PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
PRKAB2	0	NEB	21	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	MAPK1	1	affinity chromatography technology	Drissi R (2015)	1
HIPK1	1	NEB	21	affinity chromatography technology	Varjosalo M (2013)	1
TMOD4	0	NEB	21	pull down	McElhinny AS (2001)	1
SP1	0	DES	1	affinity chromatography technology	Chuang JY (2012)	1
MAPK1	1	NEB	21	biochemical	Havugimana PC (2012)	1
MCM2	3	MYPN	7	affinity chromatography technology	Drissi R (2015)	1
NEB	21	TPM1	0	pull down	Marttila M (2014)	1
TRIM63	0	NEB	21	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
MCM2	3	CALM1	0	affinity chromatography technology	Drissi R (2015)	1
ACTG2	0	NEB	21	pull down	Marttila M (2014)	1
FBXL13	1	NEB	21	affinity chromatography technology	Fung E (2018)	1
NEB	21	KLHL40	4	affinity chromatography technology, two hybrid	Garg A (2014), Garg A (2014)	2
MAPK1	1	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
CALM1	0	NEB	21	pull down	Shen X (2005)	1
APC	5	NEB	21	two hybrid	Bandyopadhyay S (2010)	1
MCM2	3	ACTG2	0	affinity chromatography technology	Drissi R (2015)	1
NEB	21	DES	1	two hybrid	Bang ML (2001)	1
SP1	0	TPM2	2	affinity chromatography technology	Chuang JY (2012)	1
TPM1	0	TPM2	2	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Brown HR (1985), Brown HR (1985), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	5
MAPK14	0	NEB	21	affinity chromatography technology	Varjosalo M (2013)	1
NEB	21	TPM2	2	pull down	Marttila M (2014)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
MCM2	3	NEB	21	affinity chromatography technology	Drissi R (2015)	1
MAPK14	0	SP1	0	affinity chromatography technology	Pan W (2008)	1
CALM1	0	MAPK14	0	affinity chromatography technology	Kim J (2016)	1
STK3	1	NEB	21	affinity chromatography technology	Varjosalo M (2013)	1
TRIM55	2	NEB	21	two hybrid	Witt CC (2008)	1
TRIM55	2	DES	1	two hybrid	Witt CC (2008)	1
TRIM63	0	DES	1	two hybrid	Witt CC (2008)	1
XIRP2	11	NEB	21	two hybrid, pull down	Eulitz S (2013), Eulitz S (2013)	2
NEB	21	MYPN	7	two hybrid, pull down, pull down	Bang ML (2001), Bang ML (2001), Ma K (2002)	3
SP1	0	TPM1	0	affinity chromatography technology	Chuang JY (2012)	1
SP1	0	CALM1	0	affinity chromatography technology	Chuang JY (2012)	1
XIRP1	9	NEB	21	two hybrid, pull down	Eulitz S (2013), Eulitz S (2013)	2
NEB	21	TMOD1	1	pull down	McElhinny AS (2001)	1
SNTA1	1	NEB	21	affinity chromatography technology	Lyssand JS (2008)	1
SP1	0	NEB	21	affinity chromatography technology	Chuang JY (2012)	1