PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT7	1	APP	1	pull down	Olah J (2011)	1
KDM1A	2	CHD3	19	affinity chromatography technology, affinity chromatography technology	Wang Y (2009), Li Q (2011)	2
TSC1	4	NEFL	1	two hybrid, affinity chromatography technology	Haddad LA (2002), Haddad LA (2002)	2
GAN	4	KIFC3	3	affinity chromatography technology	Johnson-Kerner BL (2015)	1
NEFL	1	PPP1R16B	2	two hybrid	Rolland T (2014)	1
NEFL	1	PDE4DIP	10	two hybrid	Rolland T (2014)	1
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
KIFC3	3	USP2	0	two hybrid	Rolland T (2014)	1
KRT15	2	NEFL	1	two hybrid	Rolland T (2014)	1
NEFL	1	NME7	0	two hybrid	Rolland T (2014)	1
AR	3	NEFL	1	bioid	Lempiaeinen JK (2017)	1
NEFM	0	NEFL	1	affinity chromatography technology	Huttlin EL (2017)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
YWHAG	5	TERF1	1	two hybrid, two hybrid	Bandyopadhyay S (2010), Lee OH (2011)	2
C16orf70	4	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
FAM83H	6	SEC16A	7	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
PPP1CC	2	NEFL	1	affinity chromatography technology	Cid C (2007)	1
SIRT7	1	SEC16A	7	affinity chromatography technology	Tsai YC (2012)	1
TERF1	1	NEFL	1	two hybrid	Lee OH (2011)	1
NEFL	1	BICD2	0	affinity chromatography technology	Huttlin EL (2017)	1
SIRT7	1	SPTAN1	9	affinity chromatography technology	Tsai YC (2012)	1
C16orf70	4	APP	1	pull down	Olah J (2011)	1
HOXB5	0	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
KIFC3	3	NEFL	1	two hybrid	Rolland T (2014)	1
PSG9	1	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
KRT15	2	PPP1R18	2	two hybrid	Rolland T (2014)	1
SIRT7	1	KDM1A	2	affinity chromatography technology	Tsai YC (2012)	1
NEFL	1	MAP2	7	pull down, pull down	Frappier T (1991), Frappier T (1991)	2
PSG9	1	NEFM	0	affinity chromatography technology	Huttlin EL (2015)	1
PPP1R16B	2	PPP1CC	2	affinity chromatography technology	Huttlin EL (2017)	1
PDE4DIP	10	KDM1A	2	two hybrid	Weimann M (2013)	1
TSC1	4	KDM1A	2	two hybrid	Weimann M (2013)	1
NEFL	1	TEX11	0	two hybrid	Rolland T (2014)	1
NEFL	1	SEC16A	7	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	CHD3	19	affinity chromatography technology	Hanson D (2014)	1
NEFL	1	BRD7	2	two hybrid	Goehler H (2004)	1
OBSL1	9	KDM1A	2	affinity chromatography technology	Hanson D (2014)	1
TSC1	4	PRMT6	2	two hybrid	Weimann M (2013)	1
PPP1CC	2	ENKD1	3	two hybrid	Fardilha M (2011)	1
KIFC3	3	KDM1A	2	two hybrid	Weimann M (2013)	1
PPP1CC	2	PPP1R18	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Esteves SL (2012), Fardilha M (2011), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	5
CHD3	19	NEFL	1	two hybrid	Goehler H (2004)	1
SYNC	0	GAN	4	affinity chromatography technology	Huttlin EL (2017)	1
NEFL	1	DPP9	4	affinity chromatography technology	Huttlin EL (2017)	1
GAN	4	NEFL	1	affinity chromatography technology	Johnson-Kerner BL (2015)	1
KRT15	2	PKN1	4	two hybrid	Rolland T (2014)	1
NEFL	1	PRMT6	2	two hybrid	Weimann M (2013)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
NEFH	4	NEFL	1	biochemical, affinity chromatography technology	Athlan ES (1997), Huttlin EL (2017)	2
RSPRY1	0	NEFL	1	affinity chromatography technology	Huttlin EL (2017)	1
YWHAG	5	RABEP1	4	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
YWHAG	5	NEFL	1	affinity chromatography technology	Jin J (2004)	1
NEFL	1	ENKD1	3	two hybrid	Rolland T (2014)	1
CDC14A	4	NEFL	1	bioid	St-Denis N (2016)	1
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NEFL	1	WDR98	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	NEFM	0	affinity chromatography technology	Zanon A (2013)	1
NEFL	1	USP2	0	two hybrid	Rolland T (2014)	1
CRYAB	0	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
NDN	0	NEFL	1	two hybrid	Corominas R (2014)	1
PDE4DIP	10	PIAS4	5	two hybrid	Wang J (2011)	1
CCDC8	1	YWHAG	5	affinity chromatography technology	Hanson D (2014)	1
GAN	4	VIM	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Johnson-Kerner BL (2015), Johnson-Kerner BL (2015), Huttlin EL (2017)	4
VIM	0	NEFM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
KIFC3	3	APP	1	pull down	Olah J (2011)	1
SKAP1	0	APP	1	pull down	Olah J (2011)	1
NEFL	1	VIM	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Goehler H (2004), Huttlin EL (2017), Boldt K (2016)	3
VIM	0	PIAS4	5	two hybrid	Goehler H (2004)	1
TERF1	1	SEC16A	7	affinity chromatography technology	Giannone RJ (2010)	1
SYNC	0	RABEP1	4	affinity chromatography technology	Huttlin EL (2017)	1
C16orf70	4	NEFH	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VIM	0	TXLNB	0	two hybrid	Rolland T (2014)	1
PKN1	4	VIM	0	two hybrid, enzymatic study, two hybrid	Matsuzawa K (1997), Matsuzawa K (1997), Rolland T (2014)	3
MAP2	7	APP	1	pull down	Olah J (2011)	1
PRKN	1	CRYAB	0	affinity chromatography technology	Gong Y (2014)	1
VIM	0	SPTAN1	9	affinity chromatography technology, affinity chromatography technology	Brown MJ (2001), Brown MJ (2001)	2
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
VIM	0	SYNC	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
TERF1	1	KDM1A	2	two hybrid	Weimann M (2013)	1
OBSL1	9	NEFL	1	affinity chromatography technology	Hanson D (2014)	1
NEFH	4	NEFM	0	affinity chromatography technology	Huttlin EL (2017)	1
NEFL	1	BICD1	2	affinity chromatography technology	Huttlin EL (2017)	1
GAN	4	NEFH	4	affinity chromatography technology	Johnson-Kerner BL (2015)	1
SYNC	0	NEFM	0	affinity chromatography technology	Huttlin EL (2017)	1
TERF1	1	SPTAN1	9	affinity chromatography technology	Giannone RJ (2010)	1
RSPRY1	0	NEFM	0	affinity chromatography technology	Huttlin EL (2017)	1
NEFL	1	APP	1	imaging technique	Chen TC (2014)	1
GAN	4	NEFM	0	affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Huttlin EL (2017)	2
YWHAG	5	TSC1	4	affinity chromatography technology	Jin J (2004)	1
CCDC8	1	NEFL	1	affinity chromatography technology	Hanson D (2014)	1
MRPL4	1	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
PRKN	1	VIM	0	affinity chromatography technology	Zanon A (2013)	1
KRT15	2	TXLNB	0	two hybrid	Rolland T (2014)	1
NEFL	1	KDM1A	2	two hybrid	Weimann M (2013)	1
SKAP1	0	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
NEFH	4	PKN1	4	pull down, two hybrid	Mukai H (1996), Mukai H (1996)	2
AR	3	KDM1A	2	affinity chromatography technology, bioid	Choi H (2016), Lempiaeinen JK (2017)	2
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
KRT15	2	USP2	0	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
PKN1	4	NEFL	1	two hybrid, pull down	Mukai H (1996), Mukai H (1996)	2
SPTAN1	9	NEFL	1	pull down	Frappier T (1987)	1
CHD3	19	PIAS4	5	two hybrid	Goehler H (2004)	1
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
NEFL	1	FAM83H	6	affinity chromatography technology	Huttlin EL (2017)	1
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
CCDC8	1	FAM83H	6	affinity chromatography technology	Hanson D (2014)	1
SIRT7	1	NEFL	1	affinity chromatography technology	Tsai YC (2012)	1
SIRT7	1	PPP1CC	2	affinity chromatography technology	Tsai YC (2012)	1
NEFL	1	RABEP1	4	affinity chromatography technology	Huttlin EL (2017)	1
PDE4DIP	10	PPP1R18	2	two hybrid	Rolland T (2014)	1
SYNC	0	NEFL	1	affinity chromatography technology	Huttlin EL (2017)	1
MRPL4	1	FAM83H	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GAN	4	SPTAN1	9	affinity chromatography technology	Johnson-Kerner BL (2015)	1
SIRT7	1	NEFM	0	affinity chromatography technology	Tsai YC (2012)	1
CCDC8	1	SEC16A	7	affinity chromatography technology	Hanson D (2014)	1
NEFL	1	PIAS4	5	two hybrid	Goehler H (2004)	1
PRKN	1	NEFL	1	affinity chromatography technology	Zanon A (2013)	1
VIM	0	RSPRY1	0	affinity chromatography technology	Huttlin EL (2017)	1
NEFL	1	TXLNB	0	two hybrid	Rolland T (2014)	1
YWHAG	5	VIM	0	affinity chromatography technology	Jin J (2004)	1
TEX11	0	PPP1R18	2	two hybrid	Rolland T (2014)	1
CCNC	0	KRT15	2	two hybrid	Rolland T (2014)	1
CRYAB	0	APP	1	pull down, pull down, unspecified method, x-ray crystallography, pull down	Raman B (2005), Narayanan S (2006), Shammas SL (2011), Mainz A (2015), Narayan P (2012)	5
ENKD1	3	APP	1	pull down	Olah J (2011)	1
APP	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1
NEFL	1	PPP1R18	2	two hybrid	Rolland T (2014)	1
VIM	0	APP	1	pull down	Olah J (2011)	1
CCNC	0	NEFL	1	two hybrid	Rolland T (2014)	1