PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBFOX2	5	PRRC2A	10	affinity chromatography technology	Huttlin EL (2015)	1
ATN1	2	KAT6A	19	two hybrid	Lim J (2006)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
EHMT2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011)	2
RERE	9	EFEMP2	0	two hybrid	Lim J (2006)	1
TRIM25	5	EFEMP1	1	affinity chromatography technology	Choudhury NR (2017)	1
RERE	9	PRRC2B	9	two hybrid	Lim J (2006)	1
RERE	9	KRTAP4-12	2	two hybrid	Lim J (2006)	1
PLSCR1	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
RERE	9	KAT6A	19	two hybrid	Lim J (2006)	1
RERE	9	NR2E1	0	pull down	Wang L (2006)	1
HNRNPL	3	RBFOX2	5	affinity chromatography technology	Fei T (2017)	1
RERE	9	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Wang L (2006), Bantscheff M (2011)	2
KAT6A	19	WDR5	2	affinity chromatography technology	Paggetti J (2010)	1
ATN1	2	PRRC2A	10	two hybrid	Lim J (2006)	1
ATN1	2	EFEMP2	0	two hybrid	Lim J (2006)	1
WDR5	2	RERE	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RERE	9	PRRC2A	10	two hybrid	Lim J (2006)	1
PSMA3	1	WDR5	2	affinity chromatography technology	Fedorova OA (2011)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RERE	9	EFEMP1	1	two hybrid	Lim J (2006)	1
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
RERE	9	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2006), Joshi P (2013), Shen Y (2007), Hein MY (2015), Huttlin EL (2017)	5
ATN1	2	EFEMP1	1	two hybrid	Lim J (2006)	1
HNRNPL	3	KAT6A	19	affinity chromatography technology	Fei T (2017)	1
EP300	36	HIST2H3C	0	enzymatic study	Cereseto A (2005)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
EP300	36	PLSCR1	0	two hybrid	Wang J (2011)	1
ATN1	2	ALG13	9	two hybrid	Lim J (2006)	1
AUTS2	10	ATN1	2	affinity chromatography technology	Gao Z (2014)	1
ZMYND8	5	HDAC2	1	affinity chromatography technology	Hein MY (2015)	1
RERE	9	EP300	36	affinity chromatography technology	Shen Y (2007)	1
NR2E1	0	HDAC1	4	affinity chromatography technology	Yokoyama A (2008)	1
HDAC1	4	ZMYND8	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Hein MY (2015)	3
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
PSMA3	1	RBFOX2	5	two hybrid	Rolland T (2014)	1
KAT6A	19	EP300	36	affinity chromatography technology	Rokudai S (2009)	1
RERE	9	ATN1	2	pull down, pull down, two hybrid, two hybrid	Yanagisawa H (2000), Yanagisawa H (2000), Lim J (2006), Lim J (2006)	4
RERE	9	TRIM22	2	two hybrid	Lim J (2006)	1
HIST2H3C	0	KAT6A	19	pull down	Paggetti J (2010)	1
ELAVL1	0	KAT6A	19	affinity chromatography technology	Abdelmohsen K (2009)	1
ATN1	2	NR2E1	0	pull down	Wang L (2006)	1
TRIM25	5	PSMA3	1	affinity chromatography technology	Choudhury NR (2017)	1
RERE	9	LZTR1	16	two hybrid	Ravasi T (2010)	1
EHMT2	4	HIST2H3C	0	enzymatic study, enzymatic study, enzymatic study	Yu Y (2012), Islam K (2011), Nishio H (2004)	3
AUTS2	10	EP300	36	affinity chromatography technology, pull down	Gao Z (2014), Gao Z (2014)	2
HNRNPL	3	RERE	9	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	CBFA2T2	3	affinity chromatography technology	Fei T (2017)	1
FBXW7	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
PSMA3	1	HDAC2	1	affinity chromatography technology	Fedorova OA (2011)	1
TRIM25	5	RBFOX2	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
ATN1	2	WDR5	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC1	4	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Xu Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
RERE	9	ECM1	1	two hybrid	Lim J (2006)	1
EHMT2	4	PRRC2B	9	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
TRIM25	5	RERE	9	affinity chromatography technology	Choudhury NR (2017)	1
AUTS2	10	WDR5	2	affinity chromatography technology	Gao Z (2014)	1
RERE	9	ZMYND8	5	two hybrid	Lim J (2006)	1
HDAC1	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
FBXW7	2	RERE	9	genetic interference	Bailey ML (2015)	1
ATN1	2	ZMYND8	5	two hybrid	Lim J (2006)	1
WDR5	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
ELAVL1	0	RERE	9	affinity chromatography technology	Abdelmohsen K (2009)	1
AUTS2	10	RERE	9	affinity chromatography technology	Gao Z (2014)	1
RERE	9	HIST2H3C	0	enzymatic study	Wang L (2008)	1
RERE	9	CBFA2T2	3	two hybrid	Lim J (2006)	1
RERE	9	RBFOX2	5	two hybrid	Lim J (2006)	1
PRRC2A	10	PSMA3	1	two hybrid	Lehner B (2004)	1
TRIM25	5	ATN1	2	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NR2E1	0	HDAC2	1	affinity chromatography technology	Yokoyama A (2008)	1
ATN1	2	PSMA3	1	two hybrid	Lim J (2006)	1
RERE	9	PLSCR1	0	two hybrid	Lim J (2006)	1
ATN1	2	RBFOX2	5	two hybrid	Lim J (2006)	1
EP300	36	WDR5	2	affinity chromatography technology	Tang Z (2013)	1
RERE	9	ALG13	9	two hybrid	Lim J (2006)	1
ATN1	2	PLSCR1	0	two hybrid	Lim J (2006)	1
EHMT2	4	WDR5	2	affinity chromatography technology	Hauri S (2016)	1
ELAVL1	0	RBFOX2	5	affinity chromatography technology, two hybrid, two hybrid	Abdelmohsen K (2009), Hegele A (2012), Hegele A (2012)	3
ATN1	2	ECM1	1	two hybrid	Lim J (2006)	1
HNRNPL	3	AUTS2	10	affinity chromatography technology	Fei T (2017)	1
ATN1	2	PRRC2B	9	two hybrid	Lim J (2006)	1
CDO1	2	RERE	9	affinity chromatography technology	Huttlin EL (2017)	1
ATN1	2	KRTAP4-12	2	two hybrid	Lim J (2006)	1
RERE	9	EHMT2	4	affinity chromatography technology, pull down	Wang L (2008), Wang L (2008)	2
ATN1	2	CBFA2T2	3	two hybrid	Lim J (2006)	1
RERE	9	PSMA3	1	two hybrid	Lim J (2006)	1