW (2002)	1
SLC9A3R1	2	AKT1	1	affinity chromatography technology, enzymatic study	Song GJ (2015), Song GJ (2015)	2
CD44	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS1	3	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang J (2008), Zhang J (2008), Ho KC (2011), Vigneron AM (2010), Vigneron AM (2010), Huntoon CJ (2010), Hao Y (2008), Hao Y (2008), Hao Y (2008), Hao Y (2008), Matallanas D (2007), Matallanas D (2007), Oka T (2008), Oka T (2008), Oka T (2008), Yu FX (2012), Yu FX (2012), Chiyoda T (2012), Couzens AL (2013), Ho KC (2011), Salah Z (2013), Hauri S (2013), Schuchardt BJ (2014), Mei L (2017), Enzo E (2015), Si Y (2017), Guo PD (2016)	27
EZR	8	NF2	1	far western blotting, affinity chromatography technology, pull down	Groenholm M (1999), Groenholm M (1999), Tang X (2007)	3
WWC1	5	AMOTL1	3	affinity chromatography technology	Toloczko A (2017)	1
EGFR	5	EZR	8	protein complementation assay	Petschnigg J (2014)	1
NF2	1	MED28	2	two hybrid, affinity chromatography technology	Wiederhold T (2004), Wiederhold T (2004)	2
NF2	1	SPTBN1	6	pull down, affinity chromatography technology, two hybrid	Neill GW (2001), Neill GW (2001), Neill GW (2001)	3
LATS2	1	LATS1	3	affinity chromatography technology, bioid	Xiao L (2011), Couzens AL (2013)	2
WWC1	5	LATS1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao L (2011), Xiao L (2011), Wilson KE (2014), Wilson KE (2014), Wennmann DO (2014)	5
YAP1	0	NF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Enzo E (2015)	3
YAP1	0	AMOTL1	3	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Enzo E (2015)	4
CD44	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	AMOT	6	affinity chromatography technology, bioid, enzymatic study, enzymatic study, enzymatic study	Couzens AL (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013)	5
LATS1	3	AMOTL1	3	bioid	Couzens AL (2013)	1
NF2	1	TUBA1C	1	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Zhou L (2015)	2
LATS2	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YAP1	0	EGFR	5	affinity chromatography technology	Komuro A (2003)	1
RNF166	0	AMOT	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NF2	1	SDCBP	0	pull down, pull down, two hybrid	Jannatipour M (2001), Jannatipour M (2001), Jannatipour M (2001)	3
NF2	1	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology	Huang J (2008), Huang J (2008), Huang J (2008), Huang J (2008), Huang J (2008), Li W (2010), Li W (2010), Li W (2010), Mori T (2014), Mori T (2014), Mori T (2014), Zhou L (2015), Laulajainen M (2011), Laulajainen M (2011)	14
LATS2	1	AMOTL1	3	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
AMOT	6	AMOTL1	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013)	4
RNF166	0	AMOTL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AMOTL2	5	NF2	1	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Zhou L (2015)	2
NF2	1	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Guerrero PA (2015), Ivanov AA (2017)	2
NF2	1	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (2008), Huang J (2008), Huang J (2008), Li W (2010), Li W (2010), Zhou L (2015)	6
WWC1	5	NF2	1	affinity chromatography technology, affinity chromatography technology	Xiao L (2011), Xiao L (2011)	2
NF2	1	SGSM3	5	two hybrid, pull down, affinity chromatography technology, imaging technique	Lee IK (2004), Lee IK (2004), Lee IK (2004), Lee IK (2004)	4
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
NF2	1	NOP53	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Chen H (2011), Chen H (2011), Chen H (2011), Chen H (2011), Chen H (2011)	5
CUL4A	2	TUBA1C	1	affinity chromatography technology	Bennett EJ (2010)	1
LATS2	1	AMOTL2	5	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Paramasivam M (2011), Paramasivam M (2011), Couzens AL (2013), Kim M (2016), Kim M (2016)	5
AMOT	6	AMOTL2	5	affinity chromatography technology, bioid	Wells CD (2006), Couzens AL (2013)	2
NF2	1	AMOTL1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Zhou L (2015), Huttlin EL (2017)	3
RIT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology	Huang J (2008), Huang J (2008)	2
EZR	8	SLC9A3R1	2	pull down, affinity chromatography technology, biochemical	Brdickova N (2001), Reczek D (1997), Wan C (2015)	3
AKT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Tang X (2007), Tang X (2007), Tang X (2007), Tang X (2007), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Ivanov AA (2017)	9
HGS	5	NF2	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Gutmann DH (2001), Scoles DR (2000), Scoles DR (2000), Scoles DR (2000), Scoles DR (2000), Sun CX (2002), Scoles DR (2002)	7
NF2	1	LATS1	3	pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Li Y (2015), Li Y (2015), Li Y (2015), Li Y (2015), Yin F (2013), Yin F (2013), Yin F (2013), Yin F (2013)	8
SPTBN1	6	NOP53	2	two hybrid	Sevinc A (2011)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
DCAF1	5	CCNL2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Kyei GB (2015), Kyei GB (2015), Kyei GB (2015)	3
AMOTL2	5	YAP1	0	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paramasivam M (2011), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Kim M (2016), Enzo E (2015)	6
NF2	1	SCHIP1	0	pull down, affinity chromatography technology, affinity chromatography technology	Goutebroze L (2000), Goutebroze L (2000), Goutebroze L (2000)	3
CUL4A	2	LATS1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ni W (2017), Ni W (2017), Deng J (2016)	3
AMOT	6	WWC1	5	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Toloczko A (2017)	3
SLC9A3R1	2	YAP1	0	pull down, affinity chromatography technology	Mohler PJ (1999), Mohler PJ (1999)	2
NF2	1	SLC9A3R1	2	pull down, pull down	Murthy A (1998), Li Y (2015)	2
LATS2	1	YAP1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study	Ikeda M (2009), Zhang J (2008), Zhang J (2008), Vigneron AM (2010), Vigneron AM (2010), Bao Y (2009), Kawahara M (2008), Paramasivam M (2011), Aylon Y (2010), Oka T (2008), Yu FX (2012), Mo XL (2015), Rashidian J (2015), Kim M (2016), Enzo E (2015), Si Y (2017), Ivanov AA (2017), Zhu C (2018)	18
CCNL2	2	NF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NF2	1	NF2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe	Kang BS (2002), Yin F (2013), Ivanov AA (2017)	3
NF2	1	LATS2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li Y (2015), Yin F (2013), Ivanov AA (2017), Zhu C (2018)	4
WWC1	5	LATS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao L (2011), Xiao L (2011), Wennmann DO (2014)	3
CD44	1	NF2	1	affinity chromatography technology, unspecified method, fluorescent resonance energy transfe	Tang X (2007), Mori T (2014), Ivanov AA (2017)	3
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
LATS1	3	AMOT	6	bioid, enzymatic study, affinity chromatography technology	Couzens AL (2013), Adler JJ (2013), Hauri S (2013)	3
CCNB1IP1	0	NF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Groenholm M (2006), Groenholm M (2006), Groenholm M (2006)	3
CUL4A	2	NF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (2008), Huang J (2008), Li W (2010)	3