PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCF3	7	EP300	36	biochemical, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, pull down	Bradney C (2003), Bradney C (2003), Bradney C (2003), Bradney C (2003), Hyndman BD (2012), Kim JY (2004)	6
DUSP3	1	NEUROD1	0	two hybrid	Wang J (2011)	1
SMARCA4	19	NEUROD1	0	affinity chromatography technology	Seo S (2005)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
PDHX	2	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Qiu Y (2002), Qiu Y (2002), Qiu Y (2002)	3
NEUROD1	0	HAP1	1	two hybrid, affinity chromatography technology	Marcora E (2003), Marcora E (2003)	2
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
NEUROD1	0	CCND1	1	genetic interference, affinity chromatography technology	Ratineau C (2002), Ratineau C (2002)	2
NR0B2	1	NEUROD1	0	affinity chromatography technology, two hybrid, pull down	Kim JY (2004), Kim JY (2004), Kim JY (2004)	3
MAFA	0	NEUROD1	0	affinity chromatography technology, pull down	Zhao L (2005), Zhao L (2005)	2
PDHX	2	NEUROD1	0	affinity chromatography technology, affinity chromatography technology	Qiu Y (2002), Qiu Y (2002)	2
NEUROD1	0	TCF12	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTT	14	MAP3K10	2	affinity chromatography technology, affinity chromatography technology	Liu YF (2000), Liu YF (2000)	2
DPF3	2	SMARCA4	19	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizaka A (2012), Ishizaka A (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
TCF4	26	EP300	36	affinity chromatography technology	Li J (2007)	1
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
NEUROD1	0	DPF3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HAP1	1	HTT	14	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, two hybrid	Li XJ (1995), Li SH (1998), Li SH (1998), Li SH (1998), Li XJ (1995), Li XJ (1995), Li SH (1998), Goehler H (2004), Goehler H (2004)	9
EP300	36	NEUROD1	0	pull down, pull down, affinity chromatography technology, pull down	Malecki MT (1999), Qiu Y (2002), Qiu Y (2002), Kim JY (2004)	4
EP300	36	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology	Ratineau C (2002), Fu M (2005), Fu M (2005)	3
TCF12	14	EP300	36	pull down	Zhang J (2004)	1
NEUROD1	0	HTT	14	affinity chromatography technology	Marcora E (2003)	1
NEUROD1	0	TCF4	26	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEUROD1	0	MAP3K10	2	two hybrid, affinity chromatography technology, enzymatic study	Marcora E (2003), Marcora E (2003), Marcora E (2003)	3
NEUROD1	0	TCF3	7	affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2015), Kim JY (2004), Huttlin EL (2017)	3
NEUROD1	0	LACRT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2